Vasoactive Substances

Nakagawa, Akira

doi:10.1007/978-1-4612-4412-7_10

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Background On the Isolation Of Water-soluble Metabolites2

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1997

2022

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Cited by 3 publications

(2 citation statements)

References 34 publications

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“…28–30 For example, Ōmura's method for the discovery of bacterial alkaloids started by looking at water-soluble fractions first, and then at organic solvent fractions. 31,32 Also, the National Cancer Institute biodiscovery program has included screenings of water-soluble fractions for decades. 33–36…”

Section: Background On the Isolation Of Water-soluble Metabolitesmentioning

confidence: 99%

“…It seems that, in the past, the isolation of water-soluble compounds was more extensively performed than currently, possibly because during the golden age of antibiotics finding microbial antibiotics and other bioactive metabolites in hydrophilic fractions was frequent. 31,32,37–43 With new antibiotics discovery being increasingly more difficult, in particular antibiotics with new mechanisms-of-action, the emphasis on the isolation of water-soluble compounds has probably decreased.…”

Section: Background On the Isolation Of Water-soluble Metabolitesmentioning

confidence: 99%

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