Biochemical Pharmacology of TRPV1: Molecular Integrator of Pain Signals

Surowy, Carol S.; Kym, Philip R.; Reilly, Regina M.

doi:10.1002/9780470588284.ch3

Cited by 4 publications

(5 citation statements)

References 176 publications

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“…Cough severity as assessed by VAS and LCQ, was not associated with increased airway gene or protein expression of TRPV-1 and TRPA-1 statistically or clinically in terms of minimal important difference (MID) in patients with IPF or CC (data not shown). In addition, there was no association between cough severity and lung function measurements in any group in keeping with previous studies (data not shown) [ 9 ].…”

Section: Resultssupporting

confidence: 90%

“…The capsaicin receptor is a member of the transient receptor potential (TRP) family of ion channels known as transient receptor potential vanniloid-1 (TRPV-1) [ 10 , 11 ]. TRPV-1 is a poly-modal channel which is predominantly expressed in sensory afferent fibres and is activated by capsaicin, noxious stimuli and heat [ 9 , 10 ]. Immuno-histochemical (IHC) studies comparing bronchial biopsies from patients with and without chronic cough identified a significant increase of TRPV-1 staining nerve profiles, which was positively correlated with capsaicin tussive response [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Airway expression of Transient Receptor Potential (TRP) Vanniloid-1 and Ankyrin-1 channels is not increased in patients with Idiopathic Pulmonary Fibrosis

et al. 2017

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Dry cough is a common symptom described in patients with Idiopathic Pulmonary Fibrosis (IPF) and impairs quality of life. The exact mechanisms causing cough in IPF remain unclear, however evidence suggests altered cough neurophysiology and sensitisation plays a role; IPF patients have an enhanced cough reflex sensitivity to inhaled capsaicin. The Transient Receptor Potential Vanniloid-1 channel (TRPV-1) has a role in the cough reflex and airway expression is increased in patients with chronic cough. The Ankyrin-1 receptor (TRPA-1) is often co-expressed. It was hypothesised that, like chronic cough patients, IPF patients have increased airway TRP receptor expression. Bronchial biopsies were obtained from 16 patients with IPF, 11 patients with idiopathic chronic cough and 8 controls without cough. All other causes of cough were rigorously excluded. Real-time quantitative Polymerase Chain Reaction was used to detect TRPV-1 and TRPA-1 mRNA expression with Immunohistochemistry demonstrating protein expression. Mean TRPV-1 and TRPA-1 gene expression was higher in IPF patients compared with controls, but the difference did not reach statistical significance. Immunostaining supported these findings. This study suggests that structural up-regulation of central airway TRP receptors is not the key mechanism for cough in IPF patients. It is probable that IPF cough results from altered neuronal sensitivity at multiple levels of the cough pathway.

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Section: Resultssupporting

confidence: 90%

Section: Introductionmentioning

confidence: 99%

Airway expression of Transient Receptor Potential (TRP) Vanniloid-1 and Ankyrin-1 channels is not increased in patients with Idiopathic Pulmonary Fibrosis

et al. 2017

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“…[24][25][26][27][28][29][30] These mediators may activate TRPV1 directly (bradykinin) or activate protein kinases A and C, which can phosphorylate and thus sensitize the receptor. 12,13,[30][31][32][33][34][35][36] Had the analgesic efficacy of ABT-116 been evaluated by use of an inflammatory model in the present study, efficacy may have been detected in response to thermal threshold testing.…”

Section: Discussionmentioning

confidence: 99%

Comparison of the analgesic efficacy of oral ABT-116 administration with that of transmucosal buprenorphine administration in dogs

Niyom

Mama²,

Rezende³

2012

ajvr

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“…Transient receptor potential vanilloid receptors (TRPVs) are mechanosensitive channels highly associated with nervous system functions including pain, memory, and mechanical sensations. Furthermore, capsaicin receptor TRPV1 is a key regulator of pain and inflammation and is upregulated in microglia in the brain, especially in the anterior cingulate cortex [138][139][140]. The stimulation of microglial TRPV1 induces cortical microglial activation and indirectly enhances glutamatergic neuronal transmission by promoting the shedding of extracellular microglial microvesicles (release of vesicles in the extracellular space [141]).…”

Section: Trpv1 and The P38 Pathwaymentioning

confidence: 99%

“…This signal transduction can be inhibited by the p38 MAPK inhibitor SB203580. Thus, p38 MAPK is a downstream TRPV1 activator whose phosphorylation plays an essential role in microglial microvesicle shedding by activating P2X purinoceptor 7 (P2X7) ATP receptor [138][139][140][141][142][143]. Whereas TRPV1 mediates communication between microglia and neurons, inhibition of the phosphorylation of its downstream p38 MAPK inhibits sphingosine metabolism [140][141][142][143].…”

Section: Trpv1 and The P38 Pathwaymentioning

confidence: 99%

Effect of Acupuncture on the p38 Signaling Pathway in Several Nervous System Diseases: A Systematic Review

Wei

Hsieh

2020

IJMS

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Acupuncture is clinically used to treat various diseases and exerts positive local and systemic effects in several nervous system diseases. Advanced molecular and clinical studies have continually attempted to decipher the mechanisms underlying these effects of acupuncture. While a growing understanding of the pathophysiology underlying several nervous system diseases shows it to be related to inflammation and impair cell regeneration after ischemic events, the relationship between the therapeutic mechanism of acupuncture and the p38 MAPK signal pathway has yet to be elucidated. This review discusses the latest advancements in the identification of the effect of acupuncture on the p38 signaling pathway in several nervous system diseases. We electronically searched databases including PubMed, Embase, and the Cochrane Library from their inception to April 2020, using the following keywords alone or in various combinations: “acupuncture”, “p38 MAPK pathway”, “signaling”, “stress response”, “inflammation”, “immune”, “pain”, “analgesic”, “cerebral ischemic injury”, “epilepsy”, “Alzheimer’s disease”, “Parkinson’s disease”, “dementia”, “degenerative”, and “homeostasis”. Manual acupuncture and electroacupuncture confer positive therapeutic effects by regulating proinflammatory cytokines, ion channels, scaffold proteins, and transcription factors including TRPV1/4, Nav, BDNF, and NADMR1; consequently, p38 regulates various phenomena including cell communication, remodeling, regeneration, and gene expression. In this review article, we found the most common acupoints for the relief of nervous system disorders including GV20, GV14, ST36, ST37, and LI4. Acupuncture exhibits dual regulatory functions of activating or inhibiting different p38 MAPK pathways, contributing to an overall improvement of clinical symptoms and function in several nervous system diseases.

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Biochemical Pharmacology of TRPV1: Molecular Integrator of Pain Signals

Cited by 4 publications

References 176 publications

Airway expression of Transient Receptor Potential (TRP) Vanniloid-1 and Ankyrin-1 channels is not increased in patients with Idiopathic Pulmonary Fibrosis

Airway expression of Transient Receptor Potential (TRP) Vanniloid-1 and Ankyrin-1 channels is not increased in patients with Idiopathic Pulmonary Fibrosis

Comparison of the analgesic efficacy of oral ABT-116 administration with that of transmucosal buprenorphine administration in dogs

Effect of Acupuncture on the p38 Signaling Pathway in Several Nervous System Diseases: A Systematic Review

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