Bioactivity of Essential Oils and Their Components

Koroch, Adolfina R.; Juliani, H. Rodolfo; Zygadlo, Julio Alberto

doi:10.1007/978-3-540-49339-6_5

Cited by 113 publications

(92 citation statements)

References 349 publications

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“…Usually, major compounds are the ones responsible for the antifungal activity of the essential oils. However, some studies show that minor components may have a crucial role in the biological activity of the oils (Koroch et al, 2007). Our results seem to indicate that the activity of L. viridis essential oil is mainly due to the presence of apinene in the oil.…”

Section: Antifungal Activity Of the Essential Oilssupporting

confidence: 45%

Chemical composition and antifungal activity of the essential oils of Lavandula viridis L'Hér.

Zuzarte

Gonçalves

Cavaleiro

et al. 2011

Journal of Medical Microbiology

120

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In the present work we report for what we believe to be the first time the antifungal activity and mechanism of action of the essential oils of Lavandula viridis from Portugal. The essential oils were isolated by hydrodistillation and analysed by GC and GC/MS. The MIC and the minimal lethal concentration (MLC) of the essential oil and its major compounds were determined against several pathogenic fungi. The influence of subinhibitory concentrations of the essential oil on the dimorphic transition in Candida albicans was also studied, as well as propidium iodide and FUN-1 staining of Candida albicans cells by flow cytometry following short treatments with the essential oil. The oils were characterized by a high content of oxygen-containing monoterpenes, with 1,8-cineole being the main constituent. Monoterpene hydrocarbons were present at lower concentrations. According to the determined MIC and MLC values, the dermatophytes and Cryptococcus neoformans were the most sensitive fungi (MIC and MLC values ranging from 0.32 to 0.64 ml ml "1 ), followed by Candida species (at 0.64-2.5 ml ml "1 ). For most of these strains, MICs were equivalent to MLCs, indicating a fungicidal effect of the essential oil. The oil was further shown to completely inhibit filamentation in Candida albicans at concentrations well below the respective MICs (as low as MIC/16). Flow cytometry results suggested a mechanism of action ultimately leading to cytoplasmic membrane disruption and cell death. Our results show that L. viridis essential oils may be useful in the clinical treatment of fungal diseases, particularly dermatophytosis and candidosis, although clinical trials are required to evaluate the practical relevance of our in vitro research.

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Section: Antifungal Activity Of the Essential Oilssupporting

confidence: 45%

Chemical composition and antifungal activity of the essential oils of Lavandula viridis L'Hér.

Zuzarte

Gonçalves

Cavaleiro

et al. 2011

Journal of Medical Microbiology

120

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“…Identification of the biological and pharmacological activities of flavor compounds has been gathering momentum in recent years. The commercialization of plant volatiles is also focused on their bioactivities, including anti-microbial, antiviral, anti-oxidative, analgesic, digestive, anti-carcinogenic, semiochemical and other activities (Koroch et al, 2007). Aromatherapy is a form of complementary or alternative medicine that uses essential oils and other scented plant compounds for therapeutic purposes, affecting a person's mood or health (Kiecolt-Glaser et al, 2008).…”

Section: Possible Uses Of Flavor Moleculesmentioning

confidence: 99%

Biosynthesis of plant‐derived flavor compounds

Schwab¹,

Davidovich‐Rikanati²,

Lewinsohn³

2008

The Plant Journal

944

704

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SummaryPlants have the capacity to synthesize, accumulate and emit volatiles that may act as aroma and flavor molecules due to interactions with human receptors. These low-molecular-weight substances derived from the fatty acid, amino acid and carbohydrate pools constitute a heterogenous group of molecules with saturated and unsaturated, straight-chain, branched-chain and cyclic structures bearing various functional groups (e.g. alcohols, aldehydes, ketones, esters and ethers) and also nitrogen and sulfur. They are commercially important for the food, pharmaceutical, agricultural and chemical industries as flavorants, drugs, pesticides and industrial feedstocks. Due to the low abundance of the volatiles in their plant sources, many of the natural products had been replaced by their synthetic analogues by the end of the last century. However, the foreseeable shortage of the crude oil that is the source for many of the artifical flavors and fragrances has prompted recent interest in understanding the formation of these compounds and engineering their biosynthesis. Although many of the volatile constituents of flavors and aromas have been identified, many of the enzymes and genes involved in their biosynthesis are still not known. However, modification of flavor by genetic engineering is dependent on the knowledge and availability of genes that encode enzymes of key reactions that influence or divert the biosynthetic pathways of plant-derived volatiles. Major progress has resulted from the use of molecular and biochemical techniques, and a large number of genes encoding enzymes of volatile biosynthesis have recently been reported.

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“…Sin embargo los aceites esenciales ensayados no han mostrado mayor actividad a mayor contenido en compuestos oxigenados, por lo que la compleja mezcla de compuestos presentes en cada aceite esencial condiciona su actividad. La bioactividad de los aceites esenciales, normalmente atribuida a los compuestos mayoritarios, también puede ser debida a los efectos combinados de diversos componentes minoritarios o a los efectos sinérgicos de algunos compuestos (Barney et al, 2005;Koroch et al, 2007).…”

Section: Discussionunclassified

Fitotoxicidad De Aceites Esenciales Y Extractos Acuosos De Plantas Mediterráneas Para El Control De Arvenses

Sancho¹,

Mercedes²

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Bioactivity of Essential Oils and Their Components

Cited by 113 publications

References 349 publications

Chemical composition and antifungal activity of the essential oils of Lavandula viridis L'Hér.

Chemical composition and antifungal activity of the essential oils of Lavandula viridis L'Hér.

Biosynthesis of plant‐derived flavor compounds

Fitotoxicidad De Aceites Esenciales Y Extractos Acuosos De Plantas Mediterráneas Para El Control De Arvenses

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