Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)

Sénejoux, François; Demougeot, Céline; Kerram, Parhat; Aisa, Haji Akber; Berthelot, Alain; Bévalot, Françoise; Girard, Christian

doi:10.1016/j.fitote.2011.11.023

Cited by 34 publications

(25 citation statements)

References 22 publications

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“…The contractile response to CaCl2 was expressed as a percentage of the maximal contraction induced by K + (60 mmol/L) in standard Krebs solution. In the control group, the EC50 of the extract was applied for 10 min before KCl addition (Senejoux et al, 2012).…”

Section: Effect On Extracellular Calcium-induced Contractionmentioning

confidence: 99%

Antihypertensive effect of piperitenone oxide on spontaneously hypertensive rat by regulating calcium balance and reducing endothelin-1 secretion

Lan

Zhang

Wang

et al. 2017

Bangladesh J Pharmacol

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effect of piperitenone oxide on spontanepiperitenone oxide on spontanepiperitenone oxide on spontaneously hypertensive rat by regulating ously hypertensive rat by regulating ously hypertensive rat by regulating calcium balance and reducing encalcium balance and reducing encalcium balance and reducing endothelin dothelin dothelin---1 secretion 1 secretion 1 secretion BJP IntroductionHypertension is an important risk factor for the cardiovascular disease, cerebrovascular disease and kidney failure worldwide, causing an estimated 7.5 million deaths per year (World Health Organization, 2009 AbstractThe purpose of this study was to investigate the antihypertensive mechanisms of piperitenone oxide in spontaneously hypertensive rat (SHR). Compared to control SHR, piperitenone oxide reduced the systolic blood pressure and serum endothelium-1 (ET-1). The nitric oxide (NO) production and ET-1 secretion were significantly inhibited in the noradrenaline-exposed bovine aortic endothelial cells. Piperitenone oxide showed endothelium-independent but concentration-dependent relaxation of the artery rings. The responsible mechanisms appear to be related to the modulation of ET-1 and NO levels. The vasorelaxant effect of piperitenone oxide is independent of endotheliumderived mediators, which is associated with interfering intracellular calcium homeostasis by blocking Ca 2+ influx, as well as intracellular Ca 2+ release. Article InfoReceived: 2 May 2017 Accepted:31

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Section: Effect On Extracellular Calcium-induced Contractionmentioning

confidence: 99%

Antihypertensive effect of piperitenone oxide on spontaneously hypertensive rat by regulating calcium balance and reducing endothelin-1 secretion

Lan

Zhang

Wang

et al. 2017

Bangladesh J Pharmacol

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“…From flavonoids, only a limited number of glycosides (diosmin (7) and linarin (8)) was isolated. [39,61] Low vasorelaxant activity (IC50 not calc.) [39] Toxicity against Artemia salina larvae [62] Antiradical [63] Weak antibacterial effect [ [39,61] Low vasorelaxant activity (IC50 not calc.)…”

Section: Phenolicsmentioning

confidence: 99%

“…[39,61] Low vasorelaxant activity (IC50 not calc.) [39] Toxicity against Artemia salina larvae [62] Antiradical [63] Weak antibacterial effect [ [39,61] Low vasorelaxant activity (IC50 not calc.) [39] Toxicity against Artemia salina larvae [62] Antiradical [63] Weak antibacterial effect [61] OH OCH3 OCH3 OCH3 OH H Acacetin (5) Z. clinopodioides [39] Low vasorelaxant activity (IC50 not calc.)…”

Section: Phenolicsmentioning

confidence: 99%

“…[39] Toxicity against Artemia salina larvae [62] Antiradical [63] Weak antibacterial effect [ [39,61] Low vasorelaxant activity (IC50 not calc.) [39] Toxicity against Artemia salina larvae [62] Antiradical [63] Weak antibacterial effect [61] OH OCH3 OCH3 OCH3 OH H Acacetin (5) Z. clinopodioides [39] Low vasorelaxant activity (IC50 not calc.) [39] Inhibition of angiogenesis [64,65] Induction of apoptosis in different cancer cell lines [66][67][68][69][70] Inhibition of TNF-related apoptosis [71] Anticancer [72,73] Induction of melanogenesis in B16F10 cells [74] Cytotoxic against HL-60 cells cells [75] Interaction with telomeres [76] Antimetastatic effect [77,78] Diosmetin (6) Z. clinopodioides [4] Some inhibitory activity on NO production stimulated by LPS and IFN-γ in RAW 264.7 cells [4] Cytotoxic against HL-60 cells cells [75] Induction of melanogenesis in B16F10 cells [73,74] Review on bioactivity [79] H OH H OH OCH 3 H Diosmin (7) Z. clinopodioides [80] Antidiabetic activity (reviewed by Abdurrazak et al [81]) Review on clinical use [82] H O-Glc-Rha H OH OCH 3 Hf Linarin (8) Z. clinopodioides [44,80] Inhibition of mucin production and secretion in airways epithelial cells …”

Section: Phenolicsmentioning

confidence: 99%

“…Linarin (8) Z. clinopodioides [44,80] Inhibition of mucin production and secretion in airways epithelial cells [83] Hepatoprotective [84] Potential inhibitor of CDK4 in retinoblastoma [85] Neuroprotective [86] Inhibition of acetylcholinesterase [87] Anti-inflammatory [88]; Anti-inflammatory in vivo [89] Depressant effect on CNS [90,91] H [39] Low vasorelaxant activity (IC50 not calc.) [39] Review on its potential in treatment of cardiovascular diseases [92] Review on its potential in treatment of neurodegenerative diseases [93] R1 R2…”

Section: Chemical Structurementioning

confidence: 99%

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Kazakh Ziziphora Species as Sources of Bioactive Substances

et al. 2016

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Ziziphora species represent the prototypical example of the Lamiaceae family. The phytochemicals present in Ziziphora include monoterpenic essential oils, triterpenes and phenolic substances belonging to the flavonoids. In Kazakh traditional medicine, Ziziphora species possess several medicinal uses. In particular, Z. bungeana Lam. and Z. clinopodioides Lam. are used for the treatment of illnesses related to the cardiovascular system or to combat different infections. Unfortunately, the majority of the information about the complex Ziziphora species is only available in Russian and Chinese language, therefore, we decided gather all available information on Kazakhstan Ziziphora, namely its content compounds, medicinal uses and published patents, to draw the attention of scientists to this very interesting plant with high medicinal potential.

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Protective effects of Ziziphora tenuior extract against chlorpyrifos induced liver and lung toxicity in rat: Mechanistic approaches in subchronic study

Yazdinezhad

Abbasian

Hosseini

et al. 2017

Environmental Toxicology

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Chlorpyrifos (CPF) is one of the most widely used organophosphorus, which has spurred renewed interest. This study was conducted to investigate the protective effect of ziziphora tenuior extract against CPF-induced liver and lung toxicity. This study conducted 8-week rat sub-chronic toxicity study and then the effect of ziziphora tenuior extract in 3 different doses (40, 80, 160 mg/kg) was determined. We administrated maximum tolerated dose of CPF (6.75 mg/kg) by gavage for 8 weeks (5 times in week) to male rats. Rats were sacrificed 24 h after last dose and the biochemical analysis, which confirms involvement of oxidative stress in the pathogenesis of CPF toxicity in liver including increased in lipid peroxidation, protein carbonyl content, and ROS formation, glutathione depletion, decreased of antioxidant effect via frap oxidation and cytochrome c expulsion. In addition, pathological lesions confirm the dysfunction of the organs (liver and lung). In addition, using of ziziphora extract as an antioxidant is resulted in amelioration of oxidative stress marker in liver and lung damage. In conclusion, the current study revealed that CPF toxicity is related to oxidative stress and induction of cell death signaling and cotreatment with ziziphora extract is recommended in the routine therapy for the protection against CPF induced liver and lung tissue damage.

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Bioassay-guided isolation of vasorelaxant compounds from Ziziphora clinopodioides Lam. (Lamiaceae)

Cited by 34 publications

References 22 publications

Antihypertensive effect of piperitenone oxide on spontaneously hypertensive rat by regulating calcium balance and reducing endothelin-1 secretion

Antihypertensive effect of piperitenone oxide on spontaneously hypertensive rat by regulating calcium balance and reducing endothelin-1 secretion

Kazakh Ziziphora Species as Sources of Bioactive Substances

Protective effects of Ziziphora tenuior extract against chlorpyrifos induced liver and lung toxicity in rat: Mechanistic approaches in subchronic study

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