effect.Pycnanthus angolensis (Welw.) Warb. (Family; Myristiceae) leaves were extracted cold with 50 % ethanol and the obtained aqueous crude extract partitioned with ethyl acetate. Furthermore, the ethyl acetate fraction was subjected to silica gel column chromatography and the isolated chemical compounds tested for antimicrobial activity against Staphylococcus aureus, Escherichia coli and Candida albicans. The identities of two isolates have been revealed to be 3-ethoxy-3,7-dimethyl-1, 6-octadiene (ethyl linalool) and diethyl phthalate (1,2-benzenedicarboxylic acid diethyl ester) using the MS and IR spectral techniques. Both compounds showed strong bacteriostatic action against E. coli but were inactive against S. aureus and C. albicans.
Before now, two compounds namely, 3-ethoxy-3,7-dimethyl-1,6-octadiene (ethyl linalool) and 1,2-benzenedicarboxylic acid diethyl ester (diethyl phthalate) have been isolated from the ethyl acetate fraction of Pycnanthus angolensis by column chromatography. In this study, the preparative thin-layer chromatography (p-TLC) of two previously obtained residues was carried out. The chemical and biological properties of the compounds obtained there from were evaluated. This exercise led to two isolates (NG-1b and NG-3b) whose identities have been revealed to be ethyl cinnamate (cinnamic acid, ethyl ester) and 9-oximino-2,7-diethoxy fluorene (2,7-diethoxy-9H-fluoren-9-one oxime) respectively using the MS and IR spectral techniques. The compounds were surprisingly strongly bacteriostatic against Escherichia coli but recorded no activity against Staphylococcus aureus and Candida albicans.
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