Citreorosein Inhibits Production of Proinflammatory Cytokines by Blocking Mitogen Activated Protein Kinases, Nuclear Factor-κB and Activator Protein-1 Activation in Mouse Bone Marrow-Derived Mast Cells

Lu, Yue; Suh, Sungho; Li, Xian; Liang, Jing; Chi, Meijuan; Hwangbo, Kyoung; Kwon, Okyun; Chung, Tae‐Wook; Kwak, Choong Hwan; Kwon, Kyung-Min; Murakami, Makoto; Jahng, Yurngdong; Kim, Cheorl-Ho; Son, Jong‐Keun; Chang, Hyeun Wook

doi:10.1248/bpb.35.938

Cited by 8 publications

(5 citation statements)

References 34 publications

(30 reference statements)

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“…other findings offers that NFκB and AP-1 can inhibit the production of MMP9 and proinflammatory cytokine. 28,29 Our finding indirectly showed that NFκB might act a synergistic role in M-CSF-MAPK-AP-1-related RAW 264.7 to M2 macrophages transformation. The co-immunoprecipitation experiments observed that c-Jun interacted with p50 NFκB in the presence of rM-CSF.…”

Section: Discussionmentioning

confidence: 65%

M-CSF cooperating with NFκB induces macrophage transformation from M1 to M2 by upregulating c-Jun

Yang

Qin

Lan

et al. 2013

Cancer Biology & Therapy

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Section: Discussionmentioning

confidence: 65%

M-CSF cooperating with NFκB induces macrophage transformation from M1 to M2 by upregulating c-Jun

Yang

Qin

Lan

et al. 2013

Cancer Biology & Therapy

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“…Following this pharmaceutical hit with emodin, studies about anthraquinones were expanded with the addition of bromo (brominated anthraquinones exist in some marine fungal biomasses), nitro, amino or bromoacetamido groups, and many compounds were also active ( Table 3 ). Citreorosein (ω-hydroxyemodin) demonstrated similar kinase-inhibiting properties [ 219 ], and this kinase inhibiting action of anthraquinones was further linked to an anti-hypertensive potential as therapeutic agents [ 220 ]. Thereby, it would be very interesting to investigate the properties of the very large list of natural anthraquinones (over 100 compounds) produced by marine and marine-derived fungi, gathered for the first time in this review ( Table 2 ).…”

Section: In Vitro Biological Activities Of Natumentioning

confidence: 99%

Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities

et al. 2016

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Anthraquinones and their derivatives constitute a large group of quinoid compounds with about 700 molecules described. They are widespread in fungi and their chemical diversity and biological activities recently attracted attention of industries in such fields as pharmaceuticals, clothes dyeing, and food colorants. Their positive and/or negative effect(s) due to the 9,10-anthracenedione structure and its substituents are still not clearly understood and their potential roles or effects on human health are today strongly discussed among scientists. As marine microorganisms recently appeared as producers of an astonishing variety of structurally unique secondary metabolites, they may represent a promising resource for identifying new candidates for therapeutic drugs or daily additives. Within this review, we investigate the present knowledge about the anthraquinones and derivatives listed to date from marine-derived filamentous fungi′s productions. This overview highlights the molecules which have been identified in microorganisms for the first time. The structures and colors of the anthraquinoid compounds come along with the known roles of some molecules in the life of the organisms. Some specific biological activities are also described. This may help to open doors towards innovative natural substances.

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“…Chrysophanol can inhibit the growth of HeLa cervical cancer cells ( Trybus et al, 2021 ). Citreorosein suppresses the gene expression of proinflammatory cytokines, including tumor necrosis factor (TNF)-α, interleukin (IL)-6 and IL-1β, in mouse bone marrow-derived mast cells (BMMCs) stimulated with phorbol 12-myristate 13-acetate (PMA) plus the calcium ionophore A23187 ( Lu et al, 2012 ). Questinol can significantly inhibit NO production at the indicated concentrations and has also been found to inhibit the production of proinflammatory cytokines, including TNF-α and IL-1β ( Yang X. et al, 2014 ), while CG at low concentrations (12 and 24 μM) significantly increase L-02 cell viability ( Liu et al, 2018 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics, Tissue Distribution, and Excretion Characteristics of a Radix Polygoni Multiflori Extract in Rats

Cheng

Yuan

et al. 2022

Front. Pharmacol.

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Although progress has been achieved in the pharmacological activity and toxicity of Radix Polygoni Multiflori (RPM), the chemical basis of its toxicity is still unclear. Here, we performed a multicompound pharmacokinetic analysis and investigated the tissue distribution and excretion characteristics of RPM components after oral administration in rats. The findings demonstrated that the active ingredients of the RPM extract were quickly absorbed after oral administration, with high exposure levels of emodin, 2,3,5,4′-teterahydroxystilbene-2-O-β-D-glucoside (TSG), citreorosein, torachrysone-8-O-glucoside (TG), emodin-8-O-β-D-glucoside (EG), and physcion-8-O-β-D-glucoside (PG). The tissue distributions of emodin, TSG, TG, EG, and PG were high in the liver and kidney. These components were the key contributors to the effectiveness and toxicity of RPM on the liver and kidney. Most of the active ingredients were mainly excreted through feces and bile, while a few were converted into other products in the body and excreted through urine and feces.

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Citreorosein Inhibits Production of Proinflammatory Cytokines by Blocking Mitogen Activated Protein Kinases, Nuclear Factor-κB and Activator Protein-1 Activation in Mouse Bone Marrow-Derived Mast Cells

Cited by 8 publications

References 34 publications

M-CSF cooperating with NFκB induces macrophage transformation from M1 to M2 by upregulating c-Jun

M-CSF cooperating with NFκB induces macrophage transformation from M1 to M2 by upregulating c-Jun

Anthraquinones and Derivatives from Marine-Derived Fungi: Structural Diversity and Selected Biological Activities

Pharmacokinetics, Tissue Distribution, and Excretion Characteristics of a Radix Polygoni Multiflori Extract in Rats

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