The Oxidative Stress Balance Measured in Humans with Different Markers, Following a Single Oral Antioxidants Supplementation or a Diet Poor of Antioxidants

Cornelli, Umberto; Belcaro, G; Finco, Annarosa

doi:10.4236/jcdsa.2011.13011

Cited by 8 publications

(8 citation statements)

References 24 publications

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“…[16]. The measure of ROOH is one of the simplest and more sensible marker of oxidation [17] and they are largely of lipidic nature (therefore including isoprostanes), but they also consist of carbonylated proteins and oxidized nucleic acids. Because of this large valence ROOH can be consider a reliable method to measure the oxidation in plasma.…”

Section: Redox Balance Analysis: Os/aormentioning

confidence: 99%

Redox State in Professional Cyclists Following Competitive Sports Activity

Corsetti¹

2012

TOSMJ

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Abstract:Introduction: Measuring oxidative stress (OS) and antioxidant reserve (AOR) may be useful in assessing the physical condition of athletes taking part in competitive sports activities.Aim: During the "Giro d'Italia" in May 2011, the redox state of an entire cycle racing team was monitored to determine the risk of cyclists developing "redox inflammation", which might herald the onset of pathological conditions. Materials and Methods:The nine members of the Liquigas cycle racing team were analyzed using a FRAS 4 Evolvo System. OS was determined by measuring plasma hydroperoxides (d-ROMs test) and AOR by measuring water-soluble antioxidants in the plasma (BAP test). The latter was expressed in terms of μEq of Vitamin C. Both measurements were carried out at four different times during the race: baseline, in the morning two days before the start [B]; in the morning of the rest day after 9 stages [M1]; in the evening after the most stressing mountain stage [MS]; in the morning before the start of the last stage [M2]. Each cyclist's performance was determined at the end of the race according to an ordinal scale ranging from 1 to 9. Conclusions:Redox balance assessment is a useful tool to: a) monitor athletic performance and predict the onset of redox inflammatory state (RI), which might be detrimental to the athlete's physical condition; b) propose suitable supplementation with particular foods and dietary supplements.

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Section: Redox Balance Analysis: Os/aormentioning

confidence: 99%

Redox State in Professional Cyclists Following Competitive Sports Activity

Corsetti¹

2012

TOSMJ

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“…The markers analyzed were related exclusively to lipids peroxidation, whereas the condition of oxidative stress is affecting many other compounds such as proteins, DNA and sugars. These derivatives taken all together can give a more sensible picture of OS, as it is the case of the hydroperoxides levels in plasma which allow a more complete although nonspecific evaluation of OS [3]. …”

Section: Introductionmentioning

confidence: 99%

“…A comparative analysis has been done among the most common markers [3] reaching the conclusion that d-ROMs test seems to be the most reliable.…”

Section: Introductionmentioning

confidence: 99%

Analysis of oxidative stress during the menstrual cycle

Cornelli

Belcaro

Cesarone

et al. 2013

Reprod Biol Endocrinol

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BackgroundFew data concerning the oxidative stress (OS) in plasma during the entire menstrual cycle of eumenorrheic women are available.MethodsOS was assessed in 20 healthy volunteers during the phase of the menstrual cycle by determining the plasmatic hydroperoxides levels (d-ROMs test). The assessment was performed every three days, starting from the first day (t1) up the end of the menstrual phase (t27). Concomitantly, the estrogen (E2) and progestin (P4) levels were determined at the same time intervals.ResultsFrom a base value (t1) of 284 +/− 38.0 CARR.U., which is essentially within the normal range (<300 Carratelli units or CARR.U.), the OS levels progressively increased to 378 +/− 115 CARR.U. at t15, and then slightly decreased over the subsequent time but with average values >300 CARR.U. Analysis of the E2 levels showed that the maximum OS values were noticed near the estrogen peak, while remaining above the base levels, and then decreased during the progestin phase until returning to normal at the end of the menstrual cycle.ConclusionsIt may concludes that the healthy women go into OS for 2/3 of the menstrual cycle.

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“…A very simple method that can be used to measure oxidative stress is related to hydroperoxides content in plasma which is considered a very reliable test compared to other common methods since it shows very limited coefficient of variation [25]. …”

Section: Discussionmentioning

confidence: 99%

Levothyroxine and lung cancer in females: the importance of oxidative stress

Cornelli

Belcaro

Recchia

et al. 2013

Reprod Biol Endocrinol

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BackgroundLevothyroxine (LT4) treatment can lead to iatrogenic hyperthyroidism and oxidative stress that can cause patient discomfort. Oxidative stress is also recognized as one of the causes of chronic diseases and cancer.MethodsThe prevalence of breast, colorectal, gastric and lung cancer in 18 Italian Regions during 2010 was correlated with the sales of LT4 in 2009. The cancer prevalence was analyzed in women aged 30–84. This age range corresponds to more than 80% of the consumers of the drug and to about 99% of all malignant cancers. The correlation between sales of LT4 and cancers was determined with the technique of Density Ellipses. The age and smoking contribution for lung cancer was determined with the Sequential test.ResultsNo significant correlation was seen between LT4 sales and breast, colorectal and gastric cancers. A significant correlation was instead found for lung cancer (p < 0.05) corrected for smoking and age.ConclusionsLT4 consumption in Italy is about 0.7 boxes/women/year. There is a correlation between lung cancer and LT4 treatment and oxidative stress caused by LT4 supplementation can be one of the causes. Although we cannot exclude that dysthyroidism needing LT4 supplementation might be the ground for lung cancer itself and measuring oxidative stress could be helpful in avoiding excessive use of the drug.

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The Oxidative Stress Balance Measured in Humans with Different Markers, Following a Single Oral Antioxidants Supplementation or a Diet Poor of Antioxidants

Abstract: ABSTRACT

Cited by 8 publications

References 24 publications

Redox State in Professional Cyclists Following Competitive Sports Activity

Redox State in Professional Cyclists Following Competitive Sports Activity

Analysis of oxidative stress during the menstrual cycle

Levothyroxine and lung cancer in females: the importance of oxidative stress

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