Biochemical Changes in Lethal Staphylococcal Infections in Mice

Counts, George W.; Smith, Ian M.; Routh, Joseph I.; Hazard, Elia Ch.; McTavish, Jennifer

doi:10.1038/191783a0

Cited by 19 publications

(3 citation statements)

References 8 publications

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“…Berry and Smythe (3) found that a diminution in muscle and liver glycogens in mice injected with Salmonella typhimurium was attributable to bacterial toxins. Although Staphylococci are known to excrete a variety of toxic substances, similar hypoglycemia and a marked depletion of hepatic glycogen were seen during lethal staphylococcal infections of mice (7,20,21).…”

Section: Discussionmentioning

confidence: 94%

“…Although many workers have been studying biochemical disorders in animals experimentally infected with a pathogenic microorganism such as Salmonella typhimurium (3), Staphylococus aureus (7,20,21), Listeria monocytogenes (23,49,50), and Mycobacterium tuberculosis (19,34,35), Coxiella burnetti (30), little precise information has been given concerning the alteration in lipid metabolism in animals (1). However, recently, Groves et al (16) and Griffith et al (17) found an increase in the level of serum triglyceride in dogs with gram-negative bacteremia.…”

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confidence: 99%

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Metabolie Aspects in Mice Administered Live Salmonella typhimurium

Sakaguchi

Hsu

Sakaguchi

1980

Microbiology and Immunology

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The influence of intraperitoneal inoculation of live Salmonella typhimurium on carbohydrate and lipid metabolisms in mice was investigated at doses of 9.2 × 107 cells, 1.9 × 108 cells, and 3.8 × 108 cells. The hepatic glycogen content in mice at 18 hr after the inoculation decreased in inverse proportion to an increase in the injection dose. The activities of hepatic phosphorylase and G‐6‐Pase increased significantly after 2 hr, but after 18 hr the levels of both enzyme activities, especially G‐6‐Pase, declined in inverse porportion to an increase in dose of viable cells administered to the mice. The levels of serum glucose and free fatty acids (FFA) in mice markedly decreased at doses of 1.9 × 108 and 3.8 × 108 cells after a transient rise at early stage (1 hr) after the injection. Marked hypertriglyceridemia was seen in infected mice. However, the activity in serum lipoprotein lipase (LPL) was reduced by an increase in the injection dose. The effect of intraperitoneal administration of viable cells on the serum triglyceride level was prevented in mice immunized with S. typhimurium endotoxin or administered with the anti‐endotoxin serum. These results indicate that hypertriglyceridemia mainly results from the action of endotoxin in the pathogen. Serum lactate dehydrogenase (LDH) activity markedly increased at the dose of 3.8 × 108 cells within 8–16 hr, and the infected mice exhibited a leakage of isozymes LDH‐3 and 5 in the serum 16 hr post‐inoculation.

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Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

Metabolie Aspects in Mice Administered Live Salmonella typhimurium

Sakaguchi

Hsu

Sakaguchi

1980

Microbiology and Immunology

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“…Biochemical analysis of the bruised tissue injected with S. aureus (MS) for acid phosphatase, deoxyribonuclease, and ribonuclease did not show any increase in activity above that encountered because of bruising alone (Brown, 1964). Counts et al (1961) and Lindell et al (1963) reported that staphylococcus infections in mice affected many biochemical activities in their blood. These authors found that mice killed by infection of virulent staphylococcus showed a high blood concentration of transaminase, alkaline and acid phosphatase, and inorganic phosphate associated with a low sodium.…”

Section: Resultsmentioning

confidence: 99%

Fate of Staphylococcus aureus in Bruised Tissue12

Hamdy¹,

Barton²

1965

Applied Microbiology

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HAMDY, M. K. (University of Georgia, Athens), AND N. D. BARTON. Fate of Staphylococcus aureus in bruised tissue. Appl. Microbiol. 13:15-21. 1965.-This investigation was initiated to determine the fate and behavior of a virulent marker strain of Staphylococcus aureus (MS) injected intramuscularly into both control and traumatized tissues. Control tissues appeared to possess a clearing mechanism highly active against this organism, whereas bruised tissues stimulated and supported its growth. This stimulation may be due to the presence of extrastromal hemoglobin in the bruised areas. By use of the disc-sensitivity procedure, extrastromal hemoglobin was found to enhance the growth of S. aureus (MS) and this stimulation was linearly dependent on concentration in the range of 0.002 to 0.008 ,mole per disc. Physical and physiological factors affecting the fate of staphylococci in poultry tissues were studied. The results showed that the number of viable cells of S. aureus (MS) in the initial inoculum exerted little effect on the survival activity patterns of this organism in the traumatized tissues. Control tissues, however, only became infected when a suspension containing 1.34 X 109 cells of the marker strain was injected. Regardless of the concentration of cells of this test culture inoculated into bruised areas, the staphylococci did not increase in number above a log of 8.5 organisms per gram of tissue. The extent of both tissue damage and accumulation of blood and fluid seemed to play an important role in the fate of staphylococci in experimentally induced infection. A correlation was noted between the severity of the bruise and the rate of growth and multiplication of virulent staphylococci in the tissue. The rate of growth showed a 100-fold increase in 1 day in the severe bruise, in 2 days in the medium bruise, and in 3 days in the superficial bruise. Time-course studies revealed that virulent S. aureus (MS) was able to persist in bruised tissue for long periods of time (18 days) even in the absence of noticeable infection. Therefore, it is believed that bruised tissue is a source of contamination to other birds and a health hazard to man.

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Liver Metabolism and Energy Production in Staphylococcus aureus Septic Shock in Mice

Smith

Mukherjee

1972

Advances in Experimental Medicine and Biology

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Biochemical Changes in Lethal Staphylococcal Infections in Mice

Cited by 19 publications

References 8 publications

Metabolie Aspects in Mice Administered Live Salmonella typhimurium

Metabolie Aspects in Mice Administered Live Salmonella typhimurium

Fate of Staphylococcus aureus in Bruised Tissue12

Liver Metabolism and Energy Production in Staphylococcus aureus Septic Shock in Mice

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