Bioavailability of the sodium pertechnetate and morphometry of organs isolated from rats: study of possible pharmacokinetic interactions of a ginkgo biloba extract

Abstract

Many compounds affect the bioavailability of radiobiocomplexes as radiopharmaceuticals. Ginkgo Biloba extract (EGb) has several effects. The influence of an EGb on the bioavailability of the radiobiocomplex sodium pertechnetate (Na99mTcO4) and on the morphometry of the organs was evaluated. Rats were treated with EGb and Na99mTcO4 was injected. The animals were sacrificed; the radioactivity in the organs was counted. The results showed that EGb altered the Na99mTcO4 bioavailability in the kidneys, liver and duodenum. Morphometric analysis of the organs showed significant alterations (P<0.05), probably caused by metabolites generated by EGb and capable of altering the bioavailability of the Na99mTcO4.<br>Substâncias podem interferir na biodisponibilidade de radiobiocomplexos, como os radiofármacos. O extrato de Ginkgo Biloba (EGb) apresenta efeitos. Avaliou-se a influência de um EGb na biodisponibilidade do pertecnetato de sódio (99mTcO-4Na) e na morfometria de órgãos de ratos que foram tratados com EGb. 99mTcO-4Na foi injetado, os animais sacrificados e a radioatividade nos órgãos contada. Os resultados mostraram que o EGb alterou a biodisponibilidade do 99mTcO-4Na em rins, fígado e duodeno e alterações morfométricas significativas (p<0.05) foram encontradas. Sugere-se que o EGb poderia gerar metabólitos capazes de alterar morfometricamente os órgãos citados e alterar a biodisponibilidade do 99mTcO-4Na

Nuclear medicine methods in the assessment of acupuncture effects: a short review

“…In nuclear medicine, a radiopharmaceutical presents a normal bioavailability that might be altered due to diseases and this fact is important to define the diagnosis of a disorder. Protocols that evaluate the bioavailability of radiopharmaceuticals have permitted to investigate the influence of certain synthetic drugs (Gomes et al, 2002;Jankovic and Djokic, 2005), natural products (Moreno et al, 2004), physical exercises (Llaurado et al, 1981;Ollenberger et al, 1998) and stimulation of acupuncture points (Senna-Fernandes et al, 2006;Souza et al, 2007). Occasionally, unconventional forms of treatment can cause unexpected results when modern diagnostic procedures are applied, as occurred with the patient in the study of Kuno and Cerqueira (1995).…”

Induction of an antigen specific gut inflammatory reaction in mice and rats: a model for human Inflammatory Bowel Disease

“…Finally, the verification of similar inflammatory response in the gut of rats and mice with different genetic backgrounds validated this model of peanut allergy and provided an interesting way for the study of this mixed immune response to peanut proteins. Our group has been interested in the study of natural products derived from local plants as possible alternatives for anti-inflammatory drugs (Moreno et al, 2005). We are now conducting new experiments in which this animal model shall be used.…”

Biodistribution of technetium-99m pertechnetate after Roux-en-Y gastric bypass (Capella technique) in rats

“…After this operation, the stomach is mostly bypassed and alterations are expected to occur on biodistribution. Several drugs and surgery may interfere with the biological behavior of radiopharmaceuticals used in scintigraphic examinations and technetium-99m pertechnetate is used in more than 80% of scintigraphic examinations [12][13][14] . They may change the biological effects of the technetium-99m pertechnetate and their uptake to some organs.…”