Biochip Platforms for DNA Diagnostics

Deisingh, Anil K.; Guiseppi-Wilson, Adilah; Guiseppi‐Elie, Anthony

doi:10.1007/978-0-387-72719-6_14

Cited by 6 publications

(3 citation statements)

References 41 publications

(45 reference statements)

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“…Voltammetry is a sub-class of amperometry which measures the flow of electrons as a varied potential is swept across the working electrode [ 118 , 122 ]. Tang et al devised a cost-effective electrochemical microfluidic immunoarray containing eight miniaturized ports in order to achieve 256 individual working microelectrodes, simultaneously detecting PSA alongside PSMA, IL-6 and PF-4, within one hour [ 123 ].…”

Section: Multiplexed Detection Of Pca Protein Biomarkers Via Miniaturized Biosensor Systemsmentioning

confidence: 99%

Multiplexed Prostate Cancer Companion Diagnostic Devices

Aidoo-Brown

Moschou

Estrela

2021

Sensors

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Prostate cancer (PCa) remains one of the most prominent forms of cancer for men. Since the early 1990s, Prostate-Specific Antigen (PSA) has been a commonly recognized PCa-associated protein biomarker. However, PSA testing has been shown to lack in specificity and sensitivity when needed to diagnose, monitor and/or treat PCa patients successfully. One enhancement could include the simultaneous detection of multiple PCa-associated protein biomarkers alongside PSA, also known as multiplexing. If conventional methods such as the enzyme-linked immunosorbent assay (ELISA) are used, multiplexed detection of such protein biomarkers can result in an increase in the required sample volume, in the complexity of the analytical procedures, and in adding to the cost. Using companion diagnostic devices such as biosensors, which can be portable and cost-effective with multiplexing capacities, may address these limitations. This review explores recent research for multiplexed PCa protein biomarker detection using optical and electrochemical biosensor platforms. Some of the novel and potential serum-based PCa protein biomarkers will be discussed in this review. In addition, this review discusses the importance of converting research protocols into multiplex point-of-care testing (xPOCT) devices to be used in near-patient settings, providing a more personalized approach to PCa patients’ diagnostic, surveillance and treatment management.

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Section: Multiplexed Detection Of Pca Protein Biomarkers Via Miniaturized Biosensor Systemsmentioning

confidence: 99%

Multiplexed Prostate Cancer Companion Diagnostic Devices

Aidoo-Brown

Moschou

Estrela

2021

Sensors

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“…Corporate interest centers on the potential of biochips to be used either as point-of-care diagnostics or as high-throughput screening platforms for drug lead identification. The key challenge to making this industry as universally applicable as processor chips in the computer industry is the development of a standardized chip platform that can be used with a variety of "motherboard" systems to stimulate widespread application (Deisingh, Wilson and Elie, 2009).…”

Section: Biochips Technologymentioning

confidence: 99%

Study on Biochips Technology

Oyebola¹,

Odueso

Olugbemi³

2017

SSRN Journal

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“…Bagheri et al have described the use of Ag nanoparticles/Zn-based MOF (AgNPs@Zn-MOF) to enhance the electrochemical activities of MOFs for the selective detection of patulin 5 . Substrates selected for biosensor manufacture must be relatively inert, possess a surface consistency ideal for ligand attachment 6 . There are many different types of substrates, such as glass slide, polymer, paper, etc.…”

Section: Introductionmentioning

confidence: 99%

Determination of the efficiency of AgNPs/ZIF-8 coating on different substrates

Trinh

Lai²,

Pham³

et al. 2022

Sci.Tech.Dev.J.-Eng.Tech.

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Depending on different applications or materials that integrate with the substrate as well as the transduction method used in the biosensors, different materials of the substrate are considered. This research focuses on selecting the appropriate substrate in designing biosensors, detecting microorganisms in the environment. In this study, the glass slide (glass), Polyethylen plastic (PE plastic), and the cellulose paper (cellulose acetate (CA) & cellulose nitrate (CN)) are investigated substrates for coating AgNPs/ZIF-8 – material used as an optical signal amplification in further steps, using structural analysis techniques – Scanning Electron Microscopy (SEM) for morphology characterization and the Energy Dispersive Spectrometer (EDS) for optical characterization. A morphology characterization with SEM showed that cellulose paper is a better substrate in comparing with the other substrates (glass, PE), because the sensity of distribution on CN was the highest (85-90%) when it coated with AgNPs/ZIF-8. According to EDS analysis, the ratios of Ag in mixture on CN substrate (15.38±0.39% mass) is slightly higher than CA substrate (13.58±0.39% mass); and about 53 times higher than glass substrate (0.37±0.13% mass) and PE plastic substrate (0.29±0.08%). Therefore, cellulose paper (CA) will be suggested to select for further research as a new material with cost (inexpensive) and effectiveness in coating AgNPs/ZIF-8.

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Biochip Platforms for DNA Diagnostics

Cited by 6 publications

References 41 publications

Multiplexed Prostate Cancer Companion Diagnostic Devices

Multiplexed Prostate Cancer Companion Diagnostic Devices

Study on Biochips Technology

Determination of the efficiency of AgNPs/ZIF-8 coating on different substrates

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