Biochemical indicators of nephrotoxicity in blood serum of rats treated with novel 4-thiazolidinone derivatives or their complexes with polyethylene glycol-containing nanoscale polymeric carrier

Indicators of oxidative and nitrosative stress and activity of enzymes of nitric oxide metabolism in rats treated with 4-thiazolidinone derivatives possessing antineoplastic activity

“…In vivo study (rats) of the biochemical indicators of cardio- [26], hepato- [13] and nephrotoxic [27] actions of the applied drugs showed the same ranking. In this study, we have found that the increased level of ROS and RNS in blood serum of the experimental rats also demonstrated similar ranking.…”

“…The activation of FRO leads to a pathological process causing the frequent intoxication of the organism [13,14]. The results of studying the effect of experimental compounds (4-thiazolidinone derivatives -Les-3288, Les-3833 and Les-3882) on ROS and RNS concentration in blood serum of rats are shown on Fig.…”

“…Both the pro-and anti-apoptotic factors use FRO-modulated pro-and anti-oxidant mechanisms for killing both normal and tumor cells [11,12]. New antineoplastic strategy based on differential induction of FROdependent mechanisms in normal and tumor cells has been proposed [1,11,13]. It should be noted that the use of most existing therapies in oncology is accompanied by the development of harmful effects of FRO on the cells of normal tissues and organs [1,5,6,[11][12][13].…”

“…New antineoplastic strategy based on differential induction of FROdependent mechanisms in normal and tumor cells has been proposed [1,11,13]. It should be noted that the use of most existing therapies in oncology is accompanied by the development of harmful effects of FRO on the cells of normal tissues and organs [1,5,6,[11][12][13]. These negative side effects are mostly caused by ROS and RNS that significantly limits the applied dosage of appropriate anticancer drugs [1,5,6,12,14].…”

“…Cytotoxicity of the above mentioned compounds towards 60 human tumor cell lines has been evaluated, and three compounds (Les-3288, Les-3833 and Les-3882) posses sing high cytotoxic action towards tumor cells were selected for more detailed analysis of the perspectives of their use as the antineoplastic agents. Studies of the biochemical mechanisms of their cytotoxic effects in vitro have been started, and their biocompati bility in vivo has been evaluated [13,14,16]. The results of such study will contribute to a better understanding of the ways of circumventing negative side effects by the oxidative stress appearing at the action of anticancer drugs with maximum preser ving of their therapeutic efficacy.…”