Bioassay-guided isolation of anti-inflammatory and antinociceptive principles from a folk remedy, Rhododendron ponticum L. leaves

Chemical Constituents of Plants from the Genus Rhododendron

“…Some insignificant inhibitory rates were obtained against TPA-induced ear edema (23.3% inhibition) and p-benzoquinone-induced writhes (20.2% inhibition). Both of the isolates 102 and 103 were found safe, neither gastric lesions or bleedings nor mortality was observed during the 24 h acute toxicity testing [6].…”

“…Both flowers and fruits of R. molle have been recorded in ancient and modern monographs as analgesics [5]. Additionally, in the traditional medicines worldwide, several other Rhododendron species, such as R. ponticum, R. chrysanthum, R. ferrugineum, R. molle, R. cinnabarium, and R. collettianum [6], have been applied against various inflammatory conditions and pain.…”

“…In Turkish traditional medicine, R. ponticum L. is used for the treatment of inflammatory diseases, and to alleviate rheumatic pain and against toothache. To identify the main bioactive principles, a bioassay-guided fractionation of an extract of R. ponticum L. leaves was performed in 2008, which resulted in the isolation of compounds 102 and 103 [6]. Compound 102 showed a potent antinociceptive activity against p-benzoquinoneinduced writhes (25.8% inhibition) and anti-inflammatory activity against carrageenan-induced hind paw edema (26.8 -29.7% inhibition), as well as TPA-induced ear edema models (32.8% inhibition).…”

Synthesis, characterization and anti-inflammatory evaluation of novel derivatives of Trolox with pharmacological alcohol and amines

“…The results were expressed as mean±SD and statistical analysis was performed by means of student's t-test or by one-way analysis of variance followed by the Dunnett's test for multiple comparisons of unpaired data. Statistically, a p value of less than 0.05 was considered to be significant and a p value of less than 0.01 was considered to be very significant [9,10].…”

Ecological and geographical variation of morphometric parameters and flavonoid composition of Rhododendron parvifolium

“…Гиперозид, авикулярин и кверцетин относятся к константным веществам рода Rhododendron (Belousov et al, 1998). В некоторых видах были обнаружены также 3-О-ксилозид кверцетина (Dai, Yu, 2005), изокверцитрин (Erdemoglu et al, 2008), рутин (Swaroop et al, 2005;Prakash et al, 2007;Komarova et al, 2009;Li et al, 2014), лютеолин и изорамнетин (Zhao et al, 2008; Рис. 1.…”