Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb

Sreelatha, T.; Hymavathi, A.; Murthy, Joish Madhusudhana; Rani, Poonam; Rao, J. Madhusudana; Babu, K. Suresh

doi:10.1016/j.bmcl.2010.02.107

Cited by 23 publications

(6 citation statements)

References 31 publications

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“…naphthoquinones and naphthoquinone dimers isoshinanolone (LC 50 = 1.26 µg/mL), plumbagin (LC 50 = 5.43 µg/mL), 3-O-methyldroserone (LC 50 = 31.5 µg/mL), 6-hydroxyplumbagin (LC 50 = 13.6 µg/mL), maritinone (LC 50 = 40.7 µg/mL), and chitranane (LC 50 = 31.2 µg/mL) were isolated and found to be larvicidal to Ae. aegypti [66]. In other work, Plumbago dawei Rolfe ethyl acetate, P. stenophylla Wilmot-Dear chloroform, and P. zeylanica L. hexane and chloroform extracts of root barks exhibited strong larvicidal activity against An.…”

Section: Mosquito Larvicidesmentioning

confidence: 83%

Plant Extracts, Isolated Phytochemicals, and Plant-Derived Agents Which Are Lethal to Arthropod Vectors of Human Tropical Diseases - A Review

et al. 2011

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The recent scientific literature on plant-derived agents with potential or effective use in the control of the arthropod vectors of human tropical diseases is reviewed. Arthropod-borne tropical diseases include: amebiasis, Chagas disease (American trypanosomiasis), cholera, cryptosporidiosis, dengue (hemorrhagic fever), epidemic typhus (Brill-Zinsser disease), filariasis (elephantiasis), giardia (giardiasis), human African trypanosomiasis (sleeping sickness), isosporiasis, leishmaniasis, Lyme disease (lyme borreliosis), malaria, onchocerciasis, plague, recurrent fever, sarcocystosis, scabies (mites as causal agents), spotted fever, toxoplasmosis, West Nile fever, and yellow fever. Thus, coverage was given to work describing plant-derived extracts, essential oils (EOs), and isolated chemicals with toxic or noxious effects on filth bugs (mechanical vectors), such as common houseflies (Musca domestica Linnaeus), American and German cockroaches (Periplaneta americana Linnaeus, Blatella germanica Linnaeus), and oriental latrine/blowflies (Chrysomya megacephala Fabricius) as well as biting, blood-sucking arthropods such as blackflies (Simulium Latreille spp.), fleas (Xenopsylla cheopis Rothschild), kissing bugs (Rhodnius Stål spp., Triatoma infestans Klug), body and head lice (Pediculus humanus humanus Linnaeus, P. humanus capitis De Geer), mosquitoes (Aedes Meigen, Anopheles Meigen, Culex L., and Ochlerotatus Lynch Arribálzaga spp.), sandflies (Lutzomyia longipalpis Lutz & Neiva, Phlebotomus Loew spp.), scabies mites (Sarcoptes scabiei De Geer, S. scabiei var hominis, S. scabiei var canis, S. scabiei var suis), and ticks (Ixodes Latreille, Amblyomma Koch, Dermacentor Koch, and Rhipicephalus Koch spp.). Examples of plant extracts, EOs, and isolated chemicals exhibiting noxious or toxic activity comparable or superior to the synthetic control agents of choice (pyrethroids, organophosphorous compounds, etc.) are provided in the text for many arthropod vectors of tropical diseases.

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Section: Mosquito Larvicidesmentioning

confidence: 83%

Plant Extracts, Isolated Phytochemicals, and Plant-Derived Agents Which Are Lethal to Arthropod Vectors of Human Tropical Diseases - A Review

et al. 2011

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“…ZINC000044417732 (chitranone) has been isolated from the roots of Plumbago zeylanica [ 175 , 176 ] and P. capensis [ 177 ], and stem bark and fruits of Diospyros maritima [ 178 , 179 , 180 ] and D. kaki [ 180 ]. Chitranone has been previously reported to be cytotoxic against four cancer cell lines including human oral epidermoid carcinoma (KB), human lung cancer (Lu1), hormone-dependent human prostate cancer (LNCaP), and human umbilical vein endothelial cells (HUVEC) at EC 50 values of 0.3, 1.1, 2.2, and 2.1 μg/mL, respectively [ 178 ].…”

Section: Resultsmentioning

confidence: 99%

Molecular Docking and Dynamics Simulation Studies Predict Potential Anti-ADAR2 Inhibitors: Implications for the Treatment of Cancer, Neurological, Immunological and Infectious Diseases

Broni

Striegel

Ashley

et al. 2023

IJMS

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Altered RNA editing has been linked to several neurodevelopmental disorders, including autism spectrum disorder (ASD) and intellectual disability, in addition to depression, schizophrenia, some cancers, viral infections and autoimmune disorders. The human ADAR2 is a potential therapeutic target for managing these various disorders due to its crucial role in adenosine to inosine editing. This study applied consensus scoring to rank potential ADAR2 inhibitors after performing molecular docking with AutoDock Vina and Glide (Maestro), using a library of 35,161 compounds obtained from traditional Chinese medicine. A total of 47 compounds were predicted to be good binders of the human ADAR2 and had insignificant toxicity concerns. Molecular dynamics (MD) simulations, including the molecular mechanics Poisson–Boltzmann surface area (MM/PBSA) procedure, also emphasized the binding of the shortlisted compounds. The potential compounds had plausible binding free energies ranging from −81.304 to −1068.26 kJ/mol from the MM/PBSA calculations. ZINC000085511995, a naphthoquinone had more negative binding free energy (−1068.26 kJ/mol) than inositol hexakisphosphate (IHP) [−873.873 kJ/mol], an agonist and a strong binder of ADAR2. The potential displacement of IHP by ZINC000085511995 in the IHP binding site of ADAR2 could be explored for possible deactivation of ADAR2. Bayesian-based biological activity prediction corroborates the neuropharmacological, antineoplastic and antiviral activity of the potential lead compounds. All the potential lead compounds, except ZINC000014612330 and ZINC000013462928, were predicted to be inhibitors of various deaminases. The potential lead compounds also had probability of activity (Pa) > 0.442 and probability of inactivity (Pi) < 0.116 values for treating acute neurologic disorders, except for ZINC000085996580 and ZINC000013462928. Pursuing these compounds for their anti-ADAR2 activities holds a promising future, especially against neurological disorders, some cancers and viral infections caused by RNA viruses. Molecular interaction, hydrogen bond and per-residue decomposition analyses predicted Arg400, Arg401, Lys519, Trp687, Glu689, and Lys690 as hot-spot residues in the ADAR2 IHP binding site. Most of the top compounds were observed to have naphthoquinone, indole, furanocoumarin or benzofuran moieties. Serotonin and tryptophan, which are beneficial in digestive regulation, improving sleep cycle and mood, are indole derivatives. These chemical series may have the potential to treat neurological disorders, prion diseases, some cancers, specific viral infections, metabolic disorders and eating disorders through the disruption of ADAR2 pathways. A total of nine potential lead compounds were shortlisted as plausible modulators of ADAR2.

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“…Based on their spectroscopic features, compounds 2 – 5 were identified (Supporting Information) as trans -isoshinanolone ( 2 ), cis -isoshinanolone ( 3 ) [15,16,17,18,19,20,21,22,23,24,25], plumbagin ( 4 ) [26,27,28,29,30], and 3,3′-biplumbagin ( 5 ) [14,17,25]. Of the five isolated compounds 1 , 4 , and 5 possess rigid planar 1,4-naphthoquinone skeletons whereas the saturated hydroxyl-cyclohexanone ring of 2 and 3 allow some conformational flexibility.…”

Section: Resultsmentioning

confidence: 99%

Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis

et al. 2016

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As part of our search for natural products having antioxidant and anticancer properties, the phytochemical investigation of Diospyros shimbaensis (Ebenaceae), a plant belonging to a genus widely used in East African traditional medicine, was carried out. From its stem and root barks the new naphthoquinone 8,8′-oxo-biplumbagin (1) was isolated along with the known tetralones trans-isoshinanolone (2) and cis-isoshinanolone (3), and the naphthoquinones plumbagin (4) and 3,3′-biplumbagin (5). Compounds 2, 4, and 5 showed cytotoxicity (IC50 520–82.1 μM) against MDA-MB-231 breast cancer cells. Moderate to low cytotoxicity was observed for the hexane, dichloromethane, and methanol extracts of the root bark (IC50 16.1, 29.7 and > 100 μg/mL, respectively), and for the methanol extract of the stem bark (IC50 59.6 μg/mL). The radical scavenging activity of the isolated constituents (1–5) was evaluated on the 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging assay. The applicability of the crude extracts and of the isolated constituents for controlling degenerative diseases is discussed.

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Bioactivity-guided isolation of mosquitocidal constituents from the rhizomes of Plumbago capensis Thunb

Cited by 23 publications

References 31 publications

Plant Extracts, Isolated Phytochemicals, and Plant-Derived Agents Which Are Lethal to Arthropod Vectors of Human Tropical Diseases - A Review

Plant Extracts, Isolated Phytochemicals, and Plant-Derived Agents Which Are Lethal to Arthropod Vectors of Human Tropical Diseases - A Review

Molecular Docking and Dynamics Simulation Studies Predict Potential Anti-ADAR2 Inhibitors: Implications for the Treatment of Cancer, Neurological, Immunological and Infectious Diseases

Phytoconstituents with Radical Scavenging and Cytotoxic Activities from Diospyros shimbaensis

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