Bioavailability of milk protein-derived bioactive peptides: a glycaemic management perspective

Horner, Katy; Drummond, Elaine; Brennan, Lorraine

doi:10.1017/s0954422416000032

Cited by 45 publications

(32 citation statements)

References 119 publications

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“…However, several studies have shown that whey protein’s effects on insulin and incretin secretion are modulated by its unique profile of bioactive peptides [97,98], which are released exogenously through food processing and endogenously through gastrointestinal digestion [98]. Whey proteins, caseins, and their bioactive peptides have all been shown to have potent glucoregulatory effects in healthy adults and in individuals with T2DM [97,99,100,101,102,103]. Mechanistically, bioactive peptides generated from the digestion of dairy proteins may have direct effects on insulin secretion, incretin secretion [96,104,105], and/or attenuation of incretin breakdown through inhibition of the incretin breakdown enzyme dipeptidyl peptidase 4 (DPP-4) [106,107].…”

Section: Dairy Foods and Dairy Protein Supplements Are Associated mentioning

confidence: 99%

Emerging Evidence for the Importance of Dietary Protein Source on Glucoregulatory Markers and Type 2 Diabetes: Different Effects of Dairy, Meat, Fish, Egg, and Plant Protein Foods

Comerford

Pasin

2016

Nutrients

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Observational studies provide evidence that a higher intake of protein from plant-based foods and certain animal-based foods is associated with a lower risk for type 2 diabetes (T2DM). However, there are few distinguishable differences between the glucoregulatory qualities of the proteins in plant-based foods, and it is likely their numerous non-protein components (e.g., fibers and phytochemicals) that drive the relationship with T2DM risk reduction. Conversely, the glucoregulatory qualities of the proteins in animal-based foods are extremely divergent, with a higher intake of certain animal-based protein foods showing negative effects, and others showing neutral or positive effects on T2DM risk. Among the various types of animal-based protein foods, a higher intake of dairy products (such as milk, yogurt, cheese and whey protein) consistently shows a beneficial relationship with glucose regulation and/or T2DM risk reduction. Intervention studies provide evidence that dairy proteins have more potent effects on insulin and incretin secretion compared to other commonly consumed animal proteins. In addition to their protein components, such as insulinogenic amino acids and bioactive peptides, dairy products also contain a food matrix rich in calcium, magnesium, potassium, trans-palmitoleic fatty acids, and low-glycemic index sugars—all of which have been shown to have beneficial effects on aspects of glucose control, insulin secretion, insulin sensitivity and/or T2DM risk. Furthermore, fermentation and fortification of dairy products with probiotics and vitamin D may improve a dairy product’s glucoregulatory effects.

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Section: Dairy Foods and Dairy Protein Supplements Are Associated mentioning

confidence: 99%

Emerging Evidence for the Importance of Dietary Protein Source on Glucoregulatory Markers and Type 2 Diabetes: Different Effects of Dairy, Meat, Fish, Egg, and Plant Protein Foods

Comerford

Pasin

2016

Nutrients

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“…Note that these peptides were not included in the learning set to construct the GCNN models. [51] Lactotripeptide was predicted to interact with DPP4 because it is a peptide derived from milk protein and the second amino acid is proline. The target protein candidate predicted with the highest prediction score was the angiotensin I-converting enzyme (ACE).…”

Section: New Prediction Of Target Proteins and Health Effects Of Foodmentioning

confidence: 99%

Prediction of the Health Effects of Food Peptides and Elucidation of the Mode‐of‐action Using Multi‐task Graph Convolutional Neural Network

Fukunaga

Sawada

Shibata

et al. 2019

Molecular Informatics

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Food proteins work not only as nutrients but also modulators for the physiological functions of the human body. The physiological functions of food proteins are basically regulated by peptides encrypted in food protein sequences (food peptides). In this study, we propose a novel deep learning-based method to predict the health effects of food peptides and elucidate the mode-of-action. In the algorithm, we estimate potential target proteins of food peptides using a multi-task graph convolutional neural network, and predict its health effects using information about therapeutic targets for diseases. We constructed predictive models based on 21,103 peptide-protein interactions involving 10,950 peptides and 2,533 proteins, and applied the models to food peptides (e. g., lactotripeptide, isoleucyltyrosine and sardine peptide) defined in food for specified health use. The models suggested potential effects such as blood-pressure lowering effects, blood glucose level lowering effects, and anti-cancer effects for several food peptides. The interactions of food peptides with target proteins were confirmed by docking simulations.Keywords: foods · peptides · health effects · peptide-protein interaction · graph convolutional neural network · deep learning[a] I.

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“…Such peptides, initially identified in vitro in the protein hydrolysates, must reach the target site/organ in the bioactive form. Whether or not the peptides reach the target site/organ depends on the way they are transported from the gastrointestinal tract to bloodstream in the concentration ensuring their biological effect (Horner and others ). Horner and others () discussed the factors affecting the bioavailability of milk‐derived peptides helpful in diabetes management.…”

Section: Multifunctional Character Of Msyn‐preventing Peptidesmentioning

confidence: 99%

Peptides Derived from Foods as Supportive Diet Components in the Prevention of Metabolic Syndrome

Iwaniak

Darewicz

Minkiewicz

2017

Comp Rev Food Sci Food Safe

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Metabolic syndrome (MSyn) includes physiological, biochemical, clinical, and metabolic abnormalities, leading to an increase in health problems like obesity, dyslipidemia, cardiovascular diseases, and diabetes, which contribute to an increase in mortality rate. One of the main factors having a key impact on our health is the food we consume. Thus, scientists work towards the discovery of novel bioactive compounds with therapeutic potential to address MSyn. According to scientific reports, peptides derived from food proteins exhibit bioactivities important for the prevention of MSyn diseases; that is, they regulate blood pressure and glycemia; reduce cholesterol level and body mass; and scavenge free radicals. The aim of this review is to study the potential role of peptides in the prevention of MSyn. Particularly peptides which exhibit the following activities: antihypertensive [angiotensin-converting enzyme (ACE) inhibition (EC 3.4.15.1)], antidiabetic [dipeptidyl peptidase IV (DPP-IV) (EC 3.4.14.5)/α-glucosidase (EC 3.2.1.20)/α-amylase (EC 3.2.1.1) inhibition)], cholesterol level reduction, antioxidative, and obesity prevention, were studied. If possible, special attention is paid in the review to the bioactivities of peptides that were measured in vivo. Some examples of peptides showing dual or multiple action against MSyn targets are presented. Moreover, using the database of bioactive peptide sequences (BIOPEP) we made a list of peptides serving simultaneous functions in counteracting MSyn dysfunctions. Such an approach may simplify the discovery of MSyn preventive peptides, as well as highlight some of them as potent bioactive ingredients that may be incorporated into foods. Moreover, the research strategy involving the in silico and in vitro/in vivo methodologies may be useful in the production of food protein hydrolysates supporting the treatment of MSyn dysfunctions.

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Bioavailability of milk protein-derived bioactive peptides: a glycaemic management perspective

Cited by 45 publications

References 119 publications

Emerging Evidence for the Importance of Dietary Protein Source on Glucoregulatory Markers and Type 2 Diabetes: Different Effects of Dairy, Meat, Fish, Egg, and Plant Protein Foods

Emerging Evidence for the Importance of Dietary Protein Source on Glucoregulatory Markers and Type 2 Diabetes: Different Effects of Dairy, Meat, Fish, Egg, and Plant Protein Foods

Prediction of the Health Effects of Food Peptides and Elucidation of the Mode‐of‐action Using Multi‐task Graph Convolutional Neural Network

Peptides Derived from Foods as Supportive Diet Components in the Prevention of Metabolic Syndrome

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