Bioassay‐guided separation of citreorosein and other oestrogenic compounds From <i>Polygonum cuspidatum</i>

Zhang, Caining; Wang, Xuman; Zhang, Xiaozhe; Zhang, Yan; Xiao, Hongbin; Liang, Xinmiao

doi:10.1002/ptr.2619

Cited by 20 publications

(14 citation statements)

References 4 publications

(5 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Stilbenes (resveratrol and piceid) [17] and their glycosides [18] and anthranoids (emodin, physcion, anthraglycoside B, citreorosein, emodin 8-O-β-D-glucopyranoside) [17], [19], [20] and phenolic saccharides [21] have been found in F. japonica . Among these, emodin has known cathartic, anti-inflammatory [22], anti-cancer, anti-microbial, diuretic, DNA-binding, and vasorelaxant activities [23], [24], [25]; emodin and physcion showed cytotoxicity against cancer cells [24], [26]; and emodin, citreorosein and emodin 8-O-β-D-glucopyranoside showed phytoestrogen activity [20], [27], [28]. In addition, emodin and physcion appeared to be kinase and tyrosinase inhibitors [16], [29], [30].…”

Section: Introductionmentioning

confidence: 99%

Combined Phytochemistry and Chemotaxis Assays for Identification and Mechanistic Analysis of Anti-Inflammatory Phytochemicals in Fallopia japonica

et al. 2011

View full text Add to dashboard Cite

Plants provide a rich source of lead compounds for a variety of diseases. A novel approach combining phytochemistry and chemotaxis assays was developed and used to identify and study the mechanisms of action of the active compounds in F. japonica, a medicinal herb traditionally used to treat inflammation. Based on a bioactivity-guided purification strategy, two anthranoids, emodin and physcion, were identified from F. japonica. Spectroscopic techniques were used to characterize its crude extract, fractions and phytochemicals. The crude extract, chloroform fraction, and anthranoids of F. japonica significantly inhibited CXCR4-mediated chemotaxis. Mechanistic studies showed that emodin and physcion inhibited chemotaxis via inactivating the MEK/ERK pathway. Moreover, the crude extract and emodin could prevent or treat type 1 diabetes in non-obese diabetic (NOD) mice. This study illustrates the applicability of a combinational approach for the study of anti-inflammatory medicine and shows the potential of F. japonica and its anthranoids for anti-inflammatory therapy.

show abstract

Section: Introductionmentioning

confidence: 99%

Combined Phytochemistry and Chemotaxis Assays for Identification and Mechanistic Analysis of Anti-Inflammatory Phytochemicals in Fallopia japonica

et al. 2011

View full text Add to dashboard Cite

show abstract

“…It may be useful for hormone replacement therapy against human menoxenia and post-menopausal diseases [53]. Citreorosein, a naturally occurring anthraquinone derivative from Hu Zhang, was found to exert estrogenic activity by using a recombinant assay [55]. …”

Section: Pharmacological Activitiesmentioning

confidence: 99%

A Review of the Pharmacological Effects of the Dried Root ofPolygonum cuspidatum(Hu Zhang) and Its Constituents

Zhang

Kwok

et al. 2013

Evidence-Based Complementary and Alternative Medicine

View full text Add to dashboard Cite

Traditional Chinese medicine (TCM) has been widely used in China for thousands of years to treat and prevent diseases. TCM has been proven safe and effective, and it is being considered as one of the important types of complementary and alternative medicine and receives increasing attention worldwide. The dried root of Polygonum cuspidatum Sieb. et Zucc. (also known as “Hu Zhang” in Chinese) is one of the medicinal herbs listed in the Pharmacopoeia of the People's Republic of China. Hu Zhang is widely distributed in the world. It can be found in Asia and North America and is used as folk medicine in countries such as Japan and Korea. In China, Hu Zhang is usually used in combination with other TCM herbs. The therapeutic uses of those Hu Zhang-containing TCM prescriptions or formulations are for treating cough, hepatitis, jaundice, amenorrhea, leucorrhea, arthralgia, burns and snake bites. Recent pharmacological and clinical studies have indicated that Hu Zhang has antiviral, antimicrobial, anti-inflammatory, neuroprotective, and cardioprotective functions. This review gives a summary of the reported therapeutic effects of the active compounds and the different extracts of Hu Zhang.

show abstract

“…19) Among the anthraquinone derivatives, Citreorosein (CIT) has been shown to have oestrogenic and tyrosinase-inhibitory activities. 20,21) Quite recently, we reported Regular Article * To whom correspondence should be addressed. e-mail: jkson@yu.ac.kr; hwchang@yu.ac.kr…”

Section: )mentioning

confidence: 99%

Citreorosein Inhibits Production of Proinflammatory Cytokines by Blocking Mitogen Activated Protein Kinases, Nuclear Factor-κB and Activator Protein-1 Activation in Mouse Bone Marrow-Derived Mast Cells

Suh

et al. 2012

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Bioassay‐guided separation of citreorosein and other oestrogenic compounds From Polygonum cuspidatum

Abstract: Citreorosein was isolated from P. cuspidatum as a new oestrogenic compound, together with emodin and its glucoside, by silica gel column chromatography and preparative high-performance liquid chromatography sequentially. Oestrogenic activity was determined by a recombinant yeast assay.

Cited by 20 publications

References 4 publications

Combined Phytochemistry and Chemotaxis Assays for Identification and Mechanistic Analysis of Anti-Inflammatory Phytochemicals in Fallopia japonica

Combined Phytochemistry and Chemotaxis Assays for Identification and Mechanistic Analysis of Anti-Inflammatory Phytochemicals in Fallopia japonica

A Review of the Pharmacological Effects of the Dried Root ofPolygonum cuspidatum(Hu Zhang) and Its Constituents

Citreorosein Inhibits Production of Proinflammatory Cytokines by Blocking Mitogen Activated Protein Kinases, Nuclear Factor-κB and Activator Protein-1 Activation in Mouse Bone Marrow-Derived Mast Cells

Contact Info

Product

Resources

About