Bioassay-guided isolation and UHPLC-DAD-ESI-MS/MS quantification of potential anti-inflammatory phenolic compounds from flowers of Inula montana L

Garayev, Elnur; Giorgio, Carole Di; Herbette, Gaëtan; Mabrouki, F; Chiffolleau, Philippe; Roux, David G.; Sallanon, Huguette; Ollivier, Évelyne; Élias, Riad; Baghdikian, Béatrice

doi:10.1016/j.jep.2018.08.005

Cited by 29 publications

(18 citation statements)

References 21 publications

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“…Bioassay-guided fractionation is a well-established approach for untargeted, but focused screening of active compounds in complex matrices. [44][45][46][47][48] From the identified compounds (Table S2 †), p-cymene, cinnamyl alcohol, cinnamic acid and cinnamalde-hyde are present in Cinnamomum verum extract, with the latter as major active principle. 15,24,49,50 To the best of our knowledge, the other compounds shown in Table S2 † were not reported to be present in cinnamon extract so far.…”

Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

et al. 2018

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Section: Discussionmentioning

confidence: 99%

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

et al. 2018

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“…Several compounds from Inula montana L. possessed promising anti-inflammatory activity through inhibition of NO production in murine macrophages RAW 264.7 cell line, jaceoside ( 14 ) (Figure 2) being the compound most active with IC 50 of 0.34 ± 0.01 μM, being several times better than the positive control drug dexamethasone (IC 50 of 3.89 ± 0.94 μM) [63].…”

Section: Secondary Metabolites From Inula Species Against Oxidativmentioning

confidence: 99%

Inula L. Secondary Metabolites against Oxidative Stress-Related Human Diseases

Tavares

Seca

2019

Antioxidants

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An imbalance in the production of reactive oxygen species in the body can cause an increase of oxidative stress that leads to oxidative damage to cells and tissues, which culminates in the development or aggravation of some chronic diseases, such as inflammation, diabetes mellitus, cancer, cardiovascular disease, and obesity. Secondary metabolites from Inula species can play an important role in the prevention and treatment of the oxidative stress-related diseases mentioned above. The databases Scopus, PubMed, and Web of Science and the combining terms Inula, antioxidant and secondary metabolites were used in the research for this review. More than 120 articles are reviewed, highlighting the most active compounds with special emphasis on the elucidation of their antioxidative-stress mechanism of action, which increases the knowledge about their potential in the fight against inflammation, cancer, neurodegeneration, and diabetes. Alantolactone is the most polyvalent compound, reporting interesting EC50 values for several bioactivities, while 1-O-acetylbritannilactone can be pointed out as a promising lead compound for the development of analogues with interesting properties. The Inula genus is a good bet as source of structurally diverse compounds with antioxidant activity that can act via different mechanisms to fight several oxidative stress-related human diseases, being useful for development of new drugs.

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“…It has been also reported that different extracts from I. helenium roots contained 5‐CQA (35.5–47 mg/100 g DW) and dicaffeoylquinic acid (60.8–73.4 mg/100 g DW) . The flowers of I. montana contained between 0.39–0.41 % of mono‐ and 0.92–14.41 % of dicaffeoylquinic acids . 1,5‐DCQA was the main component of I. crithmoides roots (0.035 % w/w) .…”

Section: Resultsmentioning

confidence: 91%

“…Plants belonging to this genus have shown to possess various biological activities–anti‐inflammatory, antitumor, antibacterial, antitussive, antiproliferative, antioxidant, antidiabetic and hepatoprotective, etc., which were attributed to the abundance of bioactive components mainly sesquiterpene lactones, phenolic acids, and flavonoids . Chlorogenic acid and dicaffeoyl esters of quinic acid have been also reported in some Inula species …”

Section: Introductionmentioning

confidence: 99%

Caffeoylquinic Acids, Cytotoxic, Antioxidant, Acetylcholinesterase and Tyrosinase Enzyme Inhibitory Activities of Six Inula Species from Bulgaria

Трендафилова

Ivanova

Rangelov

et al. 2020

Chemistry & Biodiversity

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Chlorogenic (5-CQA), 1,5-, 3,5-, 4,5-and 3,4-dicaffeoylquinic (DCQA) acids were identified and quantified in the methanol extracts of Inula oculus-christi L., I. bifrons L., I. aschersoniana JANKA var. aschersoniana, I. ensifolia L., I. conyza (GRIESS.) DC. and I. germanica L. by HPLC analysis. The amount of 5-CQA varied from 5.48 to 28.44 mg/g DE and the highest content was detected in I. ensifolia. 1,5-DCQA (4.05-55.25 mg/g DE) was the most abundant dicaffeoyl ester of quinic acid followed by 3,5-DCQA, 4,5-DCQA and 3,4-DCQA. The extract of I. ensifolia showed the highest total phenolic content (119.92 � 0.95 mg GAE/g DE) and exhibited the strongest DPPH radical scavenging activity (69.41 � 0.55 %). I. bifrons extract was found to be the most active sample against ABTS * + (TEAC 0.257 � 0.012 mg/mL) and the best tyrosinase inhibitor. The studied extracts demonstrated a low inhibitory effect towards acetylcholinesterase and possessed low cytotoxicity in concentration range from 10 to 300 μg/mL toward non-cancer (MDCK II) and cancer (A 549) cells. Figure 2. HPLC chromatograms of the studied extracts and standard mixture.[a] Results are presented as mean � SD from three replicates (n = 3). Means in the columns with the same letter are not significantly different from each other (p > 0.05) (t-test).

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Bioassay-guided isolation and UHPLC-DAD-ESI-MS/MS quantification of potential anti-inflammatory phenolic compounds from flowers of Inula montana L

Cited by 29 publications

References 21 publications

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

Anti-inflammatory effects of cinnamon extract and identification of active compounds influencing the TLR2 and TLR4 signaling pathways

Inula L. Secondary Metabolites against Oxidative Stress-Related Human Diseases

Caffeoylquinic Acids, Cytotoxic, Antioxidant, Acetylcholinesterase and Tyrosinase Enzyme Inhibitory Activities of Six Inula Species from Bulgaria

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