A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

Mikolaichuk, O. V.; Popova, E.; Protas, A. V.; Rakipov, Ilnaz T.; Nerukh, Dmitry; Petrov, Andrey V.; Чарыков, Н. А.; Ageev, Sergei V.; Tochilnikov, Grigorii V.; Zmitrichenko, Iulia G.; Стуков, А. Н.; Semenov, Konstantin N.; Sharoyko, Vladimir V.

doi:10.1016/j.molliq.2022.119043

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Cited by 8 publications

(1 citation statement)

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“…In our group, the investigation of the physicochemical properties (density, viscosity, refraction index, solubility, partition coefficient, etc) as well as the stability of substance 1 solutions at various pH were carried out [33]. Special attention was paid to the study of its biocompatibility and bioactivity.…”

Section: Introductionmentioning

confidence: 99%

Covalent conjugates based on nanodiamonds with doxorubicin and a cytostatic drug from the group of 1,3,5-triazines: Synthesis, biocompatibility and biological activity

Sharoyko,

Berdichevsky,

Vasina

et al. 2023

Biochimica et Biophysica Acta (BBA) - General Subjects

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Section: Introductionmentioning

confidence: 99%

Covalent conjugates based on nanodiamonds with doxorubicin and a cytostatic drug from the group of 1,3,5-triazines: Synthesis, biocompatibility and biological activity

Sharoyko,

Berdichevsky,

Vasina

et al. 2023

Biochimica et Biophysica Acta (BBA) - General Subjects

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Aziridine‐Functionalized 1,3,5‐Triazine Derivatives as Promising Anticancer Agents: Synthesis, DFT Study, DNA Binding Investigations and In Vitro Cytotoxic Activity

Protas,

Mikolaichuk,

Popova

et al. 2024

Journal of Heterocyclic Chem

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Herein, we report a synthesis and characterization of aziridine‐functionalized 1,3,5‐triazine derivatives. Electronic structure and the most preferable geometry of substances were calculated by DFT method. DNA binding investigations were conducted as part of the biomedicinal research as well as the cytotoxic activity of these compounds was evaluated using in vitro assays toward Huh‐7 and A549 cancer cell lines and HEK‐293 normal cell line. The results demonstrate that some of the synthesized compounds exhibit potent cytotoxic activity ([5‐[[4,6‐bis(aziridin‐1‐yl)‐1,3,5‐triazin‐2‐yl]amino]‐2,2‐dimethyl‐1,3‐dioxan‐5‐yl]methanol (1) and 4,6‐di(aziridine‐1‐yl)‐N‐(2,2,5‐trimethyl‐1,3‐dioxane‐5‐yl)‐1,3,5‐triazine‐2‐amine (9)), making them potential candidates for further development as anticancer agents.

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Study of biocompatibility, cytotoxic activity in vitro of a tetrazole-containing derivative of 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine

Mikolaichuk

Popova²,

Protas³

et al. 2022

Biochemical and Biophysical Research Communications

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A cytostatic drug from the class of triazine derivatives: Its properties in aqueous solutions, cytotoxicity, and therapeutic activity

Cited by 8 publications

References 55 publications

Covalent conjugates based on nanodiamonds with doxorubicin and a cytostatic drug from the group of 1,3,5-triazines: Synthesis, biocompatibility and biological activity

Covalent conjugates based on nanodiamonds with doxorubicin and a cytostatic drug from the group of 1,3,5-triazines: Synthesis, biocompatibility and biological activity

Aziridine‐Functionalized 1,3,5‐Triazine Derivatives as Promising Anticancer Agents: Synthesis, DFT Study, DNA Binding Investigations and In Vitro Cytotoxic Activity

Study of biocompatibility, cytotoxic activity in vitro of a tetrazole-containing derivative of 2-amino-4,6-di(aziridin-1-yl)-1,3,5-triazine

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