Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea

Pozharitskaya, Olga N.; Shikov, Alexander N.; Laakso, Into; Seppänen‐Laakso, Tuulikki; Макаренко, И. Е.; Фаустова, Н.М.; Макарова, М.Н.; Makarov, Valery G.

doi:10.1016/j.jff.2015.05.030

Cited by 38 publications

(34 citation statements)

References 35 publications

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“…Strongylocentrotus droebachiensis is abundant in upper sublittoral zones at a depth of 0 – 50 m. This species is of commercial interest because it can be picked up easily by scuba divers and because its gonads are edible . This explains the numerous studies of its distribution and biochemistry . Shikov et al .…”

Section: Resultsmentioning

confidence: 99%

Diversity of Polyhydroxynaphthoquinone Pigments in North Pacific Sea Urchins

Васильева

Mishchenko

Fedoreyev

2017

Chemistry & Biodiversity

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Using high-performance liquid chromatography with diode-array detection and mass spectrometry (HPLC-DAD/MS) we investigated the composition of polyhydroxynaphthoquinone (PHNQ) pigments from sea urchins Strongylocentrotus pallidus, St. polyacanthus, St. droebachiensis, Brisaster latifrons and Echinarachnius parma, collected in the Sea of Okhotsk and the Bering Sea. Identification of PHNQ pigments from sea urchins St. polyacanthus, B. latifrons, and E. parma was performed for the first time. Among the usual PHNQ pigments, mono- and dimethoxy derivatives of spinochrome E, not previously found in other sea urchins, were discovered in St. polyacanthus and St. droebachiensis. In St. droebachiensis, two monomethoxy derivatives of echinochrome A were detected, isolated previously from only tropical sea urchins. It was found that the composition and total content of pigments of St. droebachiensis depends on the collection area of the sea urchins and its depth and varies from 88 to 331 μg/g of dry shells. Sea urchins St. pallidus, B. latifrons and E. parma had average values for PHNQ pigment content, approximately 30 μg/g, and St. polyacanthus had a low PHNQ content, 13 μg/g.

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Section: Resultsmentioning

confidence: 99%

Diversity of Polyhydroxynaphthoquinone Pigments in North Pacific Sea Urchins

Васильева

Mishchenko

Fedoreyev

2017

Chemistry & Biodiversity

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“…The proportion docosahexanoic acid (22:6n3, DHA) in BW lipids, on the contrary, was very low as has been reported also by others [ 2 , 22 ]. In our previous study, gonads of sea urchin contained about 50 μg/mg of EPA and DHA [ 4 ]. Analysis of lipid classes showed two major phospholipids—i.e., phosphatidylcholine and phosphatidylethanolamine.…”

Section: Discussionmentioning

confidence: 99%

“…EPA as well as DHA effectively inhibited COX-2 expression in LPS-stimulated HUVEC endothelial cells [ 30 ]. Recently, we have reported that lipid rich fraction from gonads of S. droebachiensis inhibited COX-2 with IC 50 = 49 μg/mL, but was not effective against COX-1 isoform [ 4 ]. It is important to note that, in our current study, body wall lipids were more effective and inhibited COX-2 in lower dose and inhibited COX-1 with IC 50 = 15.7 μg/mL.…”

Section: Discussionmentioning

confidence: 99%

“…The gonads are delicacies in many parts of the world and considered as highly valued seafood. Several studies have indicated that the gonads of S. droebachiensis are rich in important bioactive compounds like polyunsaturated fatty acids (PUFA), phospholipids, tocopherols, sterols [ 2 , 3 , 4 ], carotenoids [ 2 , 5 ], and amino acids [ 6 , 7 ]. Extract of gonad tissue has also revealed effective anti-inflammatory and antidiabetic properties [ 4 ].…”

Section: Introductionmentioning

confidence: 99%

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Chemical Profiling and Bioactivity of Body Wall Lipids from Strongylocentrotus droebachiensis

Shikov¹,

Laakso

Pozharitskaya³

et al. 2017

Marine Drugs

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The lipids from gonads and polyhydroxynaphthoquinone pigments from body walls of sea urchins are intensively studied. However, little is known about the body wall (BW) lipids. Ethanol extract (55 °C) contained about equal amounts of saturated (SaFA) and monounsaturated fatty acids (MUFA) representing 60% of total fatty acids, with myristic, palmitic and eicosenoic acids as major SaFAs and MUFAs, respectively. Non-methylene-interrupted dienes (13%) were composed of eicosadienoic and docosadienoic acids. Long-chain polyunsaturated fatty acids (LC-PUFA) included two main components, n6 arachidonic and n3 eicosapentaenoic acids, even with equal concentrations (15 μg/mg) and a balanced n6/n3 PUFA ratio (0.86). The UPLC-ELSD analysis showed that a great majority of the lipids (80%) in the ethanolic extract were phosphatidylcholine (60 μg/mg) and phosphatidylethanolamine (40 μg/mg), while the proportion of neutral lipids remained lower than 20%. In addition, alkoxyglycerol derivatives—chimyl, selachyl, and batyl alcohols—were quantified. We have assumed that the mechanism of action of body wall lipids in the present study is via the inhibition of MAPK p38, COX-1, and COX-2. Our findings open the prospective to utilize this lipid fraction as a source for the development of drugs with anti-inflammatory activity.

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“…To this end, scholars have paid more attention to the pharmacological activities and chemical constituents of sea urchin gonads. Pozharitskaya et al found that the fractions of ESD1 and ESD2 extracted from gonads of green sea urchin ( Strongylocentrotus droebachiensis ) could be the functional food supplement for the regulation of inflammation and diabetes [12]. It was shown that polysaccharides from the gonad could inhibit tumor transplant and improve immune activity [13].…”

Section: Introductionmentioning

confidence: 99%

Polysaccharide Constituents of Three Types of Sea Urchin Shells and Their Anti-Inflammatory Activities

et al. 2015

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As a source of potent anti-inflammatory traditional medicines, the quantitative chromatographic fingerprints of sea urchin shell polysaccharides were well established via pre-column derivatization high performance liquid chromatography (HPLC) analysis. Based on the quantitative results, the content of fucose and glucose could be used as preliminary distinguishing indicators among three sea urchin shell species. Besides, the anti-inflammatory activities of the polysaccharides from sea urchin shells and their gonads were also determined. The gonad polysaccharide of Anthocidaris crassispina showed the most potent anti-inflammatory activity among all samples tested.

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Bioactivity and chemical characterization of gonads of green sea urchin Strongylocentrotus droebachiensis from Barents Sea

Cited by 38 publications

References 35 publications

Diversity of Polyhydroxynaphthoquinone Pigments in North Pacific Sea Urchins

Diversity of Polyhydroxynaphthoquinone Pigments in North Pacific Sea Urchins

Chemical Profiling and Bioactivity of Body Wall Lipids from Strongylocentrotus droebachiensis

Polysaccharide Constituents of Three Types of Sea Urchin Shells and Their Anti-Inflammatory Activities

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