Biocompatibility and Anti-Bacterial Activity of Zn-Containing HA/TiO2 Hybrid Coatings on Ti Substrate

Zhang, Jingying

doi:10.2485/jhtb.22.311

Cited by 16 publications

(14 citation statements)

References 18 publications

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“…In accordance with the existing literature, the most common elements used for hydroxyapatite doping are silver and zinc. It is known that silver is used in HAp doping for its antimicrobial properties, while the zinc content can lead also to increased biocompatible properties of the coating, and may contribute to the wound healing process [17,[55][56][57][58][59].…”

Section: Discussionmentioning

confidence: 99%

“…Furthermore, Thian et al [32], in their studies on "zinc-substituted hydroxyapatite: a biomaterial with enhanced bioactivity and antimicrobial properties", demonstrated that the presence of Zn 2+ ions in the structure of the hydroxyapatite stimulated the bioactivity of HAp. On the other hand, previous research [32,[55][56][57][58][59] provides information on the antimicrobial activity of ZnHAp against various pathogens. Radovanović et al [33] showed that E. coli, S. aureus, P. aeruginosa, and C. albicans were susceptible to Zn-HA, and the degree of reduction was increased when the zinc ion content increased.…”

Section: Discussionmentioning

confidence: 99%

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Zinc Doped Hydroxyapatite Thin Films Prepared by Sol–Gel Spin Coating Procedure

et al. 2019

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In this study, ZnHAp layers deposited on a Si substrate were obtained by a sol–gel spin-coating procedure. The ZnHAp solutions used to obtain the ZnHAp coatings were investigated by dynamic light scattering (DLS) analysis, ζ-potential, ultrasound measurements, and flame atomic absorption spectrometry (AAS). The average measured hydrodynamic diameter from the DLS analysis, ζ-potential, and ultrasound measurements were analyzed so as to characterize and estimate the stability of the ZnHAp nanoparticles. The AAS results confirmed the presence of zinc in the gels used in the preparation of the ZnHAp layers. The layers were investigated by X-ray diffraction (XRD) and scanning electron microscopy (SEM). The XRD results revealed the diffraction peaks of the hexagonal hydroxyapatite in all of the investigated samples. The morphology of the ZnHAp coatings annealed at 500 °C (ZnHAp-500) and 700 °C (ZnHAp-700), which evidenced that no fissures or cracks formed on the surface of the coatings. The biocompatibility assays indicated that the ZnHAp coatings did not present any toxicity towards the HeLa cells. Furthermore, the study regarding the cytotoxicity of the ZnHAp layers against microorganisms emphasized that ZnHAp coatings exhibited an inhibitory effect towards S. aureus bacterial cells and also towards C. albicans fungal cells.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Zinc Doped Hydroxyapatite Thin Films Prepared by Sol–Gel Spin Coating Procedure

et al. 2019

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“…Zinc (Zn 2+ ) ion substitution in biomaterials has been thoroughly investigated, for both its osteogenic [95] and antibacterial activities [96][97][98][99][100][101][102][103][104]. The mechanism of inhibition of microbial growth by zinc ions includes several aspects.…”

Section: Zinc-substituted Hydroxyapatitementioning

confidence: 99%

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Szurkowska¹,

Laskus²,

Kolmas³

2018

Hydroxyapatite - Advances in Composite Nanomaterials, Biomedical Applications and Its Technological Facets

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Hydroxyapatite materials, due to their high biocompatibility, play a crucial role in orthopaedics and bone surgery as alternatives to autologous bone grafts. It was also found that coatings of metallic implants with hydroxyapatite layer improve significantly their osseointegration. Due to its bioactivity, osteoconductivity and non-toxicity, hydroxyapatite is also widely used as a component of hybrid biomaterials. The implantation of "foreign" materials brings one major concern that is the risk of potential bone tissue infections or chronic osteomyelitis. In turn, the main problem concerning bacterial infection treatment is to obtain an adequate, bactericidal drug concentration maintained for a sufficient period of time in the bone tissue. Therefore, recent developments of materials engineering are focused on delivery antibiotics directly into the affected bone. To achieve this goal, hydroxyapatite-based materials are frequently studied as carriers for antibacterial drugs. For effective support of antibiotic therapy, the antibacterial activity of certain ions (including silver, zinc or copper) may be applied. In our work, we present recent developments on ceramic materials for bacterial bone infections: hydroxyapatite-based carriers for antibiotics and modifications of hydroxyapatite with antibacterial ions. In this review, state-of-the-art and current applications of such materials are presented and discussed. We want to also present our recent results.

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“…Superior bioactivity and hydrophilicity on the implants' surface are important qualities, which can enhance rapid osseointegration [4] . Scholars have investigated many surface modification methods, including Ti plasma coating, hydroxyapatite coating, micro-arc oxidation, and plasma spraying [5,6,7] . Each method has its advantages and disadvantages according to its materials and processes.…”

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confidence: 99%

Surface Property and Biocompatibility of Ti and Ti6Al4V for Dental Implants

Zhang¹

2014

Proceedings of the 2014 International Conference on Mechatronics, Electronic, Industrial and Control Engineering

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The aim of this study was to investigate the surface propertity and biocompatibility of Ti and Ti6Al4V after the treatments of sandblasting by Al 2 O 3 and etching by hydrochloric acid-sulfuric acid mixture. Surface morphology of samples was observed using scanning electron microscopy and the roughness and three-dimensional structures were detected by 3D laser scanning confocal microscope. Simulated body fluid (SBF) tests were conducted to compare the biocompatibility of the samples. The size of the contact angle was measured by a microscope using a measuring instrument. After sandblasting and acid etching, the surfaces of Ti and Ti6Al4V presented micron-size porous morphology and were hydrophilic. Even though microstructures of the alloys exhibited somewhat similar, the deposition of calcium (Ca) and phosphate (P) on the surface of Ti6Al4V alloy was greater and faster than that of Ti, which is significant for dental implants. Sprague-Dawley rats were seeded on the surfaces of Ti and Ti6Al4V and their adhesion observed using Calcein-AM staining. Surface modification of Sandblasting and acid etching promoted bioactivity of Ti and Ti6Al4V surfaces, although sandblasted and acid-etched Ti6Al4V showed better biocompatibility than Ti.

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Biocompatibility and Anti-Bacterial Activity of Zn-Containing HA/TiO2 Hybrid Coatings on Ti Substrate

Cited by 16 publications

References 18 publications

Zinc Doped Hydroxyapatite Thin Films Prepared by Sol–Gel Spin Coating Procedure

Zinc Doped Hydroxyapatite Thin Films Prepared by Sol–Gel Spin Coating Procedure

Hydroxyapatite-Based Materials for Potential Use in Bone Tissue Infections

Surface Property and Biocompatibility of Ti and Ti6Al4V for Dental Implants

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