Biochemistry of the Myometrium

Hamoir, G.

doi:10.1007/978-1-4684-2271-9_12

Cited by 18 publications

(10 citation statements)

References 123 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…An important increase has also been reported during pregnancy [1][2][3][4]. In these studies the concentration of contractile proteins were obtained from the viscosity mea surement of uterine extracts whose exact protein composition was not known, since adequate analytical techniques were unavailable [5]. Several attempts have been made over the last few years to identify the diverse components of the smooth muscle contractile apparatus [for review see [5][6][7].…”

Section: Introductionmentioning

confidence: 99%

Characterization and Comparison of the Contractile Proteins from Human Gravid and Non-Gravid Myometrium

Cavaillé

Léger

1983

Gynecol Obstet Invest

View full text Add to dashboard Cite

Electrophoretic systems were used to quantify and characterize the main proteins involved in myometrium contraction, i.e., myosin, actin, and tropomyosin. Skeletin, a cytoskeletal component was also investigated. No difference in their respective concentrations could be found in 13 uteri representing various menstrual cycle stages, postmenopausal conditions, and different gestational ages. The great variability of their tissular level observed in each of the uteri does, however, reflect the heterogeneity of the muscular component of the uterine wall. Comparison of the different forms of actin in gravid and non-gravid uteri showed an increase of the γ-form in gravid uteri. However, myosins purified from gravid and non-gravid uteri were shown to have identical ATPase activity and peptide patterns following limited chymotryptic proteolysis.

show abstract

Section: Introductionmentioning

confidence: 99%

Characterization and Comparison of the Contractile Proteins from Human Gravid and Non-Gravid Myometrium

Cavaillé

Léger

1983

Gynecol Obstet Invest

View full text Add to dashboard Cite

show abstract

“…The results might indicate that energy is mainly derived from fatty acid breakdown in leiomyomas. Lipid metabo lism in human myometrium and in leiomyo mas has rarely been investigated [16]. In pregnant rhesus monkeys lipids arc consid ered to be the major energy source for resting myometrium [17].…”

Section: Discussionmentioning

confidence: 99%

Activities in Leiomyomas and Myometrium of Enzymes Involved in Energy Metabolism

Herrmann¹,

Degiampietro²,

Peheim³

et al. 1987

Gynecol Obstet Invest

View full text Add to dashboard Cite

The activities of six enzymes involved in energy metabolism were measured in leiomyoma specimens and in the adjacent normal myometrium from the uterus of 17 patients. In leiomyomas the specific activities of hexokinase, lactate dehydrogenase and hydroxyacyl-CoA dehydrogenase (HAD) were higher than in myometrium. The soluble protein content was lower in leiomyomas. Therefore, most of the differences of specific activities were not found when the enzyme activity was expressed per gram wet weight of tissue, except for HAD activity, which was still higher in leiomyomas (p < 0.05). This result is compatible with increased fatty acid utilization by leiomyomas, and with the increased growth potential of such tumors.

show abstract

“…The myometrium is under the influence of estrogen and progesterone, and it plays a role in maintenance of pregnancy and during parturition (1). Besides the well-known growth promoting effects of estrogen on the uterus, which are most likely mediated through intracellular estrogen receptors, this hormone has a profound influence on uterine motility.…”

mentioning

confidence: 99%

Calcium Channel, Ca++ mobilization, and Mechanical Reactivity of Estrogen- and Progesterone-Treated Rat Uterus

Kaburagi

Ando

1986

Japanese Journal of Pharmacology

View full text Add to dashboard Cite

show abstract

Biochemistry of the Myometrium

Cited by 18 publications

References 123 publications

Characterization and Comparison of the Contractile Proteins from Human Gravid and Non-Gravid Myometrium

Characterization and Comparison of the Contractile Proteins from Human Gravid and Non-Gravid Myometrium

Activities in Leiomyomas and Myometrium of Enzymes Involved in Energy Metabolism

Calcium Channel, Ca++ mobilization, and Mechanical Reactivity of Estrogen- and Progesterone-Treated Rat Uterus

Contact Info

Product

Resources

About