Biochemistry of the Protein Hormones

Renal excretion of hyaluronidase and calcium in man during the antidiuretic action of vasopressins and some analogues

“…From the observations that the synthetic analogue, leucine8-vasopressin (= oxypressin) has a low pressor activity (Katsoyannis, 1957), whereas arginine8-vasopressin has a high pressor activity, Katsoyannis & du Vigneaud (1959) concluded that, 'a strong basic aminoacid in the side chain is one requirement for high pressor activity'. As reported by Acher (1960), the most potent octapeptide in this series of analogues is arginine8-vasopressin with 600 pressor u./mg, as compared with 300 pressor u./mg for lysine8-vasopressin, 125 u./mg for arginine8oxytocin and 3 u./mg for leucine8-vasopressin. From the present results it would appear that the antidiuretic activity is even more affected by changes in the molecule, since this has been expressed throughout in relation to pressor activity.…”

Vasopressin and Oxytocin: Keys to Understanding the Neural Control of Physiology and Behaviour

“…The latter included the Mortyn Jones Memorial Lecture, which was given this year by Tatsushi Onaka from the Jichi Medical School. Finally, at the meeting banquet, Professor Roger Acher of the Laboratory of Chemical Biology, University of Paris, was honored for his pioneering work in isolating and identifying vasopressin and other neurohypophysial peptides (5). Professor Acher received a long‐lasting standing ovation.…”

Chemical Modifications of Proteins and Their Significance in Enzymology, Immunochemistry, and Related Subjects

“…located at the active center, the enzymic activity will be destroyed. After the determination of the amino acid sequence in insulin by Sanger and co-workers (23), the elucidation of the exact constitution of several peptide hormones ensued (21,22). The most frequently employed reactions, their specificity, and the results so far obtained with various proteins were adequately reviewed by several authors (1)(2)(3)(4)(5)(6)(7)(8)(9).…”

“…The most frequently employed reactions, their specificity, and the results so far obtained with various proteins were adequately reviewed by several authors (1)(2)(3)(4)(5)(6)(7)(8)(9). The syntheses of oxytocin and vasopressin by du Vigneaud and colleagues (21,22) and, more recently, of the essential part of ACTH by Hofmann and co-workers (25) opened up new possibilities for modification of these hormones through synthesis of analogues with altered amino acid sequence. Discussion of individual cases is limited to more recent findings.…”