Bioavailability and Antioxidant Activity of Some Food Supplements in Men and Women Using the D-Roms Test as a Marker of Oxidative Stress

Cornelli, Umberto; Terranova, R; Luca, S. De; Cornelli, M.; Alberti, Angelo

doi:10.1093/jn/131.12.3208

Cited by 189 publications

(156 citation statements)

References 12 publications

Supporting

Mentioning

152

Contrasting

Order By: Relevance

“…Measurement of d-ROMs in blood has been reported as indicative of oxidative stress (Ridker et al, 2004) and already used as an oxidative stress index in human, calves and pigs (Cornelli et al, 2001;Ballerini et al, 2003;Brambilla et al, 2003). In this study, B pigs had lower d-ROMs levels than LW pigs regardless of their housing environment, which is in agreement with the hypothesis of a better redox status in rustic slow-growing pigs relative to fast-growing pigs (Brambilla et al, 2002).…”

Section: Discussionsupporting

confidence: 87%

Health and immune traits of Basque and Large White pigs housed in a conventional or enriched environment

Merlot

Vincent

Thomas

et al. 2012

Animal

View full text Add to dashboard Cite

Since decades, production traits such as growth rate, feed efficiency or body composition have been drastically increased in pigs by genetic selection. Whether this selection impacted animal robustness is still unclear. In this study, we compared Large White (LW) pigs, a breed submitted to intense genetic selection for production traits, and Basque (B) pigs, a local rustic breed, reared in two different housing environments (conventionalv.enriched). Adaptation to housing conditions among each breed was evaluated at the level of endocrine and immune traits. These are known to be impacted by housing conditions and breed; however, the interaction effects between genotype and environment are less described. Animals (20 per breed and housing environment) entered the experiment at 35 kg of live weight. Levels of cortisol, acute-phase inflammatory proteins, immunoglobulins and hydrogen peroxide, blood formula, lymphocyte proliferation andin-vitrocytokine expression were measured at ∼115 kg of live weight. Animals were checked for skin injuries during the growing period. At slaughter, at the average live weight of 145 kg, carcasses were examined for pathological conditions of the respiratory tract. The major result was that the two breeds exhibited differences in response to the housing environment. Among the 24 sanitary, endocrine or immune traits investigated, the housing conditions affected eight variables in both breeds (salivary cortisol at 0700 and 1900 h, severity of pneumonia at slaughter) or only in B pigs (severe skin lesions) or LW pigs (salivary cortisol at 1500 h, granulocyte numbers and lymphocyte/granulocyte ratio and lymphocyte proliferation). These observations strengthen the hypothesis that selection for high meat production level might be associated with an increased susceptibility of animals to environmental stressors.

show abstract

Section: Discussionsupporting

confidence: 87%

Health and immune traits of Basque and Large White pigs housed in a conventional or enriched environment

Merlot

Vincent

Thomas

et al. 2012

Animal

View full text Add to dashboard Cite

show abstract

“…However, in previous experiments [15] the antioxidants intake for a longer period of time (one week) was found to reduce significantly the plasma hydroperoxides levels.…”

Section: Discussionmentioning

confidence: 79%

“…The d-ROMs test in plasma as measure of hydroperoxides [15], a marker of the whole cellular oxidation; the test for isoprostanes (8-Iso-PGF 2α) in plasma as measure of the oxidation of cellular membranes [16]; the test for 8-OHdG in urine as marker of DNA oxidation [17]; the test for carbonylated proteins in plasma as marker for oxidized proteins [18]; the test for hs-CRP that indicates a generic inflammatory condition [19]; the Soluble Antioxidant Test that measures the antioxidant capacity (AC) in plasma (PAT), urine (UAT) and saliva (SAT).…”

Section: Methodsmentioning

confidence: 99%

The Oxidative Stress Balance Measured in Humans with Different Markers, Following a Single Oral Antioxidants Supplementation or a Diet Poor of Antioxidants

Cornelli¹,

Belcaro²,

Finco³

2011

JCDSA

View full text Add to dashboard Cite

show abstract

“…23, 24 The d-ROM test depends on a Fenton-like reaction to produce lipid peroxy and alkoxy radicals that in turn react with a chromogenic substrate. 23 …”

Section: Measurement Of Derivatives Of Reactive Oxygen Metabolites Inmentioning

confidence: 99%

Renin-Angiotensin System Inhibitors Can Prevent Intravenous Lipid Infusion-Induced Myocardial Microvascular Dysfunction and Leukocyte Activation

Yasu

Mutoh

Wada

et al. 2018

Circ J

View full text Add to dashboard Cite

Background: Levels of triglycerides and free fatty acids (FFAs) are elevated in patients with diabetes and may contribute to endothelial dysfunction through renin-angiotensin system (RAS) activation and oxidative stress. The present study investigated how systemic FFA loading affected myocardial microcirculation during hyperemia via RAS. Methods and Results:Eight healthy men received candesartan, perindopril, or a placebo for 2 days in a double-blind crossover design, and then myocardial microcirculation during hyperemia induced by a 2-h infusion of lipid/heparin was assessed using dipyridamole stress-myocardial contrast echocardiography (MCE). Leukocyte activity and hemorheology were also assessed ex vivo using a microchannel flow analyzer, serum levels of oxidative stress markers, and IκB-α expression in mononuclear cells. Serum FFA elevation by the infusion of lipid/heparin significantly decreased myocardial capillary blood velocity and myocardial blood flow during hyperemia. Both candesartan and perindopril significantly prevented the FFA-induced decrease in capillary blood velocity and myocardial blood flow during hyperemia. Systemic FFA loading also caused an increase in the number of adherent leukocytes and prolonged the whole blood passage time. These effects were blocked completely by candesartan and partially by perindopril. Both agents prevented the FFA-induced enhancement of oxidative stress and IκB-α degradation in mononuclear cells. Conclusions:Both candesartan and perindopril can prevent FFA-induced myocardial microcirculatory dysfunction during hyperemia via modulation of leukocyte activation and microvascular endothelial function.

show abstract

Bioavailability and Antioxidant Activity of Some Food Supplements in Men and Women Using the D-Roms Test as a Marker of Oxidative Stress

Cited by 189 publications

References 12 publications

Health and immune traits of Basque and Large White pigs housed in a conventional or enriched environment

Health and immune traits of Basque and Large White pigs housed in a conventional or enriched environment

The Oxidative Stress Balance Measured in Humans with Different Markers, Following a Single Oral Antioxidants Supplementation or a Diet Poor of Antioxidants

Renin-Angiotensin System Inhibitors Can Prevent Intravenous Lipid Infusion-Induced Myocardial Microvascular Dysfunction and Leukocyte Activation

Contact Info

Product

Resources

About