Bioapplications for Molecularly Imprinted Polymers

Schirhagl, Romana

doi:10.1021/ac401251j

Cited by 321 publications

(176 citation statements)

References 175 publications

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“…Most commonly, the dominant interaction is hydrogen bonding, which often occurs between methacrylic acid (MAA) groups and primary amines in nonpolar solvents. 12 Recently, noncovalent imprinting has become the most popular and general synthesis strategy due to the simplicity of operation and rapidity of binding and removal. However, noncovalent imprinting is sensitive to even slight disruption of the interactions holding the complex together (for example, the presence of water), and it is therefore not very robust.…”

Section: Fundamentals Of Mipsmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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a Molecular imprinting technology (MIT), often described as a method of making a molecular lock to match a molecular key, is a technique for the creation of molecularly imprinted polymers (MIPs) with tailor-made binding sites complementary to the template molecules in shape, size and functional groups. Owing to their unique features of structure predictability, recognition specificity and application universality, MIPs have found a wide range of applications in various fields. Herein, we propose to comprehensively review the recent advances in molecular imprinting including versatile perspectives and applications, concerning novel preparation technologies and strategies of MIT, and highlight the applications of MIPs. The fundamentals of MIPs involving essential elements, preparation procedures and characterization methods are briefly outlined.Smart MIT for MIPs is especially highlighted including ingenious MIT (surface imprinting, nanoimprinting, etc.), special strategies of MIT (dummy imprinting, segment imprinting, etc.) and stimuli-responsive MIT (single/dual/ multi-responsive technology). By virtue of smart MIT, new formatted MIPs gain popularity for versatile applications, including sample pretreatment/chromatographic separation (solid phase extraction, monolithic column chromatography, etc.) and chemical/biological sensing (electrochemical sensing, fluorescence sensing, etc.). Finally, we propose the remaining challenges and future perspectives to accelerate the development of MIT, and to utilize it for further developing versatile MIPs with a wide range of applications (650 references).

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Section: Fundamentals Of Mipsmentioning

confidence: 99%

Molecular imprinting: perspectives and applications

et al. 2016

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“…Among several receptors, synthetic antibodies based on MIPs have placed themselves as highly efficient recognition elements for a wide range of bio-analytes [50][51][52]. Molecular imprinting is a straightforward way to introduce the target analyte or a closely related molecule as the template in polymer matrix to develop highly specific affinity centers [53].…”

Section: Synthetic Antibodies: Molecularly Imprinted Polymers For Qcmmentioning

confidence: 99%

Gravimetric Viral Diagnostics: QCM Based Biosensors for Early Detection of Viruses

et al. 2017

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Viruses are pathogenic microorganisms that can inhabit and replicate in human bodies causing a number of widespread infectious diseases such as influenza, gastroenteritis, hepatitis, meningitis, pneumonia, acquired immune deficiency syndrome (AIDS) etc. A majority of these viral diseases are contagious and can spread from infected to healthy human beings. The most important step in the treatment of these contagious diseases and to prevent their unwanted spread is to timely detect the disease-causing viruses. Gravimetric viral diagnostics based on quartz crystal microbalance (QCM) transducers and natural or synthetic receptors are miniaturized sensing platforms that can selectively recognize and quantify harmful virus species. Herein, a review of the label-free QCM virus sensors for clinical diagnostics and point of care (POC) applications is presented with major emphasis on the nature and performance of different receptors ranging from the natural or synthetic antibodies to selective macromolecular materials such as DNA and aptamers. A performance comparison of different receptors is provided and their limitations are discussed.

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“…Soft, porous materials like hydrogels and cryogels with various surface modifications have been utilized and recently reviewed. 11,[85][86][87] Here, we discuss their applications in microfluidic systems.…”

Section: Analysis Of Subcellular and Larger Structuresmentioning

confidence: 99%

Advances in monoliths and related porous materials for microfluidics

2016

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In recent years, the use of monolithic porous polymers has seen significant growth. These materials present a highly useful support for various analytical and biochemical applications. Since their introduction, various approaches have been introduced to produce monoliths in a broad range of materials. Simple preparation has enabled their easy implementation in microchannels, extending the range of applications where microfluidics can be successfully utilized. This review summarizes progress regarding monoliths and related porous materials in the field of microfluidics between 2010 and 2015. Recent developments in monolith preparation, solid-phase extraction, separations, and catalysis are critically discussed. Finally, a brief overview of the use of these porous materials for analysis of subcellular and larger structures is given.

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Bioapplications for Molecularly Imprinted Polymers

Cited by 321 publications

References 175 publications

Molecular imprinting: perspectives and applications

Molecular imprinting: perspectives and applications

Gravimetric Viral Diagnostics: QCM Based Biosensors for Early Detection of Viruses

Advances in monoliths and related porous materials for microfluidics

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