Biochemical responses in aquatic animals: A review of determinants of oxidative stress

Giulio, Richard T. Di; Washburn, Peter C.; Wenning, Richard J.; Winston, Gary W.; Jewell, Catherine S.E.

doi:10.1002/etc.5620081203

Cited by 513 publications

(108 citation statements)

References 134 publications

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“…Our results are in agreement with those of SaintDenis et al (1998) on earthworm species Eisenia fetida, wherein catalase activity increased with age, and also in Arenicola, where CAT activity is higher in older compared to younger lugworms (Buchner et al 1996). Previous studies by Di Giulio et al (1989) indicated that CAT activity could be induced under conditions of oxidative stress. However, the CAT activity is altered by a number of other conditions, including changing nutritional status or oxygen status (Livingstone et al 1992).…”

Section: Discussionsupporting

confidence: 93%

Antioxidant enzyme activities and markers of oxidative stress in the life cycle of earthworm,Eudrilus eugeniae

Kiran

Aruna²

2010

Italian Journal of Zoology

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The main aim of this work is to provide basic data on the aspects of pro-oxidant and antioxidant processes in different life stages of Eudrilus eugeniae. The levels of antioxidant enzymes, superoxide dismutase (SOD) and catalase (CAT), along with the byproducts of lipid and protein oxidation, malondialdehyde (MDA) and protein carbonyl (PC), content were determined in the whole body of juvenile, sub-adult and adult earthworms. The SOD activity significantly (P < 0.05) decreased during development from juvenile to adult, while CAT activity showed an increase with advancing age. The MDA content significantly increased in the adult compared to other age groups. The protein carbonyl content showed insignificant changes with respect to age. Our results suggest that the decline in SOD activity coupled with increased levels of MDA implicate the susceptibility of older animals to oxidative stress.

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Section: Discussionsupporting

confidence: 93%

Antioxidant enzyme activities and markers of oxidative stress in the life cycle of earthworm,Eudrilus eugeniae

Kiran

Aruna²

2010

Italian Journal of Zoology

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“…In this context, cytochrome P450-dependent monooxygenase induction, measured as ethoxyresorufin O-deethylase (EROD) activity, has been widely used as a sensitive indicator of exposure to environmental contaminants (Addison et al, 1994;Martel et al, 1994;Pacheco and Santos, 1999). The activation of certain xenobiotics results in the production of potentially damaging oxyradicals, which react with many biological molecules including DNA (Di Guilio et al, 1989). Thus, DNA integrity can be affected.…”

Section: Introductionmentioning

confidence: 99%

Biotransformation, genotoxic, and histopathological effects of environmental contaminants in European eel (Anguilla anguilla L.)

Pacheco

Santos

2002

Ecotoxicology and Environmental Safety

267

125

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A prolonged toxicity study was carried out in young European eel (Anguilla anguilla L.) to evaluate the effects of environmental contaminants, namely, two individual standard compounds, benzo [a]pyrene (BaP) and dehydroabietic acid (DHAA), and a complex mixture, bleached kraft pulp mill effluent (BKPME). Fish were exposed to BaP (0.22, 0.45, and 0.9 mM) and BKPME (3.12%, 6.25%, and 12.5% (v/v)) for 3, 7, and 30 days and to DHAA (0.07, 0.15, and 0.30 mM) for 3, 7, 30, 90, and 180 days. The biomarkers include biotransformation and genotoxicity indicators, such as total ethoxyresorufin O-deethylase (EROD) activity and frequency of erythrocytic nuclear abnormalities (ENAs), respectively. Hematological dynamics was assessed as frequency of immature erythrocytes (IEs). Histopathological examinations were carried out for the highest concentrations and for 30 days and longer exposures. Total EROD increases significantly only after 180 days of DHAA exposure. However, significant ENA induction was generally observed during exposure to all contaminants tested. Nevertheless, some of the ENA results suggest an altered genotoxic response, which may arise either from short-term exposures to the highest contaminant levels or long-term exposures to the lowest contaminant levels. IE frequency decreased significantly after 30 days of exposure to 0.45 mM BaP and 180 days of exposure to the entire DHAA concentration range. Increased density of pigmented macrophage aggregates in 30-day BaP-and BKPME-exposed fish as well as in 90-and 180-day DHAA-exposed fish confirmed histopathological liver alterations. Bile accumulation in hepatocytes after BaP treatment, cytoplasmic vacuolization and cell atrophy following DHAA exposure, as well as liver loss of parenchymal cells in BKPME-exposed fish, were also detected. Dispersed necrosis and focal inflammation were observed in the livers of all treated groups. Fish exposed to DHAA and BKPME showed skin and gill disruption as well as kidney Malpighian corpuscle alterations. All 30-day-treated groups revealed intense spleen hemosiderosis, indicating increased erythrophagia. This splenic effect may be strongly correlated with the observed disappearance of ENAs. Neoplastic lesions were not found. A multibiomarker strategy, which includes EROD, ENA, and IE assays as well as histopathological studies, contributed to a better understanding of the global toxic process. r

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“…Lipid peroxidation is essentially a toxic response to oxidative damage to cellular and tissue components (Di Giulio et al 1989). Increased ROS generation in tissues leads to the oxidation damage to polyunsaturated lipids (lipid peroxidation), proteins and DNA (Storey 1996).…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress in the gill tissues of goldfishes (Carassius auratus) parasitized by Dactylogyrus spp

Mozhdeganloo

Heidarpour

2013

J Parasit Dis

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The aim of this study was to investigate the status of oxidative stress in the gill tissues of goldfishes (Carassius auratus) parasitized by Dactylogyrus spp. We therefore compared the concentrations of malondialdehyde (MDA) and total thiol groups in the gill tissues of parasitized and non-parasitized goldfishes. 15 goldfishes parasitized by Dactylogyrus spp. along with 15 nonparasitized goldfishes were selected for the study. A significant increase in MDA concentration (P \ 0.01) and a significant decrease in total thiol groups in the parasitized group, were observed when compared to the non-parasitized group. This is the first study which evaluates the effect of Dactylogyrus spp. on the oxidative stress status of goldfish. The results of the present study revealed that parasitized goldfishes showed more severe oxidative stress and lipid peroxidation than non-parasitized fishes and enhanced lipid peroxidation may be linked to gill damage in goldfishes parasitized by Dactylogyrus spp.

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Biochemical responses in aquatic animals: A review of determinants of oxidative stress

Cited by 513 publications

References 134 publications

Antioxidant enzyme activities and markers of oxidative stress in the life cycle of earthworm,Eudrilus eugeniae

Antioxidant enzyme activities and markers of oxidative stress in the life cycle of earthworm,Eudrilus eugeniae

Biotransformation, genotoxic, and histopathological effects of environmental contaminants in European eel (Anguilla anguilla L.)

Oxidative stress in the gill tissues of goldfishes (Carassius auratus) parasitized by Dactylogyrus spp

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