Bioavailable nanoparticles obtained in laser ablation of a selenium target in water

Kuzmin, P. G.; Shafeev, G. A.; Voronov, V. V.; Raspopov, R. V.; Arianova, E A; Трушина, Э Н; Gmoshinskiĭ, I V; Хотимченко, С А

doi:10.1070/qe2012v042n11abeh014754

Cited by 33 publications

(19 citation statements)

References 3 publications

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“…Each of these phases is the result of specific synthesis conditions and, therefore, can be used to determine the mechanism through which the nanoparticles have been generated. The synthesis of Se NPs by PLAL using nanosecond lasers has already been reported and characterized by different groups (27–31). The primary mechanism of nanoparticle generation in those studies is melting.…”

Section: Methodsmentioning

confidence: 99%

Inhibition of Candida albicans biofilm by pure selenium nanoparticles synthesized by pulsed laser ablation in liquids

Guisbiers

Lara

Mendoza‐Cruz

et al. 2017

Nanomedicine: Nanotechnology, Biology and Medicine

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Selenoproteins play an important role in the human body by accomplishing essential biological functions like oxido-reductions, antioxidant defense, thyroid hormone metabolism and immune response; therefore, the possibility to synthesize selenium nanoparticles free of any contaminants is exciting for future nano-medical applications. This paper reports the first synthesis of selenium nanoparticles by femtosecond pulsed laser ablation in de-ionized water. Those pure nanoparticles have been successfully used to inhibit the formation of Candida albicans biofilms. Advanced electron microscopy images showed that selenium nanoparticles easily adhere on the biofilm, then penetrate into the pathogen, and consequently damage the cell structure by substituting with sulfur. 50% inhibition of Candida albicans biofilm was obtained at only 25 ppm. Finally, the two physical parameters proved to affect strongly the viability of Candida albicans are the crystallinity and particle size.

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Section: Methodsmentioning

confidence: 99%

Inhibition of Candida albicans biofilm by pure selenium nanoparticles synthesized by pulsed laser ablation in liquids

Guisbiers

Lara

Mendoza‐Cruz

et al. 2017

Nanomedicine: Nanotechnology, Biology and Medicine

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“…Recent studies demonstrated the positive impact of selenium nanoparticles (SeNPs) on different organ systems. SeNPs appeared to have antioxidant, antimicrobial, anti-carcinogenic properties [7][8][9] characterized by good permeability in tissues [9,10] SeNPs show better biocompatibility, bioefficacy, and lower toxicity compared with inorganic and organic selenocompounds [11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Effect of High Dose of Selenium Nanoparticles on Alimentary Tract in Rodents

Khubulava¹,

Chichiveishvili²,

Shavshishvili³

et al. 2019

J Nanomed Nanotechnol

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“…Selenium deficiency decreases the protective ability of the body to free radicals. [20][21][22][23][24][25][26][27][28][29][30] According to the conducted studies, the amount of selenium and GPx is less in people with diabetes mellitus in comparison with healthy ones. It was found that an amount of Selenium and GPx decreases during the progression of diabetes.…”

Section: Introductionmentioning

confidence: 99%

“…It was found that an amount of Selenium and GPx decreases during the progression of diabetes. [13][14][15][16][17][18][19][20][21][22] GPx deficiency could have a key role in the pathogenesis of diabetes mellitus due to increased oxidative stress. Increased production of free radicals and reduction of antioxidant activity the person affected with diabetes mellitus requires administration of a relatively large number of antioxidants in comparison with healthy one.…”

Section: Introductionmentioning

confidence: 99%

Untitled

Khubulava¹

2018

AJP

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Aim: Nanotechnology and nanomedicine revolutionized the pharmaceutical market, medicine, and biology. The simple size comparison gives an idea of using nanoparticle as very small probes that would allow us to observe the cellular machinery without introducing too much interference. "Nanosizing" drugs decrease toxicity and reduces the needed dose. Nanoparticles are used for site-specific drug delivery, imaging, treating illnesses, and diseases such as cancer, neurodegenerative disorders, ocular diseases, respiratory diseases, and diabetes mellitus. Recent studies indicate the positive impact of selenium nanoparticles on different organ systems. They have antioxidant, antimicrobial, anti-carcinogenic properties, and selenium nanoparticles characterized by good permeability in tissues and low toxicity. Nowadays, there are different ways of preparing nanoparticles, but most of them are related to difficult, toxic, and expensive procedures. Materials and Methods: Pure selenium metal powder was used and synthesized nanoparticles were characterized by JEOL JSM-6510 LV scanning electron microscope (SEM), Zeiss Ultra 55 SEM, and JOEL JEM-100SX transmission electron microscope; also by dynamic light scattering (Thermo Scientific Nicolet iS50 -Fourier-transform infrared spectroscopy [FTIR]) and Malvern Instruments Zeta Sizer Nano ZS. To reduce the size of the selenium powder, we used planetary ball mill DECO-PBM-V-0.4L and Ultrasonic Homogenizer UZDN-1 U4.2. Results and Discussion: Pure selenium grinded powder was characterized in JEOL JSM-6510 LV SEM and wet grinded in Deco planetary ball mill further size reduction to 2-10 µm was confirmed by SEM. Selenium powder suspension was irradiated using ultrasonic homogenizer and characterized for intensity and size of nanoparticles with dynamic light scattering FTIR. Average Zeta potential of -35.05 mV has been recorded. Toxic dose of 5000 mg/kg of selenium nanoparticles has been established as per accordance to OECD guidelines. Conclusion: Safe, simple, and cost-effective SeNPs have been developed for the effective treatment of disease such as diabetes with opening of new prospective further in nanotechnology and nanosized drug delivery system.

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Bioavailable nanoparticles obtained in laser ablation of a selenium target in water

Cited by 33 publications

References 3 publications

Inhibition of Candida albicans biofilm by pure selenium nanoparticles synthesized by pulsed laser ablation in liquids

Inhibition of Candida albicans biofilm by pure selenium nanoparticles synthesized by pulsed laser ablation in liquids

Effect of High Dose of Selenium Nanoparticles on Alimentary Tract in Rodents

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