2009
DOI: 10.1590/s1678-91992009000100008
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Biochemical and pharmacological study of venom of the wolf spider Lycosa singoriensis

Abstract: ABSTRACT:The wolf spider Lycosa singoriensis is a large and venomous spider distributed throughout northwestern China. Like other spider venoms, the wolf spider venom is a chemical cocktail. Its protein content is 0.659 mg protein/mg crude venom as determined by the Lowry method. MALDI-TOF analysis revealed that the venom peptides are highly diverse and may be divided into three groups characterized by three independent molecular ranges: 2,000 to 2,500 Da, 4,800 to 5,500 Da and 7,000 to 8,000 Da, respectively.… Show more

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Cited by 17 publications
(11 citation statements)
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“…These results consistent with that of Ahmed et al (2012) which found that scorpion Heterometrus xanopus has antibacterial effect on B. subtillis with inhibition zone of 30 mm, while, Escherichia coli showed resistance against the same venom. This study was compatible with Liu et al (2009) study on wolf spider Lycosa singoriensis which was effective only on B. subtillis under very low concentration (3 mg/ml) and has weak effect on C. albicans fungus. Interestingly, Buthus martensii venom was detected only against Grampositive bacteria but not against Gram-negative one (Gao et al, 2007).…”
Section: Discussionsupporting
confidence: 84%
See 1 more Smart Citation
“…These results consistent with that of Ahmed et al (2012) which found that scorpion Heterometrus xanopus has antibacterial effect on B. subtillis with inhibition zone of 30 mm, while, Escherichia coli showed resistance against the same venom. This study was compatible with Liu et al (2009) study on wolf spider Lycosa singoriensis which was effective only on B. subtillis under very low concentration (3 mg/ml) and has weak effect on C. albicans fungus. Interestingly, Buthus martensii venom was detected only against Grampositive bacteria but not against Gram-negative one (Gao et al, 2007).…”
Section: Discussionsupporting
confidence: 84%
“…Valavi and Alemzadeh-Ansari (2008), reported that Hemiscorpius lepturus scorpion has hemolytic activities. Also, crude venom of wolf spider Lycosa singoriensis has hemolytic effect on human erythrocytes in a dose-dependent manner (Liu et al, 2009). On the other hand, some toxins in both scorpion venom as hadrurin and in centipedes as scolopendrin I showed hemolysis activity at different concentrations, and it reached 75% hemolysis under the effect of hadrurin from scorpion (Wenhua et al, 2006).…”
Section: Discussionmentioning
confidence: 99%
“…In conclusion, 2DE evidently acts as the better tool in profiling proteins found in a complex mixture such as those of snake venoms in comparison to SDS-PAGE, though the latter remains vital as a rapid and inexpensive investigating technique (30). Two-dimensional gel electrophoresis, due to its additional parameter of separation is more suitable for detecting minute differences between closely related samples.…”
Section: Discussionmentioning
confidence: 99%
“…These peptides display an amphipathic a-helix, typical of many very active AMPs, and show activity against Gram-negative bacteria (Escherichia coli) and yeast (Candida glabrata). AMPs from L. singoriensis venom (Xu et al 1989;Budnik et al 2004;Liu et al 2009) with molecular masses in the range of 2,000-3,000 Da have also been isolated.…”
Section: Introductionmentioning
confidence: 99%