Bioceramic composites for orthopaedic applications: A comprehensive review of mechanical, biological, and microstructural properties

Shekhawat, Deepika; Singh, Amit Kumar; Banerjee, M. K.; Singh, Tej; Patnaik, Amar

doi:10.1016/j.ceramint.2020.09.214

Cited by 94 publications

(46 citation statements)

References 169 publications

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“…The main required properties of orthopedic biomaterials are good mechanical abilities including high resistance to corrosion and wear, biocompatibility, chemical stability and appropriate microstructural characteristics ( Fig. 1 ) ( 7 , 8 ). A high longevity of materials expressed by unaltered properties after a long time of contact with the biological surroundings are tremendously essential.…”

Section: Biomaterials In Orthopedicsmentioning

confidence: 99%

“…The coating of metals with bioactive ceramics and the chemical modification of metal surface by binding of polymers and biomolecules allow the biofunctionalization of metallic materials and the control of the biodegradability rate and biocompatibility ( 8 , 12 ). In this regard, magnesium alloys (Mg-Ca, Mg-Zn) and magnesium matrix composites (Mg-calcium phosphate particle, Mg-hydroxyapatite, Mg-tricalcium phosphate) are one of the metallic materials which have recently attracted growing interest due to their improved mechanical and biological properties ( 9 , 13 ).…”

Section: Biomaterials In Orthopedicsmentioning

confidence: 99%

“…Due to their superior mechanical properties, metals have been mostly used in prostheses stems, fracture plates, or as load-bearing components in total joint replacement. The most commonly used metals include stainless steels (316L), titanium and titanium-base alloys (Ti-6Al-4V, TiAl4VELI, Ti6Al17Nb) and cobalt alloys (Co-Cr-Mo) (Table I) (7)(8)(9). Among these, titanium and its alloys show an excellent corrosion resistance and a high biocompatibility as well as good long-term behavior (10).…”

Section: Biomaterials In Orthopedicsmentioning

confidence: 99%

“…The main advantages of these materials are high corrosion resistance, hardness, wear resistance, low friction, significant biocompatibility and osseointegration with the host tissue. On the basis of tissue-material interface reaction, bioceramics are generally classified into three categories: i) bioactive (hydroxyapatite, bioactive glasses); ii) bioresorbable (calcium phosphate) and iii) bioinert (alumina, zirconia) (Table I) (8,9,(17)(18)(19)(20). It is of interest to modulate the chemistry of ceramics that they become osteoinductive but also to enhance the bone regeneration rate.…”

Section: Biomaterials In Orthopedicsmentioning

confidence: 99%

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Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review)

et al. 2021

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Biocompatibility is one of the mandatory requirements for the clinical use of biomaterials in orthopedics. It refers to the ability of a biomaterial to perform its function without eliciting toxic or injurious effects on biological systems but producing an appropriate host response in a specific case. Today, the biocompatibility concept includes not only bio-inertia, but also biofunctionality and biostability. High biocompatibility and functional properties are highly desirable for new biomaterials. The chemical, mechanical, structural properties of biomaterials, their interaction with biological environment or even the methodology of assessment can influence the biocompatibility. The biological evaluation of biomaterials includes a broad spectrum of in vitro and in vivo tests related to the cytocompatibility, genotoxicity, sensitization, irritation, acute and chronic toxicity, hemocompatibility, reproductive and developmental toxicitity, carcinogenicity, implantation and degradation as specified in different international standards. A brief review of the main assays used in the biocompatibility testing of orthopedic biomaterials is presented. In addition, their main biocompatibility issues are overviewed.

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Section: Biomaterials In Orthopedicsmentioning

confidence: 99%

Section: Biomaterials In Orthopedicsmentioning

confidence: 99%

Section: Biomaterials In Orthopedicsmentioning

confidence: 99%

Section: Biomaterials In Orthopedicsmentioning

confidence: 99%

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Biocompatibility assessment of biomaterials used in orthopedic devices: An overview (Review)

et al. 2021

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“…Ceramic materials are used as implant biomaterials because they have the same bone mineral components, biocompatibility, and osseointegration with human tissue. Bioceramics are ceramic materials commonly used in the manufacture of implants and orthopedic application devices which function to repair and replace diseased and injured parts in the human body [4].…”

Section: Introductionmentioning

confidence: 99%

Biocompatibility Test of Ceramic Materials in Zebrafish Development

Dani¹,

Ana²,

Retnoaji³

2021

Proceedings of the 6th Asia-Pacific Education and Science Conference, AECon 2020, 19-20 December 2020, Purwokerto, Indonesia

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The use of dental implants, which be implanted directly into bone is one of the major advances in modern dentistry. One of the dental implants that have recently been proposed is bio-ceramic. One of the prerequisites for the use of bioceramic is biocompatibility, which means being able to interact and connect with living tissue and the physiological environment without causes any adverse effect on the tissue. Zebrafish (Danio rerio) are known as model organisms that have similarities with humans such as the composition of bones, bone cells, and molecular signaling. The purpose of this study was to determine the effect of various bio-ceramic concentrations exposure to the structure of zebrafish bone tissue. The research was conducted in the laboratory of animal structure and development, Faculty of Biology, Gadjah Mada University. Fertilized zebrafish embryos were chosen and exposed to specific concertation of a ceramic material solution on the well plate, as follows 250µg, 500µg, and 750µg for a period of 72 hpf. One-way ANOVA test was used to assess the significance (P<0,05) of the control treatment results and various bio-ceramic concentrations. The results showed no effect of bio-ceramics (CHA-Ag) on survival rate, hatching rate, and heartbeat rate per minute at all exposures. However, some embryos and larvae at the age of 24-72 hpf concentration of bio-ceramics exposure 750μg, indicating were morphological changes such as egg yolk deformation, malformations of the spine, tail, and caudal fin, and stunted body or eye growth.

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