Biochemical Studies on Dwarfism,Hypogonadism, and Anemia

Prasad, Ananda S.; Miale, August; Farid, Z.; Sandstead, Harold H.; Schulert, Arthur R.; Darby, William J.

doi:10.1001/archinte.1963.03620280007003

Cited by 308 publications

(79 citation statements)

References 19 publications

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“…Prasad et al, 1961Prasad et al, , 1963 were the ®rst to show severe growth retardation in male subjects in the Middle East as a consequence of Zn de®ciency. Similar observations were made on workers in Turkey much earlier by Tayanc, 1942;cited in Cavdar et al, 1983 without knowing the underlying cause.…”

Section: History and Initiation Of The Nato-funded Projectmentioning

confidence: 99%

Zinc deficiency as a practical problem in plant and human nutrition in Turkey: A NATO-science for stability project

Çakmak¹,

Kalaycı²,

Ekiz³

et al. 1999

Field Crops Research

279

158

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Zinc (Zn) de®ciency is a critical nutritional problem for plants and humans in Turkey. About 14 Mha of cropped land in Turkey are known to be Zn de®cient, particularly cereal growing areas of Anatolia. In 1993, a joint research project was started in Turkey with the ®nancial support of the NATO-Science for Stability Programme to select and characterize cereal genotypes with high yield and/or high Zn accumulation in grain under de®cient supply of Zn.Field, greenhouse and growth chamber experiments were carried to study morphological, physiological and genetic factors determining the bases of genotypical differences in Zn ef®ciency among cereal species and within cultivars of wheat. Among the cereals, rye had particularly high Zn ef®ciency (high yield under Zn de®ciency). There were large genotypical differences among wheat lines. High Zn ef®ciency was closely associated with enhanced capacity of some lines to take up Zn from soils, but not with increased Zn accumulation per unit dry weight of shoot or grain. Measurement of Zn-containing superoxide dismutase activity in leaves revealed that an ef®cient utilization of Zn at the tissue or cellular level is an additional major factor involved in Zn ef®ciency of cereals.Zinc present in grains from Anatolia seems to be not bioavailable. Phytate : Zn molar ratios in grains, a widely accepted predictor of Zn bioavailability, were extremely high and ranged between 95 and 216 for crops grown severely on Zn-de®cient soils of Central Anatolia. In the studies concerning determination of Zn nutritional status of school children in Southeastern Anatolia, most children were found to be of shorter stature and had very low levels of Zn (<100 mg kg À1 ) in hair. #

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Section: History and Initiation Of The Nato-funded Projectmentioning

confidence: 99%

Zinc deficiency as a practical problem in plant and human nutrition in Turkey: A NATO-science for stability project

Çakmak¹,

Kalaycı²,

Ekiz³

et al. 1999

Field Crops Research

279

158

View full text Add to dashboard Cite

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“…While some trials have demonstrated a positive effect of iron supplementation on growth (Angeles et al, 1993;Lind et al, 2004), meta-analyses of all trials did not demonstrate a benefit (Ramakrishnan et al, 2004). Zinc is an essential micronutrient for growth and deficiency can lead to severe growth retardation (Prasad et al, 1963). Daily zinc supplementation appears to have an overall positive effect on both height and weight among all children under 5 years with a more pronounced positive effect among children who are undernourished at baseline (Brown et al, 2002).…”

Section: Introductionmentioning

confidence: 99%

Low-dose weekly supplementation of iron and/or zinc does not affect growth among Bangladeshi infants

et al. 2007

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Objectives: To determine the effect of low-dose weekly supplementation with iron, zinc or both on growth of infants from 6 to 12 months of age. Subjects/Methods: A total of 645 breastfed infants age 6 months who were not severely anemic (HbX90 g l À1 ) or severely malnourished (weight-for-age X60% median) were randomized to receive 20 mg iron and 1 mg riboflavin; 20 mg zinc and 1 mg riboflavin; 20 mg iron, 20 mg zinc and 1 mg riboflavin; or riboflavin alone (control) weekly for 6 months. Results: Baseline characteristics were similar among the four supplementation groups. Weight, length and mid-upper arm circumference were assessed at baseline, 8, 10 and 12 months of age. There was no interaction of iron and zinc when given in a combined supplement on either weight or length (P40.05). There were no effects of either iron or zinc on the rate of length or weight gain for all infants or when stratified by baseline Hb concentration. Conclusions: Weekly supplementation of 20 mg Fe, 20 mg Zn, or both does not benefit growth among infants 6-12 months of age in rural Bangladesh, a region with high rates of anemia and zinc deficiency.

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Section: Introductionmentioning

confidence: 99%

“…Human zinc deficiency was first recognized in the 1960s among adolescent boys in Iran and Egypt who showed signs of severe growth retardation and developmental delays (Prasad et al, 1963). Severe zinc deficiency, as was observed by Prasad et al (1963), is easy to recognize through dwarfism, hypogonadism and severe developmental delays. However, many consequences of zinc deficiency, including stunting and increased rates of infectious diseases such as diarrhea and pneumonia, are also shared by other nutritional and environmental factors and are thus more difficult to recognize (Caulfield and Black, 2004).…”

Section: Introductionmentioning

confidence: 99%

Global and regional child mortality and burden of disease attributable to zinc deficiency

2008

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Biochemical Studies on Dwarfism,Hypogonadism, and Anemia

Cited by 308 publications

References 19 publications

Zinc deficiency as a practical problem in plant and human nutrition in Turkey: A NATO-science for stability project

Zinc deficiency as a practical problem in plant and human nutrition in Turkey: A NATO-science for stability project

Low-dose weekly supplementation of iron and/or zinc does not affect growth among Bangladeshi infants

Global and regional child mortality and burden of disease attributable to zinc deficiency

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