Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study

Vulpen, Lize F D van; Meegeren, M.E.R. van; Roosendaal, G.; Jansen, N.W.; Laar, J.M. van; Schutgens, Roger E. G.; Mastbergen, S.C.; Lafeber, Floris P. J. G.

doi:10.1016/j.joca.2014.09.008

Cited by 62 publications

(63 citation statements)

References 36 publications

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“…The impact of blood exposure on extracellular matrix turnover is demonstrated in HA patients, showing an increase in biomarkers of joint tissue turnover upon a joint bleed 53. Interestingly, iron removal seems to impact extracellular matrix turnover.…”

Section: Histopathologymentioning

confidence: 96%

The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia

et al. 2015

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Joint damage due to (recurrent) joint bleeding in haemophilia causes major morbidity. Although the exact pathogenesis has not been fully elucidated, a central role for iron is hypothesised. Likewise, in hereditary haemochromatosis joint destruction is caused by iron overload. A comparison between these types of arthropathy could provide more insight in the influence of iron in inducing joint damage. A literature review was performed to compare both disorders with respect to their clinical and histological characteristics, and preclinical studies on the influence of iron on different joint components were reviewed. Similarities in the features of arthropathy in haemochromatosis and haemophilia are cartilage degeneration, subchondral bone changes with osteophyte and cyst formation, and osteoporosis. In both disorders synovial inflammation and proliferation are seen, although this is much more explicit in haemophilia. Other substantial differences are the age at onset, the occurrence of chondrocalcinosis radiographically and calcium pyrophosphate dihydrate deposition disease in haemochromatosis, and a rapid progression with joint deformity and neovascularisation in haemophilia. Preclinical studies demonstrate detrimental effects of iron to all components of the joint, resulting in synovial inflammation and hyperplasia, chondrocyte death, and impaired osteoblast function. These effects, particularly the synovial changes, are aggravated in the presence of a pro-inflammatory signal, which is prominent in haemophilic arthropathy and minimal in haemochromatosis. Additional research is needed to further specify the role of iron as a specific target in treating these types of arthropathy.

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Section: Histopathologymentioning

confidence: 96%

The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia

et al. 2015

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“…[1][2][3] Over the years, evidence has been gathered that even a single exposure of blood to a joint has profound damaging effects on joint cartilage. [4][5][6] This devastating effect is not primarily the result of synovial inflammation induced by blood components, an important aspect of repeated bleeding as in hemophilia. After a single bleeding, these synovial effects are considered transient, 7 whereas effects on cartilage are devastating.…”

Section: Introductionmentioning

confidence: 99%

IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy

Vulpen

Schutgens²,

Coeleveld

et al. 2015

Blood

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“…10,11 Circulating levels of COMP are elevated in patients with radiographically apparent OA and increase as the OA burden increases. 18,24 COMP was also shown useful in evaluation and monitoring the impact of joint tissue damage as joint bleed, 25 as femoroacetabular impingement in athletes. 26 In this study work we could not find any differences among groups in serum COMP.…”

Section: Discussionmentioning

confidence: 99%

Different Sports in Adolescence: Effect on Lipid Profile, Glucose Metabolism, Body Composition, Bone Density, Bone Quality, Bone Markers, Vascular Function and Structure, Pituitary and Hypothalamic Antibodies

GROSSGASTEIGER¹,

Lupi²,

Cappa³

et al. 2015

Sport Exerc Med Open J

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ResearchPage 97 ABSTRACT Introduction: Sports can positively influence body health, however expose the athletes also to risks of repetitive trauma, in particular brain trauma. Aim of the study: To evaluate the effects of different sports on glucose metabolism, lipid profile, insulin resistance (HOMA-r) and sensitivity (QUICKI), body composition, bone mass and mineralization (DEXA), bone quality (SOS and BTT), bone metabolism (PiNP, CTX, COMP, DKK1 and sclerostin) vascular structure and function (IMT and FMD) and on the presence of anti-pituitary and anti-hypothalamus antibodies. A health score was also calculated. Patients: We evaluated 80 athletes practicing alpine skiing (#19), ice-hockey (#21), rugby (#20) and swimming (#20). Results: Swimmers showed the highest triglycerides values (p<0.05). Glucose was more elevated in the rugby players (p<0.05) than in skiers and swimmers and insulin also higher in swimmers (p<0.05) than in rugby and hockey players. HOMA-r and QUICKI were significantly higher and lower respectively in swimmers (p<0.05) compared to the hockey players. DKK1 was significantly higher in the hockey players (p<0.05) compared to skiers and swimmers. FMD was significantly higher in hockey (p<0.05) and rugby players (p<0.05) compared to swimmers. Bone quality (BTT) was better in the skiers (p<0.05) compared to the hockey players. Antihypothalamus antibodies were not different among groups, while anti-pituitary antibody were significantly more frequent in the hockey players compared to swimmers (p<0.05). The health score was more advantageous in the skiers group. Conclusion: Different sports exert distinct effects. Altogether, alpine skiing seems to produce the most benefits, in particular, because of the positive effects on bone and cardiovascular function.

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Biochemical markers of joint tissue damage increase shortly after a joint bleed; an explorative human and canine in vivo study

Cited by 62 publications

References 36 publications

The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia

The detrimental effects of iron on the joint: a comparison between haemochromatosis and haemophilia

IL-1β, in contrast to TNFα, is pivotal in blood-induced cartilage damage and is a potential target for therapy

Different Sports in Adolescence: Effect on Lipid Profile, Glucose Metabolism, Body Composition, Bone Density, Bone Quality, Bone Markers, Vascular Function and Structure, Pituitary and Hypothalamic Antibodies

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