Biocatalytic Metal‐Organic Frameworks: Promising Materials for Biosensing

Abstract

The highly efficient and specific catalysis of enzymes allows them to recognize a myriad of substrates, which enables biosensing. However, the fragility of natural enzymes severely restricts their practical applications. Metal-organic frameworks (MOFs) with porous networks and attractive functions have been intelligently employed as supports to encase enzymes and protect them against harsh environments. More importantly, customizable construction and composition affords the intrinsic enzyme-like activity of some MOFs (known as nanozymes), which provides an alternative route for the construction of robust enzyme mimics. This review will introduce the concept of these biocatalytic MOFs, with special emphasis on how biocatalytic processes that operate in these materials can reverse the plight of native enzyme-based biosensing. In addition, the present challenges and future outlooks in this research field are briefly discussed.

A Non-enzymatic Electrochemical Sensor of Cu@Co-MOF Composite for Glucose Detection with High Sensitivity and Selectivity

“…A cobalt metal-organic framework (Co-MOF), [Co3(BDC)3(DMU)2], was prepared via an ionothermal reaction, which features three 1D chains along the [110], [011] and b-directions. The chains along the [110] and b-directions interconnect into a 2D [4,4] topological network, and finally shape a 2,6-connected {8 12 .12 3 }{8}3 network by the connection of the [011] chains with the 2D layers. Co-MOF was further synthesized into a Cu@Co-MOF composite material through a sequential deposition-reduction process.…”

“…The data can be obtained free from CCDC via www.ccdc.cam.ac.uk/data_request/cif. 12 .12 3 }. Therefore, the 3D framework is topologized as a 2,6-connected {8 12 .12 3 }{8}3 network.…”

“…12 .12 3 }. Therefore, the 3D framework is topologized as a 2,6-connected {8 12 .12 3 }{8}3 network.…”

“…Non-enzymatic Glu sensors have much more choices in material platforms to achieve larger surface area rather than the stacking of enzymes. For example, metal-organic frameworks (MOFs) are a kind of porous materials constructed by the self-assembly of metal ions with organic ligands into highly ordered structures [12,13]. Their poor conductivity blocks raw MOFs as Glu sensing electrocatalysts.…”

Confining enzymes in porous organic frameworks: from synthetic strategy and characterization to healthcare applications

“…Considering the convenient de novo procedure for the encapsulation of enzymes in ZIFs, an increasing number of ZIF-8-, ZIF-67- and ZIF-90-confined biocascade systems has been readily constructed, displaying desirable cascade activities and enhanced stability owing to the protection from the ZIF shells. 86–88…”