Biochemical and morphological changes in <i>Trypanosoma brucei brucei-</i> infected rats treated with homidium chloride and diminazene aceturate

Adeyemi, Oluyomi Stephen; Sulaiman, Faoziyat Adenike

doi:10.1515/jbcpp-2012-0018

Cited by 39 publications

(31 citation statements)

References 6 publications

(11 reference statements)

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“…The decreased levels of GSH after exposure to AgNPs may be due to complexing of AgNPs with thiol groups or to increasing use of GSH to downplay the effect of free radicals after exposure to the nanoparticles. 52,53 These nanoparticles have a strong affinity for thiol groups and may therefore predispose to a decrease in GSH content, thereby leading to the formation of complexes between radical species and cellular proteins or other biomolecules. Se is an essential element with beneficial antioxidant property and is a structural component of several enzymes like GSH-Px and Trx reductase, and has been found to have detoxification effects on various heavy metals.…”

Section: Discussionmentioning

confidence: 99%

Antioxidant and hepatoprotective role of selenium against silver nanoparticles

Ansar

Alshehri

Abudawood

et al. 2017

IJN

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Silver nanoparticles (AgNPs) have attracted the most interest in terms of their potential biomedical and industrial applications. However, these nanoparticles have shown their toxic behavior toward environment, living tissues, and organisms. Selenium (Se), an essential trace element, is necessary for various metabolic processes, including protection against oxidative stress and immune function. The present study was undertaken to evaluate the effect of Se against AgNP-induced hepatic oxidative stress. AgNPs were synthesized and then prepared nanoparticles were characterized using various analytical techniques such as UV-visible spectroscopy, X-ray diffraction, and transmission electron microscopy. Rats were administered AgNPs intraperitoneally (5 mg/kg/day) and Se (0.2 mg/kg) was given by gavage. AgNP administration induced hepatic damage as indicated by the serum marker enzymes with reduction in levels of glutathione, and decrease in activities of SOD, CAT, and GSH-peroxidase ( P <0.05). Decrease in levels of total antioxidant capacity (TAC) and increase in level of C-reactive protein (CRP) was also observed in AgNP-treated group compared to control group. However, Se markedly attenuated AgNP-induced biochemical alterations, levels of TAC, CRP, and serum transaminases (AST, ALT) ( P <0.05). Taken together, these findings suggest that administration of AgNPs produces hepatotoxicity in rats, whereas Se supplementation attenuates these effects.

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Section: Discussionmentioning

confidence: 99%

Antioxidant and hepatoprotective role of selenium against silver nanoparticles

Ansar

Alshehri

Abudawood

et al. 2017

IJN

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“…The elevation of ALT level in rat serum and tissues may be the result of adaptive mechanism by the animals in order to offset the stress imposed by the nanoparticle administration. Living cells have been reported to increase the de novo synthesis of proteins in response to stressors such as drugs or chemical agents (Adeyemi and Sulaiman, 2012). The elevation of ALT activity may also be an early indicator for hepatotoxicity consequent upon exposure to nanoparticles.…”

Section: Discussionmentioning

confidence: 99%

Oral Exposure to Silver/Gold Nanoparticles: Status of Rat Lipid Profile, Serum Metabolites and Tissue Morphology

Sulaiman¹,

Akanji²,

Oloyede³

et al. 2015

J. of Medical Sciences

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Study investigated the effect of oral administration of gold-silver nanoparticles on rat biochemical parameters and tissue morphology. Wistar rats weighing approximately 180±7 g were randomly assigned into four groups. Animals in the control group received distilled water once daily for 30 days while, those in the treatment groups were administered 10, 50 and 100 mg kgG 1 b.wt. gold-silver nanoparticles. The rats were sacrificed under slight anesthesia, 24 h after the last treatments. Blood and vital organs including the heart, kidney and liver were collected and prepared for biochemical and histopathological determinations. Exposure to Ag/Au nanoparticles altered the rat serum lipid profile; lowering the HDL-C while raising the atherogenic index. Exposure of Ag/Au nanoparticles in rats caused significant alteration to the levels of serum albumin, total protein, bilirubin, urea and creatinine. The activities of alanine transaminase, aspartate transaminase and alkaline phosphatase in rat serum and tissues were also significantly altered by Ag/Au nanoparticles exposure. The histopathological examination revealed inflammation and cellular degeneration caused by exposure to the Ag/Au nanoparticles. We show evidence that Ag/Au nanoparticles elevated atherogenic index, as well as caused biochemical and morphological alterations, reminiscent of cellular injury.

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“…GSH is an antioxidant that can quench free radicals or serve as a substrate for other antioxidant enzymes, such as Glutathione Peroxidase and Glutathione Reductase (↓GSH). The decreased levels of ↓GSH after exposure to silver nano particles may be due to complexing of silver nano particles with Thiol groups leads to production of ROS and oxidative stress [22,23] or increase use of ↓GSH downplay the effect of free radicals after exposure to silver nano particles [24]. These nano particles have a strong affinity for thiol groups [22] and may therefore predispose to a decrease in ↓GSH content, there by leading to the formation of complexes between radical species and cellular proteins or other biomolecular structure.…”

Section: Discussionmentioning

confidence: 99%

Particle Size Dependent Teratogenicity of Silver Nanoparticles in Mice

Prakash

Singh

Pratap

et al. 2016

MOJAP

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Nanoparticles because of their unique properties have widespread application in biomedicine and many industrial sectors. The present study was undertaken to determine the potential effects of AgNPs of different size on pregnant dams and fetal development after maternal exposure on gestational days (GD) 6-19 in mice. AgNPs, of 20nm and 1300 nm respectively were administered to pregnant mice by oral gavages at concentrations of 0.5 mg/kg/day and 1 mg/kg/day. All dams were subjected to Cesarean section on GD 20. The fetuses were evaluated for signs of embryotoxic and teratogenic effects. AgNPs caused a decrease in Catalase and Reduced Glutathione activities at ≥ 0. 5 mg/kg/day and a reduction in glutathione content at 1 mg/kg/day in maternal liver tissues. However, no treatment-related deaths or clinical signs were observed in any of the animals treated with AgNPs. Fetal liver tissue showed significant decrease in Catalase and Reduced Glutathione activities. Histomorphological alterations in the fetal liver were observed at 1300nm particle group which were exacerbated in 20 nm group. The results show that a repeated oral dose of AgNPs during pregnancy caused oxidative stress in fetal hepatic tissue which is not only dose dependent but also depends on the particle size.

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Biochemical and morphological changes in Trypanosoma brucei brucei- infected rats treated with homidium chloride and diminazene aceturate

Cited by 39 publications

References 6 publications

Antioxidant and hepatoprotective role of selenium against silver nanoparticles

Antioxidant and hepatoprotective role of selenium against silver nanoparticles

Oral Exposure to Silver/Gold Nanoparticles: Status of Rat Lipid Profile, Serum Metabolites and Tissue Morphology

Particle Size Dependent Teratogenicity of Silver Nanoparticles in Mice

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