Biochemistry of Gastric Acid Secretion: H
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            ase

Sachs, George; Kaunitz, Jonathan D.; Mendlein, John; Wallmark, Björn

doi:10.1002/cphy.cp060312

Cited by 7 publications

(2 citation statements)

References 142 publications

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“…The two PPI are highly selective for the proton pump and undergo catalysed conversion into active forms within the acid‐forming space. The active inhibitors react with SH (thiol) groups of the proton pump, resulting in inhibition of acid formation 6,7 5 …”

Section: Introductionmentioning

confidence: 99%

A Comparative Study On The Activity Of Lansoprazole, Omeprazole And PD‐136450 On Acidified Ethanol‐ And Indomethacin‐Induced Gastric Lesions In The Rat

Chandranath

Bastaki

Singh

2002

Clin Exp Pharma Physio

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1. The proton pump inhibitors lansoprazole (LP) and omeprazole (OP) and the cholecystokinin (CCK)-receptor antagonist PD-136450 (PD) provide a broad spectrum of activities in their ability to inhibit gastric acid secretion and protect the stomach against ulcerogens. In the present study, we investigated the protective effects of these compounds against gastric ulcers induced by acidified ethanol (AE) and indomethacin. 2. Both AE (60% ethanol in 150 mmol/L HCl, 1 mL/rat) and indomethacin (30 mg/kg) produced gastric haemorrhagic lesions in the rat 1 and 6 h after oral administration, respectively. 3. The gastric mucosal protective effects of LP (1-20 mg/kg), OP (0.5-10 mg/kg) and PD (1-20 mg/kg), administered either orally or subcutaneously (s.c.) 30 min before the administration of AE or indomethacin, were dose dependent against both models of ulcer induction. 4. To determine whether the cytoprotective effect of LP, OP and PD (each 10 mg/kg) was mediated by endogenous prostaglandins (PG), indomethacin (10 mg/kg, s.c.) was administered 15 min before AE to inhibit prostanoids biosynthesis. Indomethacin reduced the cytoprotective effects of OP, but not LP, administered either orally or s.c. Indomethacin reduced the cytoprotective effect of PD administered orally, although the effect was much less significant than when PD was administered s.c. The results exclude the role of PG in mediating the protective effects of LP, whereas the possibility exists for PG to have a role in mediating the protective effects of OP and PD. 5. To investigate the possible involvement of endogenous nitric oxide (NO) in the cytoprotective action of LP, OP and PD, we treated rats with a selective inhibitor of NO synthesis, namely NG-nitro-L-arginine methyl ester (L-NAME; 25 mg/kg, s.c.). Administration of L-NAME 15 min prior to LP, OP or PD (each 10 mg/kg) orally or s.c. and challenge with AE or indomethacin did not significantly increase the degree of the ulcer index and L-NAME was not able to antagonize the protective effects of LP, OP and PD, thus excluding the role of NO in mediating the protective effects of these drugs. However, the effects of PD in reducing the indomethacin-induced ulcer index were less significant in the presence than the absence of L-NAME (P < 0.05 vs P < 0.001, respectively), suggesting a role for NO. 6. In conclusion, the results of the present study suggest that LP and OP are equally effective against AE- as well as indomethacin-induced gastric ulcers and were more potent than PD in protecting the stomach against ulcer formation. Lansoprazole, OP and PD bring about their cytoprotective action through the reduction of acid secretion and some other unknown mechanisms. However, OP and PD may exert their cytoprotective action through PG and NO pathways.

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Section: Introductionmentioning

confidence: 99%

A Comparative Study On The Activity Of Lansoprazole, Omeprazole And PD‐136450 On Acidified Ethanol‐ And Indomethacin‐Induced Gastric Lesions In The Rat

Chandranath

Bastaki

Singh

2002

Clin Exp Pharma Physio

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“…In addition, prostaglandins enhance mucosal blood flow and stimulate secretion of mucus and bicarbonate. [1,2,3] It is generally accepted that gastric ulcer is due to an imbalance between mucosal defense factors (bicarbonate, mucin, prostaglandins, nitric oxide, other peptides, and growth factors) and aggressive factors (acid and pepsin). Although patients with gastric ulcers have normal or even lower acid production than control subjects, ulcer rarely, if ever, occurs in the complete absence of acid.…”

Section: Introductionmentioning

confidence: 99%

Antiulcer Potential of a Standardized Extract of Red Orange Juice in the Rat

Vitali

Saija

Artico

et al. 2007

International Journal of Food Properties

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A standardized red orange extract (Red Orange Complex, ROC) has been evaluated for its potential protective effect on ethanol-and indomethacin-induced gastric lesions in rats. Oral administration of the ROC significantly prevented the development of gastric lesions in these experimental models. In addition, the effect of the ROC on the spontaneous healing of acetylsalicylic acid (ASA) ulcers in rats was examined. The spontaneous healing of gastric ulcer was significantly accelerated by repeated administration of the ROC. The histological condition of the mucosa, examined by scanning electronic microscopy (SEM), confirmed the in vivo data. The results, on the whole, indicate that the ROC possesses favourable antiulcer and cytoprotective properties in rat.This study was performed according to the international principles for laboratory animal use and care (EEC Directive of 1986; 86/609/EEC).

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