Biochemically active sol-gel glasses: The trapping of enzymes

Braun, Sergei; Rappoport, S.; Zusman, Rivka; Avnir, David; Ottolenghi, Michael

doi:10.1016/j.matlet.2007.03.046

Cited by 385 publications

(53 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This study, in combination with other studies on silica xerogel physical properties such as surface area and pore volume [2,12] and on the in vivo biocompatibility and resorbability of silica xerogel [3], showed early on the major potential of using sol-gel polymerized ceramics (xerogels) as controlled release materials for the treatment of bone infection.…”

Section: Vancomycin-containing Silica Sol-gels: Synthesis and Releasementioning

confidence: 55%

See 1 more Smart Citation

Silicon oxide based materials for controlled release in orthopedic procedures

Bhattacharyya

Ducheyne

2015

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

Section: Vancomycin-containing Silica Sol-gels: Synthesis and Releasementioning

confidence: 55%

“…Shortly after, entrapment or immobilization of molecules was pursued. Since the nineties, enzymes have been entrapped in sol-gel processed materials with high retention of activity [2][3][4]. When entrapped in the sol-gel material, the enzymes were intended to function as biocatalyzers within the sol-gel matrix.…”

Section: Introductionmentioning

confidence: 99%

Silicon oxide based materials for controlled release in orthopedic procedures

Bhattacharyya

Ducheyne

2015

Advanced Drug Delivery Reviews

View full text Add to dashboard Cite

“…In this study, 30% of initial phosphatase activity was recovered after encapsulation. This activity was then retained for at least two months of storage (94). Because of their transparency, xerogels are perfectly suited for encapsulation of active agents for use as biosensor components (11,67).…”

Section: Sol-gelsmentioning

confidence: 99%

Enzyme Immobilization by Microencapsulation: Methods, Materials, and Technological Applications

Rother

Nidetzky

2014

Encyclopedia of Industrial Biotechnology

View full text Add to dashboard Cite

Microencapsulation as a major technique of enzyme immobilization is reviewed. Fabrication of enzyme‐containing microcapsules is broadly categorized according to whether a semipermeable membrane coating or a porous polymeric network structure is primarily responsible for enclosure of enzymes within the internal microcapsule phase. Microcapsules are mostly spherical with diameters usually in the micro‐ to millimeter range and exhibit core‐shell structures of variable complexity. Liposomes and vesicles formed from amphiphilic (co)‐polymers (polymersomes) are widely used to prepare membrane‐coated microcapsules. Hydrogels, sol–gels and other organic–inorganic hybrid materials, or layer‐by‐layer structures made through controlled assembly of polyelectrolytes are used to prepare microcapsules composed of internal polymeric networks. Method combination where polymeric network microcapsules are coated with a suitable membrane to generate tailored core‐shell structures is also used for enzyme encapsulation. Advances in the material sciences contribute to the development of microcapsules with improved properties such as enhanced morphological stability, reduced enzyme leakage, and designed physicochemical permeability and enzyme biocompatibility. Soluble enzymes, but also enzyme aggregates and other insoluble enzyme preparations, are encapsulated. Multienzyme microcapsules are interesting small‐scale bioreactors for confined and even compartmentalized cascade biotransformation. Techniques of microcapsule preparation are described, and applications of microencapsulated enzymes in biotechnology and biomedicine are discussed.

show abstract

“…Basecatalyzed or two-step acid-base-catalyzed sol-gels have been used for the encapsulation of enzymes, cells and living tissues [1][2][3]. Acid-catalyzed sol-gels have been studied as controlled release materials of drugs and growth factors [4][5][6][7][8][9][10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%