Biochemically active substances from microorganisms IV. Establishment of several in vitro anti-inflammatory probes applicable to microbial broths and the effects of non-steroidal anti-inflammatory drugs and antibiotics on them.

Staurosporine, a Potent Platelet Aggregation Inhibitor from aStreptomycesSpecies

“…Thus, the chemical structure and the mode of action of staurosporine also differed from earlier known inhibitors of microbial origin. Ninomiya et al 14 ) classified known platelet anti-aggregants, anti-inflammatories, and antibiotics based on 4 in vitro tests (collagen-induced aggregation, ADP-induced aggregation, heat-induced hemolysis, and protein denaturation). The mode of inhibition of staurosporine is similar to that of papaverine, which is an inhibitor of phosphodiesterase, but the activity of staurosporine is more potent and in our preliminary studies no .inhibitory acitivity against beef heart c-AMP phosphodiesterase was detected.…”

Comparison of the Activity of Ionophores with Other Antibacterial Agents Against Anaerobes

“…As part of a structure-activity study of the inhibition of platelet aggregation by certain polyether antibiotics (7,8), the susceptibility of several Bacteroides (gram-negative rods) strains to these antibiotics was observed. As a result, each class of ionophores (17) has now been tested, and their activity against anaerobes has been compared with other antibacterial agents, including newer ,-lactams.…”