Cumulative live birth rates following miscarriage in an initial complete cycle of IVF: a retrospective cohort study of 112 549 women

Cameron, N J; Bhattacharya, Siladitya; Bhattacharya, Sohinee; McLernon, David J.

doi:10.1093/humrep/dex293

Cited by 17 publications

(10 citation statements)

References 22 publications

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“…Today, the choice between ICSI and standard IVF is mainly based on the results of a conventional semen analysis, the concentration and motility of the spermatozoa in the raw semen sample as well as after gradient centrifugation or a swim-up procedure (9). Other factors, such as poor fertilization/outcomes by standard IVF, may lead to a switch to ICSI in subsequent cycles (10)(11)(12)(13)(14).…”

mentioning

confidence: 99%

Sperm DNA fragmentation index and cumulative live birth rate in a cohort of 2,713 couples undergoing assisted reproduction treatment

Vončina

Stenqvist

Bungum³

et al. 2021

Fertility and Sterility

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Objective: To study how the choice of the first assisted reproductive technology treatment type affects the cumulative live birth rate (CLBR) in couples with high sperm DNA fragmentation index (DFI). Design: Longitudinal cohort study. Setting: University-affiliated fertility clinic. Patient(s): A total of 2,713 infertile couples who underwent assisted reproductive technology treatment between 2007 and 2017 were included in the study. All in vitro fertilization (IVF)/intracytoplasmic sperm injection (ICSI) treatments (up to three fresh treatments and all associated frozen-thawed embryo transfers) offered to the couples by the public health care system were included, in total 5,422 cycles. Intervention(s): None. Main Outcome Measure(s): The primary outcome was the CLBR. The secondary outcomes were the fertilization rate and the miscarriage rate. The IVF and ICSI groups were defined according to the method applied in the first treatment cycle. Result(s): In the IVF group, the CLBR values were higher for couples with normal DFI compared with those for couples with high DFI (R20%) (48.1% vs. 41.6% for conservative CLBR estimate and 55.6% vs. 51.4% for optimal CLBR estimate after adjustment for female age, respectively). No DFI-dependent difference was seen in the ICSI group. Conclusion(s):Our results demonstrated that a high DFI predicts a statistically significantly lower CLBR if IVF and not ICSI is applied in the first cycle of assisted reproduction.

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mentioning

confidence: 99%

Sperm DNA fragmentation index and cumulative live birth rate in a cohort of 2,713 couples undergoing assisted reproduction treatment

Vončina

Stenqvist

Bungum³

et al. 2021

Fertility and Sterility

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“…In ART, miscarriage is the main threat to successful fertility treatment. 32 Thus, when clinical pregnancy has been achieved, the risk of miscarriage should be evaluated. In particular, during IVF, most reports have cited differences in success rates in clinical pregnancies and live births.…”

Section: The Importance Of Preventing Miscarriagementioning

confidence: 99%

Acupuncture and Chinese Herbal Medicine Effects on Assisted Reproductive Technology: Six Cases and Their Clinical Significance

Jiang

Wan

et al. 2019

Medical Acupuncture

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Background: Assisted reproductive technology (ART) is the routine treatment for infertility. The success rate for individual sessions is generally not high, and many patients need to undergo several cycles. To increase their chances of success, many patients turn to acupuncture to complement ART. Many clinical trials of acupuncture helping in vitro fertilization (IVF) have focused only on IVF-embryo transfer (ET). In some difficult cases, when even IVF cannot be offered, acupuncture and Chinese herbs can improve the patients' conditions to reach a level at which ART can be successful. Cases: Six cases showed how acupuncture and Traditional Chinese Medicine (TCM), using Chinese herbs, can make IVF possible in difficult cases and how they can also help prevent miscarriage afterward. The cases included patients with amenorrhea, sperm disorders, polycystic ovary syndrome, diminished ovarian reserve (DOR), tubal blockage, premenopause, and premature ovarian insufficiency. Results: Acupuncture and Chinese herbs worked together to help make ART possible or easier. The ART used for these patients included intrauterine insemination, IVF, IVF with a donor egg, and introcytoplasmic sperm injection. In 3 cases, IVF was not initially successful but was successful after TCM treatment. Conclusions: These 6 cases demonstrated the positive effect of a combined approach, using acupuncture and herbs to reduce DOR and regulate hormonal disorders, creating sustainable environments for conceiving and maintaining pregnancy, thus, translating into clinical success. Clinical observation of these cases sheds new light on designing future clinical trials and practice of TCM for practitioners who provide infertility treatments.

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“…14 The specific cause of subfertility may also affect the miscarriage rate: women with, for example, certain congenital uterine anomalies, 15 fibroids 16 and some endocrine disorders, 17 have higher rates of miscarriage than do those without. Although women who miscarry following ART can generally be reassured that they are more likely to have a live birth in subsequent cycles than if they had never conceived, 18 as in the general population, some women undergoing ART may also experience recurrent miscarriage. The management of women with both sporadic and recurrent miscarriage in the ART population is no different to that of women in the general population and has been covered elsewhere.…”

Section: Miscarriagementioning

confidence: 99%

Antenatal management of singleton pregnancies conceived using assisted reproductive technology

Richardson

Taylor

Teoh³

et al. 2019

The Obstetric & Gynaecologis

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Use of assisted reproductive technology (ART) to achieve conception is increasing worldwide, and while the majority of resulting pregnancies will have a normal outcome, not all do. Assisted conceptions are at increased risk of maternal and fetal complicationsmany of which may be underappreciated or indeed overappreciated by those who go on to look after pregnant women. Healthcare professionals involved in the antenatal care of women who have conceived using ART must understand the potential risks, their significance and how best to monitor them. Learning objectives To understand the maternal complications associated with ART, including ovarian hyperstimulation syndrome, miscarriage, ectopic pregnancy, pregnancy-induced hypertension, pre-eclampsia, gestational diabetes and venous thromboembolism. To understand the fetal complications associated with ART, including genetic and chromosomal disorders, structural abnormalities, growth restriction, stillbirth and preterm labour. To establish an evidence-based approach to the antenatal management of singleton pregnancies conceived using ART.

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Cumulative live birth rates following miscarriage in an initial complete cycle of IVF: a retrospective cohort study of 112 549 women

Cited by 17 publications

References 22 publications

Sperm DNA fragmentation index and cumulative live birth rate in a cohort of 2,713 couples undergoing assisted reproduction treatment

Sperm DNA fragmentation index and cumulative live birth rate in a cohort of 2,713 couples undergoing assisted reproduction treatment

Acupuncture and Chinese Herbal Medicine Effects on Assisted Reproductive Technology: Six Cases and Their Clinical Significance

Antenatal management of singleton pregnancies conceived using assisted reproductive technology

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