Biochemical genetics of glutathione-s-transferase in man

Board, P.G.

doi:10.1016/s0031-3025(16)38444-6

Cited by 116 publications

(99 citation statements)

References 6 publications

(13 reference statements)

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“…The polymorphism in GSTM1 and GSTT1 gene loci is caused by a gene deletion which results in the absence of enzyme activity in individuals with the GSTT1 and GSTM1 null genotypes. These homozygous null polymorphisms of GSTM1 and GSTT1 may lead to wide inter-individual variations in the metabolic activation of chemical carcinogen (Board, 1981). The polymorphisms of GSTM1, GSTT1 have been associated with cancers of the lung, bladder, breast and colon (Autrup, 2000).…”

Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of GSTM1 and GSTT1 Genes in Delhi and Comparison with other Indian and Global Populations

Sharma¹,

Pandey²,

Sardana³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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The glutathione S-transferases (GSTs) are involved in the metabolism of many xenobiotics, including an array of environmental carcinogens, pollutants, and drugs. Genetic polymorphisms in these genes may lead to interindividual variation in susceptibility to various diseases. In the present study, GSTM1 and GSTT1 polymorphisms were analysed using a multiplex polymerase chain reaction in 500 normal individuals from Delhi. The frequency of individuals with GSTM1 and GSTT1 null genotypes were 168 (33.6%) and 62 (12.4%) respectively, and 54(10.8%) were having homozygous null genotype for both the genes GSTM1 and GSTT1simultaneously. The studied population was compared with reported frequencies from other neighbouring state populations, as well as with those from other ethnic groups; Europeans, Blacks, and Asians. The prevalence of homozygous null GSTM1 genotype is significantly higher in Caucasians and Asians as compared to Indian population. The frequency of GSTT1 homozygous null genotypes is also significantly higher in blacks and Asians. We believe that due to large number of individuals in this study, our results are reliable estimates of the frequencies of the GSTM1, GSTT1 in Delhi. It would provide a basic database for future clinical and genetic studies pertaining to susceptibility and inconsistency in the response and/or toxicity to drugs known to be the substrates for GSTs.

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Section: Introductionmentioning

confidence: 99%

Genetic Polymorphisms of GSTM1 and GSTT1 Genes in Delhi and Comparison with other Indian and Global Populations

Sharma¹,

Pandey²,

Sardana³

et al. 2012

Asian Pacific Journal of Cancer Prevention

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“…These enzymes mainly metabolize chemotherapeutic agents, chemical carcinogens and by-products of oxidative stress, 4 and are absent from more than 50% of some populations. [5][6][7] We analyzed the association between homozygous GSTM1 and GSTT1 gene deletions in the donor or recipient with various outcomes of transplantation and found GSTM1-positive recipients were significantly associated with higher TRM and lower survival. These results suggest that some reactive intermediates or toxic metabolites generated by GSTM1 may initiate or promote the development of TRM.…”

Section: Introductionmentioning

confidence: 99%

Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients

Terakura

Murata

Nishida

et al. 2006

Bone Marrow Transplant

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Treatment-related mortality (TRM) is a major obstacle to successful allogeneic hematopoietic stem cell transplantation (HSCT). A variety of drugs are used in allogeneic HSCT, and a genetic polymorphism in metabolic enzymes could affect the metabolism of drugs and potentially influence TRM. Here, we focused attention on GSTM1 and GSTT1 enzymes, which metabolize chemotherapeutic agents, chemical carcinogens and by-products of oxidative stress and are absent from more than 50% of some populations. To assess the significance of homozygous GSTM1 and GSTT1 gene deletion in HSCT, we analyzed DNA from 373 patients with hematological disease and their HLA-identical unrelated bone marrow donors using PCR. Homozygous GSTM1 and GSTT1 gene deletions were observed in 56 and 45% of patients, respectively, and 57 and 46% of donors, respectively. There was no significant association between GSTT1 polymorphism and any outcome. However, a GSTM1-positive genotype in recipients was significantly associated with higher TRM and lower survival. These results suggest that a GSTM1-null genotype in recipients protects against TRM after allogeneic HSCT. Further studies are needed to elucidate a mechanism of increased risk for TRM in GSTM1-positive recipients.

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“…There are four subclasses in mammalian cells, Alpha, Mu, Pi and Theta (Mannervik et al, 1992). The M1 member of the mu subclass is poly-morphic, being expressed in only 50-60% of Caucasians because of a gene deletion on the 'null' allele (Board et al, 1981a;1981b;Seidegard et al, 1988). Previous studies have shown that the homozygous null genotype is more common among patients with colorectal cancer (Strange et al, 1991;Zhong et al, 1993), squamous cell carcinoma of the lung (Hirvonen et al, 1993), and other lung cancers (Seidegard et al ., 1990;Kihara et al ., 1993).…”

Section: Introductionmentioning

confidence: 99%

Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients

Hong

Chang²,

Kwon³

et al. 1998

Exp Mol Med

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The levels of expressions and catalytic activities of cytochrome P450 (CYP1A1) and glutathione-S-t r a n sferase class (GSTM1) enzymes in lungs and their metabolic balance may be an important determinant host factor underlying lung cancer. Genetic differences in metabolism, MspI restriction sites, Ile-Val polymorphism of CYP1A1 gene, and the null genotype of GSTM1 have been reported to be associated with susceptibility to lung cancer. The present studies were undertaken to establish frequencies of the polymorphic genotypes of CYP1A1 and GSTM1 in Koreans, and to evaluate linkage disequilibrium of the genotypes associated with higher lung cancer risks among Koreans. GSTM1(-) genotype was found in 52% of control subjects, whereas it was found in 55% of lung cancer patients. The allelic variants in CYP1A1 were distributed differently in lung cancer patients and controls. The heterozygous genotype frequency of the MspI site in lung cancer patients (53%) was higher than in controls (49%). The frequency of Ile/Val genotype of CYP1A1 was low in lung cancer patients, which are mostly squamous cell carcinoma.

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Biochemical genetics of glutathione-s-transferase in man

Cited by 116 publications

References 6 publications

Genetic Polymorphisms of GSTM1 and GSTT1 Genes in Delhi and Comparison with other Indian and Global Populations

Genetic Polymorphisms of GSTM1 and GSTT1 Genes in Delhi and Comparison with other Indian and Global Populations

Increased risk for treatment-related mortality after bone marrow transplantation in GSTM1-positive recipients

Polymorphism of the CYP1A1 and glutathione-S-transferase gene in Korean lung cancer patients

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