Bioadhesive HPMC Gel Containing Gelatin Nanoparticles for Intravaginal Delivery of Tenofovir

Manna, Sreejan; Lakshmi, Uppadi Swathi; Racharla, Manasa; Sinha, Pratyusha; Kanthal, Lakshmi Kanta; Kumar, Sanjay

doi:10.7324/japs.2016.60804

Cited by 25 publications

(14 citation statements)

References 23 publications

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“…The spread diameter (Φ) was measured after 1 min. [29][30][31][32] The measurements were done 3 times, and the results were represented as a mean value ± SD.…”

mentioning

confidence: 99%

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Andonova¹,

Peneva²,

Georgiev³

et al. 2017

IJN

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The purpose of the study was to investigate the stability and biopharmaceutical characteristics of ketoprofen, loaded in polymeric carriers, which were included into a bigel in a semisolid dosage form. The polymer carriers with in situ-included ketoprofen were obtained by emulsifier-free emulsion polymerization of the monomers in aqueous medium or a solution of the polymers used. The morphological characteristics of the carriers, the in vitro release and the photochemical stability of ketoprofen were evaluated. The model with optimal characteristics was included in a bigel formulation. The bigel was characterized in terms of pH, rheological behavior, spreadability, and in vitro drug release. Acute skin toxicity, antinociceptive activity, anti-inflammatory activity, and antihyperalgesic effects of the prepared bigel with ketoprofen-loaded polymer carrier were evaluated. The carriers of ketoprofen were characterized by a high yield and drug loading. The particle size distribution varied widely according to the polymer used, and a sustained release was provided for up to 6 hours. The polymer mixture poly(vinyl acetate) and hydroxypropyl cellulose as a drug carrier, alone or included in the bigel composition, improved the photostability of the drug compared with unprotected ketoprofen. The bigel with ketoprofen-loaded particles provided sustained release of the drug and had optimal rheological parameters. In vivo experiments on the bigel showed no skin inflammation or irritation. Four hours after its application, a well-defined analgesic, anti-inflammatory, and antihyperalgesic effect was registered. The polymer mixture of poly(vinyl acetate) and hydroxypropyl cellulose as a carrier of ketoprofen and the bigel in which it was included provided an enhanced photostability and sustained drug release.

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“…The spread diameter (Φ) was measured after 1 min. [29][30][31][32] The measurements were done 3 times, and the results were represented as a mean value ± SD.…”

mentioning

confidence: 99%

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Andonova¹,

Peneva²,

Georgiev³

et al. 2017

IJN

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“…From the data attained, it can be said that an increase in HPMC concentration results in a less spreadability of the prepared in situ gelling liquid suppository formulations. A high viscosity and bioadhesive property of the HPMC K15M could be responsible for this decline in the spreadability [56] .…”

Section: Resultsmentioning

confidence: 99%

An Innovative Mucoadhesive Thermosensitive In situ Gelling Liquid Suppository of Metoclopramide Hydrocloride for Treatment of Nausea and Vomiting Associated with Diseases

Salman¹,

Alhamdany²,

Yousif³

2020

pharmaceutical-sciences

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“…Tenofovir vaginal gel has been investigated within the prevention of HIV. Gelatin nanoparticles of Tenofovir were ready by 2 step desolvation methodology HPMC K15M was used as a bio adhesive compound in addition as a gelling agent [150].…”

Section: Vaginal Drug Deliverymentioning

confidence: 99%

Overview of nanogel and its applications

Ghaywat¹,

Mate²,

Parsutkar³

et al. 2021

GSC Biol. and Pharm. Sci.

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Nanogel have emerged as a versatile drug delivery system for encapsulation of guest molecules. A nanoparticle which is composed of hydrophilic polymer network known as Nanogel having range from 100-200nm. Nanogel have swellable and degradation properties with high drug loading capacity, high stability, sustained and targetable manner, large surface area. Therefore, nanogel are more productive than conventional and micro-sized delivery. In recent year in the field of biotechnology nanogel were prominently used to deal with genetics, enzyme immobilization and protein synthesis. Moreover, it has productive asset for the development of novel therapeutic system in medicine. These are soft materials capable of holding small molecular biomacromolecules, therapeutics, and inorganic nanoparticles within their crosslinked networks, which allows them to find applications for therapy as well as imaging of a variety of disease conditions. These properties not only enhance the functionality of the carrier system but also help in overcoming many challenges associated with the delivery of cargo molecules. This review aims to highlight the distinct and unique capabilities of nanogels as carrier system, Synthesis of nanogels, Types of Physical and chemical crosslinked nanogels, Stimuli responsive behavior, In vivo behavior, Therapeutic drug carrier, marketed formulation of Nanogels and the last part of review summarizes the applications of nanogels in various diseases. Transdermal drug delivery, diabetes, anti-inflammatory, vaginal drug delivery, neurodegenerative diseases, ocular dieses, autoimmune disease, and anticancer treatment for specially targeting the cancer cells, thereby reducing uptake into healthy cells. This nanogel drug delivery is a phenomenal system, and further depth study is required to explore their interaction at cellular and molecular levels and minimize the challenges.

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Bioadhesive HPMC Gel Containing Gelatin Nanoparticles for Intravaginal Delivery of Tenofovir

Cited by 25 publications

References 23 publications

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

Ketoprofen-loaded polymer carriers in bigel formulation: an approach to enhancing drug photostability in topical application forms

An Innovative Mucoadhesive Thermosensitive In situ Gelling Liquid Suppository of Metoclopramide Hydrocloride for Treatment of Nausea and Vomiting Associated with Diseases

Overview of nanogel and its applications

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