Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers

Banerjee, Basu Dev; Seth, Vijay K.; Bhattacharya, A. K.; Pasha, Syed Tazeen; Chakraborty, Apala

doi:10.1016/s0378-4274(99)00029-6

Cited by 483 publications

(280 citation statements)

References 23 publications

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“…On account of an elevated level of lipid peroxidation products, pyrethroids may induce oxidative stress. 47 The observation concerning an increase in the serum glutamate-oxalacetate transaminase (SGOT) and serum glutamate-pyruvate transaminase (SGPT) activities (Table 1) is in agreement with the findings of Yousef et al 9,10 and El-Demerdash et al 12 The increase in these serum enzyme activities is suggestive of liver dysfunction. Hence, cellular damage caused by toxic substances is frequently accompanied by increasing cell membrane permeability.…”

Section: Discussionsupporting

confidence: 87%

Dose-Dependent Hematological, Hepatic and Gonadal Toxicity of Cypermethrin in Wistar Rats

Das¹,

Ghosh²,

Paramanik³

et al. 2017

Toxicol Forensic Med Open J

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CitationPesticides are used frequently and may have various adverse effects on human health in different ways. Cypermethrin (CYP) is a synthetic type II pyrethroid pesticide that has been used extensively to control a wide variety of pests in agriculture, forestry, horticulture, and public health. Objectives: This study aimed to investigate the dose-dependent hematological, hepatic and gonadal toxicity of CYP in mature male and female Wistar rats. Methods: Rats were randomly divided into nine groups, different doses of CYP were administered for 14 consecutive days and different hematological, hepatic and gonadal parameters were assayed. Results: Erythrocyte count, hemoglobin percentage, hepatic reduced glutathione (GSH) content and sperm count were significantly diminished. Serum aspartic and alanine transaminase, hepatic malondialdehyde (MDA), testicular cholesterol content were increased following CYP treatment in male rats at 40 and 80 mg/kg body weight (1/9 and 1/4.5 LD 50 ). Elevated ovarian cholesterol content and decreased 17β hydroxy steroid dehydrogenase (HSD) levels were also observed in CYP-exposed female rats at a dose level of 34.33 and 51.5 mg/kg body wt. (1/9 and 1/6 LD 50 ). Conclusion: Taken together, CYP initiated hematological, hepatic and gonadal toxicity in mature male rats with a body weight of 40 mg/kg (1/9 LD 50 ) and gonadal toxicity in mature female rats with a body weight of 34.33 mg/kg (1/9 LD 50 ) and above.

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Section: Discussionsupporting

confidence: 87%

Dose-Dependent Hematological, Hepatic and Gonadal Toxicity of Cypermethrin in Wistar Rats

Das¹,

Ghosh²,

Paramanik³

et al. 2017

Toxicol Forensic Med Open J

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“…Pyrethroids induced oxidative stress by the elevation of lipid peroxidation products. 40,41 Elevated MDA level in LCT intoxicated rat liver was in an agreement with the above statement. This type of result also suggested that LCT produces hepatic injury and pathogenesis through the generation of free radicals and by the alteration of antioxidant system.…”

Section: Discussionsupporting

confidence: 86%

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

Ghosh¹,

Das²,

Paramanik³

et al. 2016

Toxicol Forensic Med Open J

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Extensive application of pesticides is usually accompanied with serious problems of pollution and health hazards. Lambda-cyhalothrin (LCT), a type II synthetic pyrethroid, is widely used in agriculture, home pest control and protection of foodstuff. This study designed to evaluate the dose dependent haematological, hepatic and gonadal toxicity of LCT at different dose levels in Wistar rat. Investigations were also done to find out the toxic effect of lambda cyhalothrin on lipid metabolism in female rat and its amelioration by taurine. Rats were exposed to different doses of lambda cyhalothrin over a period of 14 consecutive days. Exposure to LCT produced ataxia, agitation, rolling and also tremors which were considered as the signs of toxicity. Significant decrease in erythrocyte count, haemoglobin percentage, seminal fructose concentration, hepatic and testicular reduced glutathione (GSH) content was observed. Increase in leukocyte count, serum aspartic and alanine transaminase, hepatic and testicular malondialdehyde (MDA), testicular and ovarian cholesterol after LCT treatment were seen in male rats at the dose level of 10.83 mg/kg body wt. (1/7 th LD 50 ). Elevated ovarian cholesterol and MDA and reduced 3β hydroxy steroid dehydrogenase (HSD) and GSH level were also observed in lambda cyhalothrin exposed female rat at the dose level of 6.29 mg/kg body wt.(1/9 th LD 50 ). LCT caused increase in serum triglyceride, cholesterol, low density lipoproteins (LDL), very low density lipoproteins (VLDL) and bilirubin and decrease in serum high density lipoproteins (HDL) in female rat. Taurine pretreatment ameliorated LCT induced altered lipid metabolic biomarkers in female rat.

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“…Previous studies have reported that exposure to different categories of pesticides induces oxidative stress. 11,24 Uric acid is known to be an antioxidant plasma component. Hence, these observations suggest that the increase of this component in workers may occur in response to an oxidative stress induced by pesticides, but this remains to be confirmed.…”

Section: Discussionmentioning

confidence: 99%

“…10 Exposure to low levels of pesticides may produce a variety of biochemical changes, some of which may be responsible for the adverse biological effects reported in humans and animals. 10,11 Conversely, some biochemical alterations may not necessarily lead to clinically observable symptoms. In recent years, increasing attention has been given to the development of biological markers of human exposure to pesticides.…”

Section: Introductionmentioning

confidence: 99%

Adverse effects of pesticides on biochemical and haematological parameters in Tunisian agricultural workers

Araoud

Neffeti

Douki

et al. 2012

J Expo Sci Environ Epidemiol

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Biomonitoring of effects in agricultural workers is necessary to assess the individual risk of handling pesticides. In this study, biochemical and haematological parameters were measured to evaluate the effects of exposure to these compounds in agricultural workers. The study was carried out in 110 workers and 97 control subjects. Several haematological and biochemical parameters were analysed. Assessment of haematological parameters revealed that the mean cell volume and haematocrit levels were significantly lower in workers than in controls (P ¼ 0.002 and 0.013, respectively), while mean corpuscular haemoglobin concentrations were higher in workers (Po0.001). There was also a significant inhibition of butyrylcholinesterase activity in workers compared with that in controls (Po0.001). Assessment of biochemical parameters further showed significantly higher activities of transferases, lactate dehydrogenase (Po0.001), alkaline phosphatase (ALP) (P ¼ 0.006) and creatine kinase (CK) (Po0.015), as well as higher levels of proteins (Po0.001), creatinine (P ¼ 0.001) and urea (P ¼ 0.001) in workers compared with controls, along with significantly higher uric acid levels (P ¼ 0.012). Furthermore, the number of years exposed to pesticides predicted higher activities of alanine aminotransferase, CK, ALP, as well as uric acid levels. Overall, chronic exposure to pesticides appeared to affect several biochemical parameters. These biomarkers seem to be indicative of adverse effects of pesticides in agricultural workers, confirming their use for routine monitoring of effects.

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Biochemical effects of some pesticides on lipid peroxidation and free-radical scavengers

Cited by 483 publications

References 23 publications

Dose-Dependent Hematological, Hepatic and Gonadal Toxicity of Cypermethrin in Wistar Rats

Dose-Dependent Hematological, Hepatic and Gonadal Toxicity of Cypermethrin in Wistar Rats

Lambda Cyhalothrin Elicited Dose Response Toxicity on Haematological, Hepatic, Gonadal and Lipid Metabolic Biomarkers in Rat and Possible Modulatory Role of Taurine

Adverse effects of pesticides on biochemical and haematological parameters in Tunisian agricultural workers

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