Bioassay-guided isolation of a vasorelaxant active compound from Kaempferia galanga L.

Othman, Rozana; Ibrahim, Halijah; Mohd, Mustafa Ali; Mustafa, Ali; Awang, Khalijah

doi:10.1016/j.phymed.2004.07.004

Cited by 75 publications

(61 citation statements)

References 5 publications

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“…[8][9][10] However, a closer examination of the chemical structure of NG-3b shows a carbazole-like skeleton which has been found in studies to be important biogenetic precursors in phytochemistry. 12 Furthermore, this compound has been obtained from Lepidium sativum using GC-MS, and FTIR spectrometry.…”

Section: Resultsmentioning

confidence: 97%

“…Furthermore, these data were found to be consistent with those reported in the literature. [8][9][10][11] Consequently, NG-1b andNG-3b have been revealed to be ethyl cinnamate (cinnamic acid, ethyl ester) and 9-oximino-2, 7-diethoxy fluorene (2, 7-diethoxy-9H-fluoren-9-one oxime) respectively as presented in 1igures1 and 2. Due to the nature of the matrices, many fragmented ions appeared in the mass spectra of the compounds.…”

Section: Antimicrobial Screeningmentioning

confidence: 99%

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Isolation of ethyl cinnamate and a subtituted fluorene from Pycnanthus angolensis (Welw.) Warb.

Oladimeji¹,

Onu²

2017

ECB

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Before now, two compounds namely, 3-ethoxy-3,7-dimethyl-1,6-octadiene (ethyl linalool) and 1,2-benzenedicarboxylic acid diethyl ester (diethyl phthalate) have been isolated from the ethyl acetate fraction of Pycnanthus angolensis by column chromatography. In this study, the preparative thin-layer chromatography (p-TLC) of two previously obtained residues was carried out. The chemical and biological properties of the compounds obtained there from were evaluated. This exercise led to two isolates (NG-1b and NG-3b) whose identities have been revealed to be ethyl cinnamate (cinnamic acid, ethyl ester) and 9-oximino-2,7-diethoxy fluorene (2,7-diethoxy-9H-fluoren-9-one oxime) respectively using the MS and IR spectral techniques. The compounds were surprisingly strongly bacteriostatic against Escherichia coli but recorded no activity against Staphylococcus aureus and Candida albicans.

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Section: Resultsmentioning

confidence: 97%

Section: Antimicrobial Screeningmentioning

confidence: 99%

Isolation of ethyl cinnamate and a subtituted fluorene from Pycnanthus angolensis (Welw.) Warb.

Oladimeji¹,

Onu²

2017

ECB

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“…Ethyl-cinnamate and (Sutthanont et al, 2010). ethyl-para-methoxycinnamate are found to be the most vital constituents in the dichloromethane (Othman et al, 2006), hexane (Yu et al, 2000) and methanol extracts (Huang et al, 2008). About 98.98% of essential oil constituents have been isolated and identified with only 1.11% constituents that are still unknown (Sutthanont et al, 2010).…”

Section: Chemistrymentioning

confidence: 99%

“…The most abundant essential oil constituents include propanoic acid, pentadecane, ethyl-pmethoxycinnamate. Other constituents include 1,8-cineol, undecanone, isopropyl cinnamate, dicyclohexylpropanedinitrile, dipentene dioxide, 9-hydroxy, 2-nonanone, 2,7-octadiene-1-yl acetate, ethyl cyclohexyl acetate, cis-11-tetradecenyl acetate, 2-heptadecanone, 4-methyl isopulegone, camphidine, trans,trans-octa-2, 4-dienyl acetate, 10-undecyn-1-ol, 3,7-dimethoxycoumarin, delta-3-carene, alpha pinene, camphene, borneol, cymene, alpha terpineol, alpha gurjunene, germacrenes, cadinenes, caryophyllenes, luteolin and apigenin (Koh, 2009;Mustafa et al, 2010;Othman et al, 2006;Sutthanont et al, 2010).…”

Section: Chemistrymentioning

confidence: 99%

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Phytochemistry and medicinal properties of Kaempferia galanga L. (Zingiberaceae) extracts

Umar¹

2011

Afr. J. Pharm. Pharmacol.

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Kaempferia galanga L. (KG), commonly known as cekor is one of those precious medicinal herbs ofZingiberaceas that are still included in un-utilized herbs inspite of the variety of useful pharmacological properties it possesses. Extracts of KG have anti-inflammatory, analgesic, nematicidal, mosquito repellent, larvicidal, vasorelaxant, sedative, antineoplastic, antimicrobial, anti-oxidant, antiallergic and wound healing properties. Here, we have reviewed all the reported pharmacological properties of this valuable herb with an intention to highlight the effectiveness and potentials of this herb. Ethyl-pmethoxycinnamate and ethyl-cinnamate are found to be the most vital constituents responsible for most of these pharmacological properties. Antinociceptive effect of KG extracts is comparable with that of aspirin whereas its nematicidal effect is even more potent than Carbofuran and metham sodium.

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New Insights into the Chemical Composition, Pro‐Inflammatory Cytokine Inhibition Profile of Davana (Artemisia pallens Wall. ex DC.) Essential Oil and cis‐Davanone in Primary Macrophage Cells

Singh

Bhatt

Singh

et al. 2021

Chemistry & Biodiversity

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Artemisia pallens Wall. ex DC., popularly known as davana, has gained considerable attention because of its unique fragrance, high economic value, and pharmacological properties. The compositional complexity of davana essential oil (DO) has been a challenge for quality control. In this study, the chemical profile of DO was developed using polarity‐based fractionation and a combination of gas chromatographic (GC‐FID), hyphenated chromatographic (GC/MS), and spectroscopic (Fourier‐Transform Infra‐Red, 1D, 2D‐Nuclear Magnetic Resonance) techniques. The analysis led to the identification of ninety‐nine compounds. Major components of the DO were cis‐davanone (D3, 53.0 %), bicyclogermacrene (6.9 %), trans‐ethyl cinnamate (4.9 %), davana ether isomer (3.4 %), spathulenol (2.8 %), cis‐hydroxy davanone (2.4 %), and trans‐davanone (2.1 %). The study led to identifying several co‐eluting novel minor components, which could help determine the authenticity of DO. The rigorous column‐chromatography led to the isolation of five compounds. Among these, bicyclogermacrene, trans‐ethyl cinnamate, and spathulenol were isolated and characterized by spectroscopic methods for the first time from DO. Pharmacological profile revealed that the treatment of DO and D3 inhibited the production of pro‐inflammatory cytokines (TNF‐α, IL‐6) induced by lipopolysaccharide (LPS) in primary macrophages without any cytotoxic effect after administration of their effective concentrations. The result of this study indicates the suitability of DO and D3 for further investigation for the treatment of chronic skin inflammatory conditions.

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Bioassay-guided isolation of a vasorelaxant active compound from Kaempferia galanga L.

Cited by 75 publications

References 5 publications

Isolation of ethyl cinnamate and a subtituted fluorene from Pycnanthus angolensis (Welw.) Warb.

Isolation of ethyl cinnamate and a subtituted fluorene from Pycnanthus angolensis (Welw.) Warb.

Phytochemistry and medicinal properties of Kaempferia galanga L. (Zingiberaceae) extracts

New Insights into the Chemical Composition, Pro‐Inflammatory Cytokine Inhibition Profile of Davana (Artemisia pallens Wall. ex DC.) Essential Oil and cis‐Davanone in Primary Macrophage Cells

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