Biochemical studies on structural and nonstructural proteins of the African green monkey B-lymphotropic papovavirus (LPV)

Brade, Lore; Mueller‐Lantzsch, Nikolaus; Kaiser, Sonja; Scharrer, Monique

doi:10.1016/0042-6822(83)90160-5

Cited by 15 publications

(7 citation statements)

References 15 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Serological cross-reactions have been reported within the SV40 class (Pipas, 1992) of large T antigens (Takemoto et al, 1982;Brade et al, 1983). Results of immunoprecipitation experiments as described here show that there exists some antigenic relationship between PyV, as the prototype member of the PyV class (Pipas, 1992), and SV40 large T antigens, but not with BFDV early proteins.…”

Section: Discussionmentioning

confidence: 60%

Molecular and biological characteristics of avian polyomaviruses: isolates from different species of birds indicate that avian polyomaviruses form a distinct subgenus within the polyomavirus genus

Stoll

Luo

Kouwenhoven³

et al. 1993

Journal of General Virology

View full text Add to dashboard Cite

The isolation and characterization of two avian polyomaviruses, from chicken (BFDV-2) and a parrot (BFDV-3), is reported. Both isolates are closely related to the non-mammalian polyomavirus budgerigar fledgling disease virus (BFDV) isolated from budgerigars (now called BFDV-1), and all three viral genomes are shown to have the same basic size of 4981 bp. A 151 bp insertion was, however, observed in the non-coding region of BFDV-2 which represented an exact duplication of the left half of the non-coding region, including the putative early promoter and amino terminus of the large T antigen. With a further 15 base pairs exchanged elsewhere throughout the three genomes, these viruses have distinct degrees of tropism for various avian species. The production of antibodies directed against a fl-galactosidase-large T antigen fusion protein of BFDV-1 is described. These antibodies detected the large T antigen, with an M r of approximately 80K, and the small t antigen, with an M~ of approximately 24K, in cells infected with BFDV isolates. Whereas these antibodies bind with low affinity to the large T antigen of simian virus 40 (SV40), SV40-or mouse polyomavirus-specific antibodies will not bind to the BFDV large T antigen. Antibodies directed against BFDV structural polypeptides exhibit broad, reciprocal cross-reactivities with all three structural proteins of mammalian polyomaviruses. The significance of polyomavirus infections in various avian species is discussed. Based on unique structural and biological properties we propose that these viruses should be placed in a distinct subgenus (Avipolyomavirus) within the polyomaviruses.

show abstract

Section: Discussionmentioning

confidence: 60%

Molecular and biological characteristics of avian polyomaviruses: isolates from different species of birds indicate that avian polyomaviruses form a distinct subgenus within the polyomavirus genus

Stoll

Luo

Kouwenhoven³

et al. 1993

Journal of General Virology

View full text Add to dashboard Cite

show abstract

“…Antibody evidence from blood tests indicates some 15–30% of adults are infected with a still undiscovered human relative of the African green monkey virus 20. If MCV turns out to be this long‐sought agent, then more than one billion people worldwide could already be infected 21. It is obvious that the mere presence of MCV is not enough for malignant transformation.…”

Section: Discussionmentioning

confidence: 99%

Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission

Loyo¹,

Guerrero-Preston²,

Brait³

et al. 2010

Intl Journal of Cancer

159

186

View full text Add to dashboard Cite

Merkel Cell Virus (MCV) is a newly discovered polyomavirus, recently found in a rare skin cancer, Merkel cell carcinoma (MCC). However, MCV has also been detected in some normal tissue samples. We tested and compared the relative quantity of the MCV in a set of diverse human tissue samples with the MCC samples. The levels of MCV in MCCs were over 60 times higher than the highest values in all other tissues. Low quantities of MCV were detected in diverse tissue samples independently of malignant or benign histologic status. Higher levels of the virus were found in the upper aerodigestive tract, digestive system, and saliva compared to the lung and genitourinary system samples. These results confirm that MCV is widespread in the human body and suggest a possible fecal-oral transmission route similar to the Hepatitis A virus. Despite widespread presence of the virus, it appears that only neuroendocrine skin cells are susceptible to transformation by MCV.Merkel cell carcinomas (MCC) are rare neuroendocrine skin tumors that develop from neuroendocrine cells responsible for the sense of touch and pressure. The incidence of MCC has tripled over the past 20 years to about 1,500 cases a year. Increased ascertainment has at least in part contributed to this rise in incidence. People at risk include those with fair skin, excessive sunlight exposure, and a history of numerous nonmelanoma skin cancers. Additionally, patients under immunosuppression including solid organ transplant recipients, and patients with altered lymphocytic function such as patients with AIDS, lymphoma, and leukemia appear to be predisposed to MCC.

show abstract

“…This virus belongs to the Polyomaviridae family, that consists of small, non-enveloped DNA viruses. LPV shares morphologic features with the other known human polyomaviruses, BK Virus (BKV) and JC Virus (JCV), but it is antigenically distinct from them 2,3. Seroepidemiological studies revealed that human sera react in the presence of LPV antigens 4,5, and, recently, the viral genome was amplified in the peripheral blood from patients affected with HIV-related leukoencephalopathies 6.…”

Section: Introductionmentioning

confidence: 99%

Lymphotropic Polyomavirus is detected in peripheral blood from immunocompromised and healthy subjects

Delbue

Tremolada

Elia³

et al. 2010

Journal of Clinical Virology

View full text Add to dashboard Cite

Background-Lymphotropic Polyomavirus (LPV) was isolated from a B-lymphoblastoid cell line of an African green monkey. This virus shares some characteristics with human polyomaviruses, but it is antigenically distinct from BK Virus (BKV) and JC Virus (JCV). Seroepidemiological studies revealed that human sera react in the presence of LPV antigens, and, recently, the viral genome was amplified in the peripheral blood from patients affected with HIV-related leukoencephalopathies.

show abstract

Biochemical studies on structural and nonstructural proteins of the African green monkey B-lymphotropic papovavirus (LPV)

Cited by 15 publications

References 15 publications

Molecular and biological characteristics of avian polyomaviruses: isolates from different species of birds indicate that avian polyomaviruses form a distinct subgenus within the polyomavirus genus

Molecular and biological characteristics of avian polyomaviruses: isolates from different species of birds indicate that avian polyomaviruses form a distinct subgenus within the polyomavirus genus

Quantitative detection of Merkel cell virus in human tissues and possible mode of transmission

Lymphotropic Polyomavirus is detected in peripheral blood from immunocompromised and healthy subjects

Contact Info

Product

Resources

About