Biochemical changes in some trace elements, antioxidant vitamins and their therapeutic importance in prostate cancer patients

Onyema-iloh, Bridget Obiageli; Meludu, SC; Iloh, E. O.; Johnkennedy, Nnodim; Onyegbule, Onyema A.; Myke-Mbata, Blessing

doi:10.3126/ajms.v6i1.10799

Cited by 6 publications

(15 citation statements)

References 11 publications

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“…Evidence suggests that environmental factors acting in concert with genetic influences could be responsible for PCa severity which usually determines the disease progression [89101112]. Low zinc status is one environmental factor that has been implicated to play a role in prostate carcinogenesis and its severe variants which define the disease progression [1112].…”

Section: Introductionmentioning

confidence: 99%

The impact of plasma zinc status on the severity of prostate cancer disease

2019

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Purpose The severity of prostate cancer (PCa), which determines the disease progression, is theorized to be a function of zinc status. Hence, this study was structured to determine the impact of zinc status on the severity and progression of PCa disease. Materials and Methods This was a descriptive cross-sectional study of 220 histologically-confirmed PCa patients and 220 age-matched controls, conducted prospectively in a Nigerian tertiary hospital. Plasma zinc, prostate-specific antigen, creatinine, fasting glucose, and estimated glomerular filtration rate were determined for both study groups. The International Society of Urological Pathology (ISUP) grades and the American Joint Committee on Cancer clinical staging were employed as indices for PCa severity (grade) and progression (stage) respectively. Results The PCa patients had markedly reduced plasma zinc status compared to controls (cases: 9.42±3.02 µmol/L versus controls: 15.23±4.47 µmol/L; p<0.001). Low zinc status was more pronounced within the severe grade and advanced PCa disease subgroups (p<0.001). Inverse relationships existed between zinc status and ISUP grades among the entire PCa patient (p<0.001) and the categorized PCa grade and stage subgroups (p<0.001). Low zinc status had significant impact of predicting severe (crude=odds ratio [OR], 8.714; p<0.001; age-adjusted=OR, 11.152; p<0.001) and advanced (crude=OR, 17.160; p<0.001; age-adjusted=OR, 18.927; p<0.001) PCa disease. Conclusions This study suggests that low plasma zinc status is associated with severe grade and advanced PCa disease. However, further well-designed studies with large sample sizes are warranted to confirm these associations.

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Section: Introductionmentioning

confidence: 99%

The impact of plasma zinc status on the severity of prostate cancer disease

2019

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“…This finding contradicts other studies on the association of trace elements and some vitamins with prostate disorders. 2,3,[14][15][16] On the other hand, a significant increase in the serum level of Vit A was observed in the prostatic cancer group compared to the control with other vitamins and trace elements showing no significant difference which negates the reports of other previous similar studies. 3 Furthermore, PSA is observed to be positively correlated with trace elements and vitamins in the control subjects.…”

Section: Discussionmentioning

confidence: 89%

“…2,3,[14][15][16] On the other hand, a significant increase in the serum level of Vit A was observed in the prostatic cancer group compared to the control with other vitamins and trace elements showing no significant difference which negates the reports of other previous similar studies. 3 Furthermore, PSA is observed to be positively correlated with trace elements and vitamins in the control subjects. Vitamin A, its natural and synthetic analogs have been reported to enhance prostate cancer risks and it is remarkable that the BPH group investigated in this study showed positive correlation of PSA with vitamin A.…”

Section: Discussionmentioning

confidence: 89%

“…11 However, our result shows that there is no difference in the serum levels of most of the trace elements (copper, selenium) and antioxidant vitamin namely Vit E between subjects with prostate disorder and the control group, however, only iron and Vit A has shown an increased levels in the prostate cancer group, suggesting that cancer of the prostate alters the serum concentration of these analytes. Contrarily, Onyema-iloh et al 3 has reported significantly reduced serum levels of selenium, zinc, vitamin E and C, and higher levels of copper, when compared to the apparently healthy control group. Some trace elements have been reported of playing a major role in the biology of cancer; however, there is still a gap in our understanding of the relationship between the function of trace elements and the initiation, advancement and inhibition of carcinogenic process of the prostate gland.…”

Section: Discussionmentioning

confidence: 94%

“…2 Therefore, evaluating these trace elements and antioxidant vitamins could be useful in preventing some adverse clinical conditions and complications that can result in death due to the insufficiency or excess availability of these biochemical analytes in prostate complications. 3 The prostate contains some smooth muscles that help in expelling seminal fluid during ejaculation. This relatively alkaline, milky fluid secreted by the prostate nourishes and protects the sperm.…”

Section: Introductionmentioning

confidence: 99%

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Serum Trace Elements and Antioxidant Vitamins among Male Patients with Prostate Disorders in the Delta Region of Nigeria

Aghawegbehe¹,

Atere

Akinbo

et al. 2019

amj

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Background: Prostate cancer remains the commonest form of cancer among Nigerian males, constituting 13.3% of all male cancers encountered in this region. Trace elements and antioxidant vitamins may be of epidemiological significance in the early prediction and treatment of prostate complications. The study aimed to explore the serum trace elements, antioxidant vitamins concentration and serum prostate specific antigen (PSA) among male with prostate disorders in the delta region of Nigeria. Methods: Blood specimens were collected from males with symptoms of prostatitis (n=70), benign prostatic hyperplasia (BPH; n=60) and prostate cancer (PCa; n=70), alongside with apparently healthy male subjects (n=60). The levels of trace elements and antioxidant vitamins were evaluated. Fluorescence immunoassay technique was used to assess the expression of PSA. Results: Compared with the controls, PCa patients had a significantly increased level of vitamin A (p<0.05), however, no significant differences in the serum levels of trace elements and antioxidant vitamins between subjects with prostate disorders and control group (p>0.05). Interestingly, there was a significant positive correlation between prostate specific antigen, trace elements and vitamins in BPH group (p<0.05). Conclusions: Prostate disorders such as prostatitis, BPH and PCa may be associated with elevated levels of PSA, but, does not affect the circulating expression of some serum trace elements and antioxidant vitamins.

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