Biochemometric approach combined with 1D CSSF-TOCSY for the identification of sensitization agents in Curcuma longa L. and prediction of their action mechanisms

Curcuminoids as Anticancer Drugs: Pleiotropic Effects, Potential for Metabolic Reprogramming and Prospects for the Future

“…Lactate shuttle, which is needed for establishment of a synergistic metabolism between glycolytic tumor cells and tumor cells relying on OXPHOS, is highly dependent on the activity of lactate transporters MCT1 and MCT4 (SLC16A1 solute carrier family 16, members 1 and 4). In order to explore the effect of chemosensitization of the whole extract of the C. longa , and then each active compound separately: curcumin, bis-curcumin and demethoxycurcumin, with respect to cancer cell response to 5-FU and lactate metabolism, Li et al [ 142 ] used the 5-FU resistant colon cancer cell line, HCT8, previously shown to overexpress MCT1 [ 143 ]. The authors were able to show that the chemosensitizing effect of the whole extract, in this experimental model, partially relates to a significantly decreased expression of MCT1 and high increase of intracellular lactate (three- and four-fold change), after application of curcumin and bis-curcumin, respectively.…”