Bioavailability of oral drugs and the methods for its improvement

Ipatova, O. M.; Torkhovskaya, T. I.; Medvedeva, N. V.; Prozorovsky, V.N.; Ivanova, N. D.; Shironin, A. V.; Баранова, В С; Archakov, A. I.

doi:10.1134/s1990750810010117

Cited by 11 publications

(8 citation statements)

References 69 publications

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“…Orekhovich Research Institute of Biomedical Chemistry (Moscow, Russia) [7]. Incorporation of drugs into PTNS is shown to sufficiently increase the therapeutic effectiveness [8]. From the point of practical applications, the information on the structure and properties of PTNS nanoparticles in different media is needed.…”

Section: Introductionmentioning

confidence: 99%

SFF analysis of the small angle scattering data for investigation of a vesicle systems structure

Zemlyanaya

Киселев

Zhabitskaya

et al. 2016

J. Phys.: Conf. Ser.

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Abstract. Experimental data on the small angle synchrotron X-ray scattering (SAXS) are analyzed on a basis of Separated form factors method (SFF) for a study of the drug delivery Phospholipid Transport Nano System (PTNS). Basic parameters of polydispersed population of PTNS nanoparticles (average radius of PTNS-particles, polydispersity of radius, thickness of membrane) have been determined. The results are discussed in comparison with the SFF results for the "classical" vesicular system of dimyristoylphosphocholine (DMPC).

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Section: Introductionmentioning

confidence: 99%

SFF analysis of the small angle scattering data for investigation of a vesicle systems structure

Zemlyanaya

Киселев

Zhabitskaya

et al. 2016

J. Phys.: Conf. Ser.

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“…For an oral nanoparticle delivery method to work effectively, it must promote efficient transport of the nanoparticle-drug complex entire, or of the drug alone following dissociation from the nanoparticle, or a combination of the two [14][15][16]. Therefore, to determine the efficacy and understand the uptake mechanisms of a formulation, it is crucial to observe the nanoparticle/drug complex on its journey through the mucus lining the GI tract, into the gut wall and further on into blood vessels.…”

Section: Biophotonicsmentioning

confidence: 99%

“…Therefore the GI mucosa has evolved to allow efficient transport of nutrients across the epithelium while rigorously excluding passage of harmful molecules and organisms. The exclusionary properties the GI mucosa present a complex set of problems to oral drug delivery [11][12][13][14][15].…”

Section: Biophotonicsmentioning

confidence: 99%

Exploring uptake mechanisms of oral nanomedicines using multimodal nonlinear optical microscopy

Garrett

Lalatsa²,

Uchegbu³

et al. 2012

Journal of Biophotonics

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Advances in pharmaceutical nanotechnology have yielded ever increasingly sophisticated nanoparticles for medicine delivery. When administered via oral, intravenous, ocular and transcutaneous delivery routes, these nanoparticles can elicit enhanced drug performance. In spite of this, little is known about the mechanistic processes underlying interactions between nanoparticles and tissues, or how these correlate with improved pharmaceutical effects. These mechanisms must be fully understood before nanomedicines can be rationally engineered to optimise their performance. Methods to directly visualise these particulates within tissue samples have traditionally involved imaging modalities requiring covalent labelling of fluorescent or radioisotope contrast agents. We present CARS, second harmonic generation and two photon fluorescence microscopy combined as a multi‐modal label‐free method for pinpointing polymeric nanoparticles within the stomach, intestine, gall bladder and liver. We demonstrate for the first time that orally administered chitosan nanoparticles follow a recirculation pathway from the GI tract via enterocytes, to the liver hepatocytes and intercellular spaces and then to the gall bladder, before being re‐released into the gut together with bile. (© 2012 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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“…In this work, on the basis of the SFF analysis of SANS experimental data, we study a structure of ULVs of the phospholipid delivery nanosystem (PTNS) obtained in the V.N.Orekhovich Research Institute of Biomedical Chemistry (Moscow, Russia). Due extremely small size of PTNS nanoparticles, the medical drugs incorporation into PTNS ULVs sufficiently improves their therapeutic effectiveness [16,17]. Estimations of basic parameters of PTNS ULVs within the frame of different approaches are presented in [18,19,20].…”

Section: Introductionmentioning

confidence: 99%

The Small-Angle Neutron Scattering Data Analysis of the Phospholipid Transport Nanosystem Structure

Zemlyanaya

Киселев

Zhabitskaya

et al. 2018

J. Phys.: Conf. Ser.

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Abstract. The small-angle neutron scattering technique (SANS) is employed for investigation of structure of the phospholipid transport nanosystem (PTNS) elaborated in the V.N.Orekhovich Institute of Biomedical Chemistry (Moscow, Russia). The SANS spectra have been measured at the YuMO small-angle spectrometer of IBR-2 reactor (Joint Institute of Nuclear Research, Dubna, Russia). Basic characteristics of polydispersed population of PTNS unilamellar vesicles (average radius of vesicles, polydispersity, thickness of membrane, etc.) have been determined in three cases of the PTNS concentrations in D2O: 5%, 10%, and 25%. Numerical analysis is based on the separated form factors method (SFF). The results are discussed in comparison with the results of analysis of the small-angle X-ray scattering spectra collected at the Kurchatov Synchrotron Radiation

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Bioavailability of oral drugs and the methods for its improvement

Cited by 11 publications

References 69 publications

SFF analysis of the small angle scattering data for investigation of a vesicle systems structure

SFF analysis of the small angle scattering data for investigation of a vesicle systems structure

Exploring uptake mechanisms of oral nanomedicines using multimodal nonlinear optical microscopy

The Small-Angle Neutron Scattering Data Analysis of the Phospholipid Transport Nanosystem Structure

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