Biochemical Pathologies of Zinc Deficiency

Clegg, Michael S.; Keen, Carl L.; Hurley, Lucille S.

doi:10.1007/978-1-4471-3879-2_9

Cited by 26 publications

(14 citation statements)

References 98 publications

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“…The severe type shows severe immune impairment, frequent infections, pustular-bullous dermatitis, diarrhoea, alopecia and mental disturbances (Walsh et al, 1994;Kay & Tasman-Jones, 1975). Similar effects are found in animals with zinc defi ciency (Walsh et al, 1994;Zalewski, 1996;Clegg, Keen & Hurley, 1989). Acrodermatitis enteropatica is the prototype of a disease due to zinc defi ciency.…”

Section: Introductionmentioning

confidence: 89%

Is there a relationship between zinc and the peculiar comorbidities of Down syndrome?

Romano¹,

Pettinato²,

Ragusa³

et al. 2002

Downs Syndr. Res. Pract.

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Zinc plays a central role in the immune system and has been found to be signifi cantly reduced in people with Down syndrome. The effectiveness of zinc supplementation in people with Down syndrome has been reported with discordant results. A comparison was made between a range of clinical and biochemical variables and zinc levels in 120 individuals with Down syndrome. Two groups of participants, one with normal zinc levels and the second with low zinc levels, were compared on the following measures: growth hormone secretion, IgA and IgG antigliadin antibodies, presence of coeliac disease, T3, T4, fT3, fT4, TSH, hypothyroidism, hyperthyroidism, CD4/CD8 ratio, total immunoglobulins G and subclasses. No signifi cant difference was found between the two groups, except for IgG4 which was, unexpectedly, signifi cantly decreased in the group with normal zinc levels. In conclusion, an impairment of zinc blood level in individuals with Down syndrome does not necessarily impact on the organs and systems evaluated here.

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Section: Introductionmentioning

confidence: 89%

Is there a relationship between zinc and the peculiar comorbidities of Down syndrome?

Romano¹,

Pettinato²,

Ragusa³

et al. 2002

Downs Syndr. Res. Pract.

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“…Severe zinc deficiency can result in anorexia, growth retardation, abnormal immune function, impaired reproductive capacity, skin lesions, and behavioral defects (14). Whereas severe Zn deficiency may be a rare occurrence in human populations, marginal Zn deficiency can be a relatively common problem in both humans and domestic animals, depending on their diet and physiological condition (36).…”

Section: Zincmentioning

confidence: 99%

Essential Trace Elements in Antioxidant Processes

Zidenberg‐Cherr¹,

Keen²

1991

Trace Elements, Micronutrients, and Free Radicals

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The antioxidant defense system is comprised of a number of interconnecting, and overlapping, components that include both enzymatic and nonenzymatic factors. The trace elements eu, Zn, and Mn are critical components for a number of these processes, and a deficiency of anyone of these elements can result in an impairment of the functioning of the overall antioxidant system. This impairment can be physiologically significant, particularly if the animal is exposed to environmental challenges that increase the production of oxygen radicals over normal physiological levels.

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“…Anorexia has been linked to altered protein metabolism, in particular, imbalance in amino acids (WALLWORK et al, 1981;O'DELL & REEVES, 1989;CLEGG et al, 1989).…”

Section: Discussionmentioning

confidence: 99%

Food preference of young rhesus monkeys fed marginally zinc deficient diets

et al. 1991

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ABSTRACT. Zinc deprivation has been shown to produce hypogeusia in rhesus monkeys but the possible consequences of altered taste sensitivity for food preference and selection is not known. We studied 13 rhesus monkeys (2.5 to 3 years of age) for food preference in a structured choice situation. These animals were fed two levels of dietary zinc: marginally zinc deprived (fed 4 #g zinc/g diet from conception and throughout development; N=6), or control (fed a 100 #g zinc/g diet throughout the study; N= 7). Preference for familiar vs unfamiliar food items, order of food preferences, persistence in retrieval of preferred and nonpreferred foods, and preference under four deprivation periods were examined. Animals were offered a choice of two food items, both containing minimal zinc levels, and food choice and latency of choice were measured. Results indicate that animals fed the marginal zinc diets had reduced preference for unfamiliar foods relative to controls and different patterns of food preference. These results may be relevant to maintenance of appropriate food selection in marginally zinc deprived populations.

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Biochemical Pathologies of Zinc Deficiency

Cited by 26 publications

References 98 publications

Is there a relationship between zinc and the peculiar comorbidities of Down syndrome?

Is there a relationship between zinc and the peculiar comorbidities of Down syndrome?

Essential Trace Elements in Antioxidant Processes

Food preference of young rhesus monkeys fed marginally zinc deficient diets

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