Biochemical markers of bone metabolism in bone marrow edema syndrome of the hip

Berger, Christian E.; Kröner, A.; Minai-Pour, Michael; Ogris, E; Engel, A.

doi:10.1016/s8756-3282(03)00164-9

Cited by 79 publications

(62 citation statements)

References 27 publications

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“…The authors postulated that the high expression of VEGF and CYR61 in the lesion could be caused by hypoxia, indicating a role of these proteins in the repair processes ongoing in osteonecrosis [16]. However, the increased levels could also be a consequence of increased bone turnover, which would Wt the increased levels of bone markers in the study of Berger et al [15]. Another study reported positive immunoreactivity for TNF-alpha, IL-6, RANKL, OPG and OPN in bone marrow and bone of RA patients [17].…”

Section: Histologymentioning

confidence: 98%

“…In 37 consecutive patients undergoing core decompression of the femoral head, biochemical markers of bone turnover were measured in needle aspirates from cancellous bone and in samples obtained simultaneously from peripheral blood [15]. Levels of bone-speciWc alkaline phosphatase (bone ALP), osteocalcin (OC), procollagen Type I N-terminal propeptide (PINP) and C-terminal cross-linking telopeptide (ICTP) were assessed in serum and marrow aspirates.…”

Section: Histologymentioning

confidence: 99%

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Bone marrow lesions: a universal bone response to injury?

Eriksen

Ringe

2011

Rheumatol Int

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The ever increasing use of magnetic resonance imaging in clinical practice has led to the recognition of a new entity, bone marrow lesions (BMLs). These lesions are characterized by excessive water signals in the marrow space and have emerged as a central component of many different diseases affecting the musculoskeletal system. BMLs have in particular been associated with a wide variety of inflammatory and non-inflammatory rheumatologic conditions and are not only considered significant sources of pain, but also linked to the worsening of patient prognosis in many disease states. In this review, we summarize the current knowledge on BMLs with an emphasis on the clinical and histological features of this entity in inflammatory and non-inflammatory disease and provide a unifying hypothesis based on the appearance with various imaging technologies. We also try to pair this hypothesis with the apparent beneficial effects of various treatment regimens, mainly within the group of bone antiresorptive drugs (calcitonin, bisphosphonates) on symptoms associated with BMLs.

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Section: Histologymentioning

confidence: 98%

Section: Histologymentioning

confidence: 99%

Bone marrow lesions: a universal bone response to injury?

Eriksen

Ringe

2011

Rheumatol Int

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“…11,12 Analyses of needle aspirates from cancellous bone marrow have shown sign of high turnover in BML as reflected in significantly elevated levels of bone markers (Bone-specific alkaline phosphatase, osteocalcin, procollagen Type I N-terminal propeptide and C-terminal cross-linking telopeptide (ICTP)) with 4-16-fold higher values than measured in serum. 13 Increased expression of angiogenesis factors (VEGF, CYR61 and CTGF) has also been demonstrated in BML, and it has been postulated that the elevated levels indicated a role of these proteins in the repair processes in osteonecrosis. 14 However, the increased levels could also be a consequence of increased bone turnover.…”

Section: Imagingmentioning

confidence: 99%

Treatment of bone marrow lesions (bone marrow edema)

Eriksen

2015

BoneKEy Reports

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Bone marrow lesions (BMLs) or using older terminology 'Bone marrow edema' is characterised by excessive water signals in the marrow space on magnetic resonance imaging or ultrasound; BMLs constitute a central component of a wide variety of inflammatory and non-inflammatory rheumatologic conditions affecting the musculoskeletal system: BMLs are not only considered significant sources of pain but also linked to increased disease activity in many musculoskeletal conditions (for example, osteoarthritis, rheumatoid arthritis). The purpose of this review is to summarise current knowledge about the treatment of BMLs, with an emphasis on the clinical and histological features of this entity in inflammatory and non-inflammatory disease. We also try to pair this hypothesis with the apparent beneficial effects of various treatment regimens, mainly within the group of bone antiresorptive drugs (calcitonin, bisphosphonates) on symptoms associated with BMLs.

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“…Eine mögliche Progredienz vom KMÖS zur ON ist teilweise umstritten [32,46]; eine separate Entität beider Erkrankun gen wird jedoch jüngst gefordert [10,33]. Der Beitrag verschafft einen Überblick; eine vollständige Erfassung der einzelnen komplexen Krankheitsbilder würde den Rahmen jedoch sprengen.…”

Section: » Knochenmarködeme Treten Am Häufigsten Am Proximalen Femur Aufunclassified

Knochenmarködem und atraumatische Femurkopfnekrose

et al. 2015

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The differentiation of at least 3 different etiologies is proposed (mechanic, reactive and ischemic). Difficult, but important, is the distinction between the mostly painful, but benign entities (BME syndrome, bone bruise) and the progressive pathologies (osteonecrosis, arthritis, CRPS, tumour). Treatment options are dependent on etiology and clinic and can often be symptomatic. Core decompression is the surgical gold standard, leading to immediate pressure relief and therefore reduction in pain. Recently, it was shown that intravenous administration of Iloprost and bisphosphonates are also effective in achieving a reduction of BME and pain, with considerable improvement in the accompanying symptoms. The combination of core decompression and infusion seems to be another possible optimization ofthe therapy, in particular in the treatment of osteonecrosis.

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Biochemical markers of bone metabolism in bone marrow edema syndrome of the hip

Cited by 79 publications

References 27 publications

Bone marrow lesions: a universal bone response to injury?

Bone marrow lesions: a universal bone response to injury?

Treatment of bone marrow lesions (bone marrow edema)

Knochenmarködem und atraumatische Femurkopfnekrose

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