Vasopressin and Oxytocin: Keys to Understanding the Neural Control of Physiology and Behaviour

Vries, Geert J. De; Veenema, Alexa H.; Brown, Colin H.

doi:10.1111/j.1365-2826.2012.02305.x

Cited by 8 publications

(6 citation statements)

References 5 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A similar dose response curve has been reported in several studies involving OXT and other peptides [40,65]. A better understanding of the dynamic role of the OXT system during development would be required for the interpretation of these results [39,66,67]. Further, OXT developmental effects are not limited to the OXT system and behaviour and are suggested to Fig.…”

Section: Discussionsupporting

confidence: 71%

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse

Morais

Golubeva

Casey

et al. 2021

Neuropsychopharmacol.

View full text Add to dashboard Cite

The oxytocin (OXT) system has been strongly implicated in the regulation of social behaviour and anxiety, potentially contributing to the aetiology of a wide range of neuropathologies. Birth by Caesarean-section (C-section) results in alterations in microbiota diversity in early-life, alterations in brain development and has recently been associated with long-term social and anxiety-like behaviour deficits. In this study, we assessed whether OXT intervention in the early postnatal period could reverse C-section-mediated effects on behaviour, and physiology in early life and adulthood. Following C-section or per vaginum birth, pups were administered with OXT (0.2 or 2 μg/20 μl; s.c.) or saline daily from postnatal days 1–5. We demonstrate that early postnatal OXT treatment has long-lasting effects reversing many of the effects of C-section on mouse behaviour and physiology. In early-life, high-dose OXT administration attenuated C-section-mediated maternal attachment impairments. In adulthood, low-dose OXT restored social memory deficits, some aspects of anxiety-like behaviour, and improved gastrointestinal transit. Furthermore, as a consequence of OXT intervention in early life, OXT plasma levels were increased in adulthood, and dysregulation of the immune response in C-section animals was attenuated by both doses of OXT treatment. These findings indicate that there is an early developmental window sensitive to manipulations of the OXT system that can prevent lifelong behavioural and physiological impairments associated with mode of birth.

show abstract

Section: Discussionsupporting

confidence: 71%

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse

Morais

Golubeva

Casey

et al. 2021

Neuropsychopharmacol.

View full text Add to dashboard Cite

show abstract

“…Additionally, cumulative evidence indicated a prominent role of OXT in parental and copulatory behaviors 5 – 7 and as a pro-social neuromodulator 8 , 9 increasing the salience of social stimuli and regulating social behaviors as well as aggression, anxiety, fear, and trust 10 – 20 . Conversely, AVP has been proposed to antagonize OXT-mediated functions 21 , 22 like increasing social stress 23 and reducing interpersonal trust in humans 23 – 25 . However, this view is being revisited after several studies exposed a more complex scenario for the interplay of OXT and AVP in the central nervous system (CNS) 5 , 6 , 8 , 9 , 26 .…”

Section: Introductionmentioning

confidence: 99%

Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain

Madrigal

Jurado

2021

Commun Biol

View full text Add to dashboard Cite

Oxytocin (OXT) and arginine vasopressin (AVP) support a broad range of behaviors and homeostatic functions including sex-specific and context-appropriate social behaviors. Although the alterations of these systems have been linked with social-related disorders such as autism spectrum disorder, their formation and developmental dynamics remain largely unknown. Using novel brain clearing techniques and 3D imaging, we have reconstructed the specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain with unprecedented cellular resolution. A systematic quantification indicates that OXT and AVP neurons in the hypothalamus display distinctive developmental dynamics and high cellular plasticity from embryonic to early postnatal stages. Our findings reveal new insights into the specification and consolidation of neuropeptidergic systems in the developing CNS.

show abstract

“…Also, VSP is released more in male-typical behaviour, such as pair-bond formation and competition (seen in aggressive actions) (Heinrichs and Domes, 2008;de Vries et al, 2012), as well as protective aggression (Heinrichs and Domes, 2008;Kanat et al, 2014). Maternal aggression is also correlated positively with OXT release in PVB and cAM (de Vries et al, 2012).…”

Section: Empathy Is a Temperamental Trait That Is Related More To Behavioural Orientation Than Emotionalitymentioning

confidence: 96%

“…Variations in the OXT gene indeed were linked to antisociality in adolescent boys (Hovey et al, 2016); however, this sex-age group is also known for having high testosterone, low cortisol, and dopamine (Rosenblitt et al, 2001;Sinclair et al, 2014). Also, VSP is released more in male-typical behaviour, such as pair-bond formation and competition (seen in aggressive actions) (Heinrichs and Domes, 2008;de Vries et al, 2012), as well as protective aggression (Heinrichs and Domes, 2008;Kanat et al, 2014). Maternal aggression is also correlated positively with OXT release in PVB and cAM (de Vries et al, 2012).…”

Section: Empathy Is a Temperamental Trait That Is Related More To Behavioural Orientation Than Emotionalitymentioning

confidence: 99%

Emotionality vs. Other Biobehavioural Traits: A Look at Neurochemical Biomarkers for Their Differentiation

Trofimova

Gaykalova

2021

Front. Psychol.

View full text Add to dashboard Cite

This review highlights the differential contributions of multiple neurochemical systems to temperament traits related and those that are unrelated to emotionality, even though these systems have a significant overlap. The difference in neurochemical biomarkers of these traits is analysed from the perspective of the neurochemical model, Functional Ensemble of Temperament (FET) that uses multi-marker and constructivism principles. Special attention is given to a differential contribution of hypothalamic–pituitary hormones and opioid neuropeptides implicated in both emotional and non-emotional regulation. The review highlights the role of the mu-opioid receptor system in dispositional emotional valence and the role of the kappa-opioid system in dispositional perceptual and behavioural alertness. These opioid receptor (OR) systems, microbiota and cytokines are produced in three neuroanatomically distinct complexes in the brain and the body, which all together integrate dispositional emotionality. In contrast, hormones could be seen as neurochemical biomarkers of non-emotional aspects of behavioural regulation related to the construction of behaviour in fast-changing and current situations. As examples of the role of hormones, the review summarised their contribution to temperament traits of Sensation Seeking (SS) and Empathy (EMP), which FET considers as non-emotionality traits related to behavioural orientation. SS is presented here as based on (higher) testosterone (fluctuating), adrenaline and (low) cortisol systems, and EMP, as based on (higher) oxytocin, reciprocally coupled with vasopressin and (lower) testosterone. Due to the involvement of gonadal hormones, there are sex and age differences in these traits that could be explained by evolutionary theory. There are, therefore, specific neurochemical biomarkers differentiating (OR-based) dispositional emotionality and (hormones-based) body’s regulation in fast-changing events. Here we propose to consider dispositional emotionality associated with OR systems as emotionality in a true sense, whereas to consider hormonal ensembles regulating SS and EMP as systems of behavioural orientation and not emotionality.

show abstract

Vasopressin and Oxytocin: Keys to Understanding the Neural Control of Physiology and Behaviour

Cited by 8 publications

References 5 publications

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse

Early-life oxytocin attenuates the social deficits induced by caesarean-section delivery in the mouse

Specification of oxytocinergic and vasopressinergic circuits in the developing mouse brain

Emotionality vs. Other Biobehavioural Traits: A Look at Neurochemical Biomarkers for Their Differentiation

Contact Info

Product

Resources

About