Biochemical pregnancy and spontaneous abortion in first IVF cycles are negative predictors for subsequent cycles: an over 10,000 cases cohort study

Abstract

BP and SA in first IVF cycles had negative predictive value for subsequent ART outcomes.

Cumulative live birth rates following miscarriage in an initial complete cycle of IVF: a retrospective cohort study of 112 549 women

“…Previous studies have reported chance of live birth in IVF after miscarriage, but did not report CLBRs. Some reported the results of one subsequent cycle rather than CLBRs over multiple subsequent cycles (Croucher et al 1998, Kalu et al 2011, Yang et al 2015, while others reported live birth rate per oocyte retrieval, but could not report cumulative rates as there was no connection between woman and cycle (Kupka et al 2004). CLBRs report success over complete cycles of continued treatment more accurately than single cycle live birth rates, and are seen as a better measure for counselling couples on chances of success in future cycles (Stern et al 2010).…”

“…Previous work has identified some of the risk factors associated with miscarriage including increasing maternal age (Baker et al 2010, Croucher et al 1998, Hipp et al 2016, previous miscarriages and polycystic ovary syndrome (Joham et al 2014, Knudsen et al 1991, Kupka et al 2004, Rai and Regan 2006. IVF-specific risk factors include the transfer of cryopreserved embryos, cleavage-stage embryo transfer, decreased response to ovarian stimulation (linked to maternal age), previous miscarriages in IVF conceptions and certain causes of infertility such as uterine factor and endometriosis (Croucher et al 1998, Hipp et al 2016, Kupka et al 2004, Yang et al 2015.…”

“…Of the existing studies on miscarriage following IVF, only a handful have reported on the effect of a previous miscarriage on subsequent success rates (Croucher et al 1998, Kalu et al 2011, Kupka et al 2004, Yang et al 2015. Both Kupka et al, (2004) and Yang et al, (2015) reported overall IVF related clinical pregnancy rates and miscarriage rates following miscarriage. Kupka et al, (2004) reported these following any history of previous miscarriage, while Yang et al, (2015) studied success rates after miscarriage in the first embryo transfer.…”

“…Both Kupka et al, (2004) and Yang et al, (2015) reported overall IVF related clinical pregnancy rates and miscarriage rates following miscarriage. Kupka et al, (2004) reported these following any history of previous miscarriage, while Yang et al, (2015) studied success rates after miscarriage in the first embryo transfer. However, they did not compare cumulative live birth rates of those who had a miscarriage with those who had a live birth or those who did not get pregnant over multiple cycles, therefore not reflecting the ongoing, cyclical nature of IVF treatment.…”

Impact of Kuntai Capsules on LIF, IGF-1 and EGF Expression in the Implantation Window of Endometrium in Mice

“…has not yet gained popularity due to low clinical pregnancy rate [5][6]. According to relevant literatures, 60% of all failures of in vitro fertilization-embryo transfers (IVF-ETs) are attributed to diminished endometrial receptivity [7].…”