Biochemical Concomitants of the Storage of Behavioral Information

Protein synthesis and memory: A review.

“…These results markedly contrast with those of studies where mice are treated with ANI, AXM, or CYC and where species other than mice are treated with PURO. Specifically, (a) PSIs other than PURO do not affect memory when given hours or longer after training (Barraco & Stettner, 1976 and references therein), (b) unlike mice, goldfish (Agranoff, 1968(Agranoff, , 1969(Agranoff, , 1970(Agranoff, , 1971(Agranoff, , 1972(Agranoff, , 1974(Agranoff, , 1980(Agranoff, , 1981Agtanoff, Burrell, Dokas, & Springer, 1978;Agranoff, Davis, & Brink, 1965Agranoff & Klinger, 1964; R. E. Springer & Agranoff, 1976a, 1976bSpringer, Schoel, Klinger, & Agranoff, 1975), pigeons (Stettner et al, 1977(Stettner et al, , 1979, and quail (Mayor, 1969) demonstrate normal retention of new learning when intracerebrally injected with PURO 24 hr or more after training, and (c) whereas behavioral performance of animals injected with either ANI, CYC, or AXM hours after training is unaffected, pigeons treated with PURO 24 hr after initial training fail to improve as rapidly as saline-injected animals during subsequent training sessions (Stettner et al, 1979).…”

The past, the future and the biology of memory storage

“…In the 1960s, Louis Flexner and his colleagues ¢rst found that short-and long-term memory are not only distinguished by their time-course but also by their biochemical mechanism. Long-term memory di¡ers from short-term memory in requiring the synthesis of new protein (Flexner et al 1965;Agrano¡ 1976). This requirement for protein synthesis for long-term memory has a speci¢c time-window, during and shortly after training, which is called the consolidation phase.…”