Biocides in Human Follicular Fluid

Baukloh, V.; Bohnet, H. G.; Trapp, Michael; Heeschen, W.; Feichtinger, Wilfried; Kemeter, P.

doi:10.1111/j.1749-6632.1985.tb37525.x

Cited by 50 publications

(28 citation statements)

References 17 publications

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“…It was Trapp [30] who first demonstrated the presence of these chlorinated hydrocarbons in the follicular fluid of women (in a mean of 553 ng/g) and highlighted the potential threat to reproductive health posed by these contaminants. Since then several study reported the presence of PCBs in human follicular fluid in concentrations up to 1600 ng/g [31][32][33]. Furthermore, PCBs have been detected in human ovarian tissue [34], human embryos and fetuses [35].…”

Section: Introductionmentioning

confidence: 99%

Impact of endocrine disrupters on ovarian function and embryonic development

Gandolfi

Pocar²,

Brevini

et al. 2002

Domestic Animal Endocrinology

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Section: Introductionmentioning

confidence: 99%

Impact of endocrine disrupters on ovarian function and embryonic development

Gandolfi

Pocar²,

Brevini

et al. 2002

Domestic Animal Endocrinology

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“…Organochlorine pesticides are routinely detected in the body tissues and milk of animals and humans (Baukloh et al, 1985;Foster, 1995;Sonawane, 1995;Thompson and Treble, 1996) and there is controversy over their potential as endocrinedisrupting xenobiotics (Colborn et al, 1993;Turner and Sharpe, 1997). Many pesticides are lipophilic and bioaccumulate in lipid stores and tissues such as the mammary gland (Antunes-Madeira and Madeira, 1985;Kutz et al, 1991;Sitarska et al, 1995).…”

Section: Introductionmentioning

confidence: 99%

Reproductive and endocrine function in rams exposed to the organochlorine pesticides lindane and pentachlorophenol from conception

Beard

Bartlewski²,

Chandolia³

et al. 1999

Reproduction

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“…These concentrations are environmentally relevant and physiologically achievable based on pesticide levels reported for human follicular Article | Developmental injury in pesticide-exposed embryos Environmental Health Perspectives • VOLUME 112 | NUMBER 6 | May 2004 aspirates (Baukloh et al 1985;Jarrell et al 1993) and for maternal and cord blood samples collected at delivery (Waliszewski et al 2000). Comparisons between contaminant concentrations in maternal and cord plasma samples suggest a balanced state between mother and fetus with respect to circulating pesticides and metabolites (Whyatt et al 2003).…”

Section: Discussionmentioning

confidence: 99%

“…Just before ovulation, follicles become highly vascularized (Edwards et al 1980). This increased blood flow may enhance transfer and accumulation of pollutants from serum to follicular fluids (Baukloh et al 1985). Adjuvants (paraffinic oils and/or surfactant mixtures) were not included in the test formulations.…”

Section: Discussionmentioning

confidence: 99%

Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos.

Greenlee

Ellis

Berg

2004

Environ Health Perspect

148

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Occupational exposures to pesticides may increase parental risk of infertility and adverse pregnancy outcomes such as spontaneous abortion, preterm delivery, and congenital anomalies. Less is known about residential use of pesticides and the risks they pose to reproduction and development. In the present study we evaluate environmentally relevant, low-dose exposures to agrochemicals and lawn-care pesticides for their direct effects on mouse preimplantation embryo development, a period corresponding to the first 5-7 days after human conception. Agents tested were those commonly used in the upper midwestern United States, including six herbicides [atrazine, dicamba, metolachlor, 2,4-dichlorophenoxyacetic acid (2,4-D)], pendimethalin, and mecoprop), three insecticides (chlorpyrifos, terbufos, and permethrin), two fungicides (chlorothalonil and mancozeb), a desiccant (diquat), and a fertilizer (ammonium nitrate). Groups of 20-25 embryos were incubated 96 hr in vitro with either individual chemicals or mixtures of chemicals simulating exposures encountered by handling pesticides, inhaling drift, or ingesting contaminated groundwater. Incubating embryos with individual pesticides increased the percentage of apoptosis (cell death) for 11 of 13 chemicals (p ≤ 0.05) and reduced development to blastocyst and mean cell number per embryo for 3 of 13 agents (p ≤ 0.05). Mixtures simulating preemergent herbicides, postemergent herbicides, and fungicides increased the percentage of apoptosis in exposed embryos (p ≤ 0.05). Mixtures simulating groundwater contaminants, insecticide formulation, and lawn-care herbicides reduced development to blastocyst and mean cell number per embryo (p ≤ 0.05). Our data demonstrate that pesticide-induced injury can occur very early in development, with a variety of agents, and at concentrations assumed to be without adverse health consequences for humans.

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Biocides in Human Follicular Fluid

Cited by 50 publications

References 17 publications

Impact of endocrine disrupters on ovarian function and embryonic development

Impact of endocrine disrupters on ovarian function and embryonic development

Reproductive and endocrine function in rams exposed to the organochlorine pesticides lindane and pentachlorophenol from conception

Low-dose agrochemicals and lawn-care pesticides induce developmental toxicity in murine preimplantation embryos.

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