Biocides Resistance Profiles of Biofilm Forming Bacteria of  Dairy Niche and their Control

Makwana, Mitali; Grover, Chand Ram; Kumar, Narendra

doi:10.20546/ijcmas.2018.702.147

Cited by 3 publications

(2 citation statements)

References 15 publications

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“…Disinfection with surfactants is a common practice for biofilm removal from steel and glass surfaces in food and dairy industries. While most effective surfactants include anionic, ionic and alkali compounds, other acidic compounds, phenolics, iodine, chlorine, caustic products and peracetic acid are also used to inhibit biofilm formation by altering the physio-chemical properties of surfaces [68]. Surfactants also retard growth of flagella which results in poor microbial adhesion to substratum and hindrance in biofilm formation [69].…”

Section: Strategies To Control Biofilm Growthmentioning

confidence: 99%

Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms

et al. 2018

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Biofilm is a mode of living employed by many pathogenic and environmental microbes to proliferate as multicellular aggregates on inert inanimate or biological substrates. Several microbial diseases are associated with biofilms that pose challenges in treatment with antibiotics targeting individual cells. Bacteria in biofilms secrete exopolymeric substances that contribute to architectural stability and provide a secure niche to inhabiting cells. Quorum sensing (QS) plays essential roles in biofilm development. Pathogenic bacteria in biofilms utilize QS mechanisms to activate virulence and develop antibiotic resistance. This review is a brief overview of biofilm research and provides updates on recent understandings on biofilm development, antibiotic resistance and transmission, and importance of QS mechanisms. Strategies to combat biofilm associated diseases including anti-biofilm substances, quorum quenching molecules, bio-surfactants and competitive inhibitors are briefly discussed. The review concludes with updates on recent approaches utilized for biofilm inhibition and provides perspectives for further research in the field.

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Section: Strategies To Control Biofilm Growthmentioning

confidence: 99%

Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms

et al. 2018

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“…Recent reports revealed rapid emergence of extreme drug resistance in India in sulfonamide resistant S. maltophilia and carbapenem resistance conferred by New Delhi metallo-beta-lactamase 1 (NDM-1) in Enterobacteriaceae strains (1, 14). Furthermore, studies have reported emergence of biocides (absolute ethanol, povidone iodine, sodium hypochlorite, and QACs) resistance among multidrug resistance bacteria such as: Escherichia coli, Klebsiella pneumoniae, Pseudomonas aeruginosa and Staphylococcus aureus and diverse biofilm forming bacteria of dairy niche (15, 16). Use of emerging cost-effective nanopore technologies are revolutionizing investigation of such extreme antimicrobial resistance by allowing rapid access of complete genome information.…”

Section: Introductionmentioning

confidence: 99%

Extreme genome selection towards complete antimicrobial resistance in a nosocomial strain ofStenotrophomonas maltophiliacomplex

Bansal

Patil

Kaur

et al. 2019

Preprint

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We report first complete genome sequence and analysis of an extreme drug resistance (XDR) nosocomial Stenotrophomonas maltophilia that is resistant to the mainstream drugs i.e. trimethoprim/sulfamethoxazole (TMP/SXT) and levofloxacin. Taxonogenomic analysis revealed it to be a novel genomospecies of the Stenotrophomonas maltophilia complex (Smc). Comprehensive genomic investigation revealed fourteen dynamic regions (DRs) exclusive to SM866, consisting of diverse antibiotic resistance genes, efflux pumps, heavy metal resistance, various transcriptional regulators etc. Further, resistome analysis of Smc clearly depicted SM866 to be an enriched strain, having diversified resistome consisting of sul1 and sul2 genes. Interestingly, SM866 does not have any plasmid but it harbors two diverse super-integrons of chromosomal origin. Apart from genes for sulfonamide resistance (sul1 and sul2), both of these integrons harbor an array of antibiotic resistance genes linked to ISCR (IS91-like elements common regions) elements. These integrons also harbor genes encoding resistance to commonly used disinfectants like quaternary ammonium compounds and heavy metals like mercury. Hence, isolation of a novel strain belonging to a novel sequence type (ST) and genomospecies with diverse array of resistance from a tertiary care unit of India indicates extent and nature of selection pressure driving XDRs in hospital settings. There is an urgent need to employ complete genome based investigation using emerging technologies for tracking emergence of XDR at the global level and designing strategies of sanitization and antibiotic regime.Impact StatementThe hospital settings in India have one of the highest usage of antimicrobials and heavy patient load. Our finding of a novel clinical isolate of S. maltophilia complex with two super-integrons harbouring array of antibiotic resistance genes along with antimicrobials resistance genes indicates the extent and the nature of selection pressures in action. Further, the presence of ISCR type of transposable elements on both integrons not only indicates its propensity to transfer resistome but also their chromosomal origin suggests possibilities for further genomic/phenotypic complexities. Such complex cassettes and strain are potential threat to global health care. Hence, there is an urgent need to employ cost-effective long read technologies to keep vigilance on novel and extreme antimicrobial resistance pathogens in populous countries. There is also need for surveillance for usage of antimicrobials for hygiene and linked/rapid co-evolution of extreme drug resistance in nosocomial pathogens. Our finding of the chromosomal encoding XDR will shed a light on the need of hour to understand the evolution of an opportunistic nosocomial pathogen belonging to S. maltophilia.RepositoriesComplete genome sequence of Stenotrophomonas maltophilia SM866: CP031058

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Antimicrobial Coatings for Food Contact Surfaces: Legal Framework, Mechanical Properties, and Potential Applications

Dominguez

Nguyen

Hunt

et al. 2019

Comp Rev Food Sci Food Safe

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Food contact surfaces (FCS) in food processing facilities may become contaminated with a number of unwanted microorganisms, such as Listeria monocytogenes, Escherichia coli O157:H7, and Staphylococcus aureus. To reduce contamination and the spread of disease, these surfaces may be treated with sanitizers or have active antimicrobial components adhered to them. Although significant efforts have been devoted to the development of coatings that improve the antimicrobial effectiveness of FCS, other important coating considerations, such as hardness, adhesion to a substrate, and migration of the antimicrobial substance into the food matrix, have largely been disregarded to the detriment of their translation into practical application. To address this gap, this review examines the mechanical properties of antimicrobial coatings (AMC) applied to FCS and their interplay with their antimicrobial properties within the framework of relevant regulatory constraints that would apply if these were used in real‐world applications. This review also explores the various assessment techniques for examining these properties, the effects of the deposition methods on coating properties, and the potential applications of such coatings for FCS. Overall, this review attempts to provide a holistic perspective. Evaluation of the current literature urges a compromise between antimicrobial effectiveness and mechanical stability in order to adhere to various regulatory frameworks as the next step toward improving the industrial feasibility of AMC for FCS applications.

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Biocides Resistance Profiles of Biofilm Forming Bacteria of Dairy Niche and their Control

Cited by 3 publications

References 15 publications

Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms

Biofilms: Architecture, Resistance, Quorum Sensing and Control Mechanisms

Extreme genome selection towards complete antimicrobial resistance in a nosocomial strain ofStenotrophomonas maltophiliacomplex

Antimicrobial Coatings for Food Contact Surfaces: Legal Framework, Mechanical Properties, and Potential Applications

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